SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4q3k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DX6_A_GNTA602_1
(ACETYLCHOLINESTERASE)		 4q3k MGS-M1
(unidentified) 		5 / 12 GLY A  41
GLY A  42
GLY A  43
SER A 113
HIS A 201
 F  A 302 ( 4.2A)
F  A 302 (-3.9A)
F  A 302 (-3.4A)
F  A 302 (-2.5A)
None
 0.25A 1dx6A-4q3kA:
18.4		 1dx6A-4q3kA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DX6_A_GNTA602_1
(ACETYLCHOLINESTERASE)		 4q3k MGS-M1
(unidentified) 		5 / 12 GLY A  41
GLY A  42
GLY A  43
SER A 113
TRP A 147
 F  A 302 ( 4.2A)
F  A 302 (-3.9A)
F  A 302 (-3.4A)
F  A 302 (-2.5A)
PGE  A 303 ( 4.6A)
 0.76A 1dx6A-4q3kA:
18.4		 1dx6A-4q3kA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4q3k MGS-M1
(unidentified) 		5 / 12 ALA A  56
LEU A  60
PHE A  67
LEU A  37
ILE A  38
 None
 0.99A 1g5yB-4q3kA:
undetectable		 1g5yB-4q3kA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QTI_A_GNTA600_1
(ACETYLCHOLINESTERASE)		 4q3k MGS-M1
(unidentified) 		5 / 12 GLY A  41
GLY A  42
GLY A  43
SER A 113
HIS A 201
 F  A 302 ( 4.2A)
F  A 302 (-3.9A)
F  A 302 (-3.4A)
F  A 302 (-2.5A)
None
 0.25A 1qtiA-4q3kA:
17.6		 1qtiA-4q3kA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_2
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 4q3k MGS-M1
(unidentified) 		4 / 7 VAL A 128
VAL A 109
TYR A  19
CYH A  18
 None
 1.03A 1t46A-4q3kA:
undetectable		 1t46A-4q3kA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W6R_A_GNTA1536_1
(ACETYLCHOLINESTERASE)		 4q3k MGS-M1
(unidentified) 		5 / 12 GLY A  41
GLY A  42
GLY A  43
SER A 113
HIS A 201
 F  A 302 ( 4.2A)
F  A 302 (-3.9A)
F  A 302 (-3.4A)
F  A 302 (-2.5A)
None
 0.26A 1w6rA-4q3kA:
18.3		 1w6rA-4q3kA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACE_A_ACHA998_0
(ACETYLCHOLINESTERASE)		 4q3k MGS-M1
(unidentified) 		5 / 9 GLY A  41
GLY A  42
SER A 113
ALA A 114
HIS A 201
 F  A 302 ( 4.2A)
F  A 302 (-3.9A)
F  A 302 (-2.5A)
F  A 302 (-3.6A)
None
 0.90A 2aceA-4q3kA:
4.3		 2aceA-4q3kA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACE_A_ACHA998_0
(ACETYLCHOLINESTERASE)		 4q3k MGS-M1
(unidentified) 		5 / 9 GLY A  42
GLY A  43
SER A 113
ALA A 114
HIS A 201
 F  A 302 (-3.9A)
F  A 302 (-3.4A)
F  A 302 (-2.5A)
F  A 302 (-3.6A)
None
 0.40A 2aceA-4q3kA:
4.3		 2aceA-4q3kA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_A_ACTA544_0
(ACETYLCHOLINESTERASE)		 4q3k MGS-M1
(unidentified) 		4 / 8 GLY A  42
GLY A  43
ALA A 114
HIS A 201
 F  A 302 (-3.9A)
F  A 302 (-3.4A)
F  A 302 (-3.6A)
None
 0.31A 2ha4A-4q3kA:
17.3		 2ha4A-4q3kA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACTB601_0
(ACETYLCHOLINESTERASE)		 4q3k MGS-M1
(unidentified) 		4 / 7 GLY A  42
GLY A  43
ALA A 114
HIS A 201
 F  A 302 (-3.9A)
F  A 302 (-3.4A)
F  A 302 (-3.6A)
None
 0.25A 2ha4B-4q3kA:
18.2		 2ha4B-4q3kA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_1
(ESTROGEN RECEPTOR)		 4q3k MGS-M1
(unidentified) 		5 / 12 ALA A  89
LEU A  90
LEU A  37
GLY A 115
LEU A 118
 None
 1.00A 2jfaB-4q3kA:
undetectable		 2jfaB-4q3kA:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OMB_A_IPHA2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 4q3k MGS-M1
(unidentified) 		4 / 5 HIS A 117
PRO A 150
TYR A  44
PRO A  82
 None
 1.10A 2ombA-4q3kA:
undetectable
2ombB-4q3kA:
undetectable		 2ombA-4q3kA:
22.78
2ombB-4q3kA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_B_CTCB1385_0
