SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4q3l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_A_ADNA601_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 4q3l MGS-M2
(unidentified) 		4 / 5 THR A 194
THR A 224
HIS A 249
HIS A 200
 None
 1.40A 1d4fA-4q3lA:
5.7		 1d4fA-4q3lA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_D_ADND604_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 4q3l MGS-M2
(unidentified) 		4 / 5 THR A 194
THR A 224
HIS A 249
HIS A 200
 None
 1.34A 1d4fD-4q3lA:
5.0		 1d4fD-4q3lA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_A_IPBA600_0
(ODORANT-BINDING
PROTEIN)		 4q3l MGS-M2
(unidentified) 		4 / 6 VAL A 119
MET A 117
VAL A 202
ILE A 102
 None
 0.98A 1e06A-4q3lA:
undetectable		 1e06A-4q3lA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KVL_A_CLSA371_1
(BETA-LACTAMASE)		 4q3l MGS-M2
(unidentified) 		5 / 10 LEU A  78
GLN A  75
TYR A  55
TYR A  98
THR A  36
 None
 1.42A 1kvlA-4q3lA:
undetectable		 1kvlA-4q3lA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_F_BEZF5023_0
(CES1 PROTEIN)		 4q3l MGS-M2
(unidentified) 		4 / 6 GLY A  31
SER A  97
ILE A 157
HIS A 249
 None
 0.97A 1yajF-4q3lA:
12.9		 1yajF-4q3lA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_J_BEZJ5041_0
(CES1 PROTEIN)		 4q3l MGS-M2
(unidentified) 		4 / 4 GLY A  31
SER A  97
ILE A 157
HIS A 249
 None
 0.92A 1yajJ-4q3lA:
5.7		 1yajJ-4q3lA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC2_0
(N8-ACTINOMYCIN D)		 4q3l MGS-M2
(unidentified) 		3 / 3 THR A 258
PRO A 256
THR A 260
 None
 0.69A 209dC-4q3lA:
undetectable		 209dC-4q3lA:
2.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4q3l MGS-M2
(unidentified) 		5 / 9 LEU A  78
PHE A 106
LEU A  29
ILE A 102
TYR A  55
 None
 0.85A 2f78A-4q3lA:
undetectable		 2f78A-4q3lA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4q3l MGS-M2
(unidentified) 		5 / 9 LEU A  78
PHE A 106
LEU A  29
ILE A 102
TYR A  55
 None
 0.83A 2f78B-4q3lA:
undetectable		 2f78B-4q3lA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4q3l MGS-M2
(unidentified) 		5 / 9 LEU A  78
PHE A 106
LEU A  29
ILE A 102
TYR A  55
 None
 0.90A 2f7aA-4q3lA:
undetectable		 2f7aA-4q3lA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4q3l MGS-M2
(unidentified) 		5 / 9 LEU A  78
PHE A 106
LEU A  29
ILE A 102
TYR A  55
 None
 0.88A 2f7aB-4q3lA:
undetectable		 2f7aB-4q3lA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4q3l MGS-M2
(unidentified) 		5 / 10 LEU A  78
PHE A 106
LEU A  29
ILE A 102
TYR A  55
 None
 0.92A 2f8dA-4q3lA:
undetectable		 2f8dA-4q3lA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_B_BEZB1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4q3l MGS-M2
(unidentified) 		5 / 10 LEU A  78
PHE A 106
LEU A  29
ILE A 102
TYR A  55
 None
 0.90A 2f8dB-4q3lA:
undetectable		 2f8dB-4q3lA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PH9_A_GNTA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4q3l MGS-M2
(unidentified) 		4 / 7 GLN A  72
TYR A  70
TYR A  55
ILE A  11
 None
 1.35A 2ph9A-4q3lA:
undetectable
2ph9B-4q3lA:
undetectable		 2ph9A-4q3lA:
20.63
2ph9B-4q3lA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_C_ADNC438_2
(ADENOSYLHOMOCYSTEINA
SE)		 4q3l MGS-M2
(unidentified) 		4 / 5 THR A 194
THR A 224
HIS A 249
HIS A 200
 None
 1.42A 3g1uC-4q3lA:
5.5		 3g1uC-4q3lA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4q3l MGS-M2
(unidentified) 		4 / 6 VAL A 119
ILE A 209
ILE A 215
LEU A 214
 None
 0.76A 3hegA-4q3lA:
undetectable		 3hegA-4q3lA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PQZ_L_CCSL11_0
(GROWTH FACTOR
RECEPTOR-BOUND
PROTEIN 7
CYCLIC PEPTIDE)		 4q3l MGS-M2
(unidentified) 		4 / 4 LEU A 223
TRP A 129
PHE A 227
PRO A 226
 None
 1.20A 3pqzD-4q3lA:
0.0
3pqzL-4q3lA:
undetectable		 3pqzD-4q3lA:
16.55
3pqzL-4q3lA:
3.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PQZ_M_CCSM11_0
(GROWTH FACTOR
RECEPTOR-BOUND
PROTEIN 7
CYCLIC PEPTIDE)		 4q3l MGS-M2
(unidentified) 		4 / 4 LEU A 223
TRP A 129
PHE A 227
PRO A 226
 None
 1.19A 3pqzC-4q3lA:
0.4
3pqzM-4q3lA:
undetectable		 3pqzC-4q3lA:
16.55
3pqzM-4q3lA:
3.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_B_BEZB264_0
(ECHA1_1)		 4q3l MGS-M2
(unidentified) 		4 / 7 LEU A 206
ALA A 107
ALA A 108
MET A 117
 None
 0.62A 3r9tB-4q3lA:
undetectable		 3r9tB-4q3lA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 4q3l MGS-M2
(unidentified) 		4 / 8 LEU A  86
VAL A  27
VAL A  51
LEU A  82
 None
 0.91A 3v81C-4q3lA:
undetectable		 3v81C-4q3lA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEL_A_ACRA1001_2
(ALPHA-GLUCOSIDASE)		 4q3l MGS-M2
(unidentified) 		4 / 6 ILE A 154
ILE A  28
TRP A  39
MET A  34
 None
 1.39A 3welA-4q3lA:
undetectable		 3welA-4q3lA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4q3l MGS-M2
(unidentified) 		4 / 6 LEU A 180
ARG A 173
VAL A 140
ALA A 141
 None
 1.00A 4nkxA-4q3lA:
undetectable		 4nkxA-4q3lA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4q3l MGS-M2
(unidentified) 		4 / 6 ILE A  96
GLY A  99
ILE A 114
ILE A  28
 None
 0.63A 4o8fB-4q3lA:
undetectable		 4o8fB-4q3lA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_2
(HISTONE DEACETYLASE
8)		 4q3l MGS-M2
(unidentified) 		3 / 3 PRO A 111
MET A 113
TYR A 110
 None
 0.98A 4qa2B-4q3lA:
undetectable		 4qa2B-4q3lA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 4q3l MGS-M2
(unidentified) 		4 / 5 GLN A 105
LEU A 104
SER A 101
ASP A 132
 None
 1.21A 4qtuD-4q3lA:
undetectable		 4qtuD-4q3lA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_A_ECLA1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 4q3l MGS-M2
(unidentified) 		4 / 7 ILE A 102
LEU A  79
ILE A 209
ALA A  91
 None
 0.84A 6b5vA-4q3lA:
undetectable
6b5vC-4q3lA:
undetectable		 6b5vA-4q3lA:
12.76
6b5vC-4q3lA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_C_ECLC1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 4q3l MGS-M2
(unidentified) 		4 / 7 ILE A 102
LEU A  79
ILE A 209
ALA A  91
 None
 0.84A 6b5vC-4q3lA:
undetectable
6b5vD-4q3lA:
undetectable		 6b5vC-4q3lA:
12.76
6b5vD-4q3lA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_D_ECLD1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 4q3l MGS-M2
(unidentified) 		4 / 7 ALA A  91
ILE A 102
LEU A  79
ILE A 209
 None
 0.85A 6b5vB-4q3lA:
undetectable
6b5vD-4q3lA:
undetectable		 6b5vB-4q3lA:
12.76
6b5vD-4q3lA:
12.76