(TETX2 PROTEIN)		 4q3k MGS-M1
(unidentified) 		4 / 8 PHE A  39
GLY A 111
PRO A 130
GLY A 126
 None
 0.95A 2y6rB-4q3kA:
undetectable		 2y6rB-4q3kA:
26.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM9_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4q3k MGS-M1
(unidentified) 		4 / 8 ALA A 114
TYR A  71
HIS A 117
GLY A  43
 F  A 302 (-3.6A)
None
None
F  A 302 (-3.4A)
 0.88A 2zm9A-4q3kA:
undetectable		 2zm9A-4q3kA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_A_BEZA999_0
(CHOLINESTERASE)		 4q3k MGS-M1
(unidentified) 		4 / 7 GLY A  42
GLY A  43
SER A 113
HIS A 201
 F  A 302 (-3.9A)
F  A 302 (-3.4A)
F  A 302 (-2.5A)
None
 0.42A 3o9mA-4q3kA:
18.6		 3o9mA-4q3kA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_B_BEZB999_0
(CHOLINESTERASE)		 4q3k MGS-M1
(unidentified) 		4 / 6 GLY A  42
GLY A  43
SER A 113
HIS A 201
 F  A 302 (-3.9A)
F  A 302 (-3.4A)
F  A 302 (-2.5A)
None
 0.49A 3o9mB-4q3kA:
18.7		 3o9mB-4q3kA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_A_GNTA604_1
(ACETYLCHOLINESTERASE)		 4q3k MGS-M1
(unidentified) 		5 / 12 GLY A  41
GLY A  42
GLY A  43
SER A 113
HIS A 201
 F  A 302 ( 4.2A)
F  A 302 (-3.9A)
F  A 302 (-3.4A)
F  A 302 (-2.5A)
None
 0.22A 4ey6A-4q3kA:
18.3		 4ey6A-4q3kA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_B_GNTB605_1
(ACETYLCHOLINESTERASE)		 4q3k MGS-M1
(unidentified) 		5 / 12 GLY A  41
GLY A  42
GLY A  43
SER A 113
HIS A 201
 F  A 302 ( 4.2A)
F  A 302 (-3.9A)
F  A 302 (-3.4A)
F  A 302 (-2.5A)
None
 0.24A 4ey6B-4q3kA:
17.4		 4ey6B-4q3kA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4q3k MGS-M1
(unidentified) 		4 / 8 LEU A 118
ARG A  81
VAL A  12
GLY A  13
 None
 0.83A 4klrB-4q3kA:
3.8		 4klrB-4q3kA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA603_1
(SERUM ALBUMIN)		 4q3k MGS-M1
(unidentified) 		5 / 10 LEU A 233
ASN A 131
LEU A  90
LEU A 122
VAL A 128
 None
 1.20A 4po0A-4q3kA:
undetectable		 4po0A-4q3kA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QKN_A_JMSA602_1
(ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO)		 4q3k MGS-M1
(unidentified) 		4 / 8 LEU A 195
PRO A 177
VAL A 172
HIS A 201
 None
None
PGE  A 303 ( 4.6A)
None
 1.13A 4qknA-4q3kA:
undetectable		 4qknA-4q3kA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 4q3k MGS-M1
(unidentified) 		4 / 6 TYR A 137
GLY A  41
GLU A  51
ASP A  49
 None
F  A 302 ( 4.2A)
None
None
 1.26A 5emlA-4q3kA:
2.3		 5emlA-4q3kA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_1
(ESTROGEN RECEPTOR)		 4q3k MGS-M1
(unidentified) 		5 / 12 THR A 120
LEU A 122
ALA A 123
LEU A  37
LEU A 135
 None
 1.16A 5gs4A-4q3kA:
undetectable		 5gs4A-4q3kA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_1
(CYTOCHROME P450 3A4)		 4q3k MGS-M1
(unidentified) 		5 / 12 ILE A 110
ALA A 123
THR A 158
ILE A 189
GLU A 192
 None
 1.07A 5vceA-4q3kA:
undetectable		 5vceA-4q3kA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA410_0
(UNCHARACTERIZED
PROTEIN KDOO)		 4q3k MGS-M1
(unidentified) 		4 / 4 GLY A 206
LEU A 203
VAL A 222
GLU A 219
 None
 1.42A 5yw0A-4q3kA:
undetectable		 5yw0A-4q3kA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		 4q3k MGS-M1
(unidentified) 		4 / 8 GLY A  43
GLN A  45
SER A 113
TRP A 147
 F  A 302 (-3.4A)
None
F  A 302 (-2.5A)
PGE  A 303 ( 4.6A)
 0.97A 6eqpA-4q3kA:
18.6		 6eqpA-4q3kA:
17.18