SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4q3n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CET_A_CLQA1001_0
(PROTEIN (L-LACTATE
DEHYDROGENASE))		 4q3n MGS-M5
(unidentified) 		6 / 9 VAL A   9
GLY A  10
ASP A  35
ILE A  36
ALA A  79
ILE A  99
 None
CL  A 402 ( 4.1A)
None
None
None
None
 0.70A 1cetA-4q3nA:
41.7		 1cetA-4q3nA:
32.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CET_A_CLQA1001_0
(PROTEIN (L-LACTATE
DEHYDROGENASE))		 4q3n MGS-M5
(unidentified) 		6 / 9 VAL A   9
GLY A  10
ASP A  35
ILE A  36
TYR A  66
ALA A  79
 None
CL  A 402 ( 4.1A)
None
None
GOL  A 415 (-4.5A)
None
 0.78A 1cetA-4q3nA:
41.7		 1cetA-4q3nA:
32.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_A_SAMA1401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 4q3n MGS-M5
(unidentified) 		5 / 11 LEU A  33
GLY A  12
GLY A  10
TYR A  20
LEU A  52
 None
CL  A 402 ( 4.1A)
CL  A 402 ( 4.1A)
None
None
 1.02A 1p91A-4q3nA:
2.3		 1p91A-4q3nA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_E_NCAE507_0
(NAD-DEPENDENT
DEACETYLASE 2)		 4q3n MGS-M5
(unidentified) 		4 / 7 ILE A 285
LEU A 288
ASN A 259
ILE A 271
 None
 0.85A 1yc2E-4q3nA:
4.6		 1yc2E-4q3nA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_C_SAMC226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4q3n MGS-M5
(unidentified) 		5 / 12 ASP A  35
VAL A   8
GLY A  43
LEU A  48
ILE A  61
 None
 0.86A 3ku1C-4q3nA:
5.7		 3ku1C-4q3nA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_B_CL6B506_1
(CHOLESTEROL
24-HYDROXYLASE)		 4q3n MGS-M5
(unidentified) 		5 / 12 VAL A  14
LEU A  74
THR A  78
ALA A 119
ALA A 237
 None
 0.99A 3mdvB-4q3nA:
undetectable		 3mdvB-4q3nA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_2
(FIV PROTEASE)		 4q3n MGS-M5
(unidentified) 		5 / 10 LEU A 305
ASP A 124
ILE A 142
VAL A 257
ILE A 172
 None
 0.89A 3ogpB-4q3nA:
undetectable		 3ogpB-4q3nA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGQ_A_AB1A200_1
(FIV PROTEASE)		 4q3n MGS-M5
(unidentified) 		5 / 10 LEU A 305
ASP A 124
ILE A 142
VAL A 257
ILE A 172
 None
 0.94A 3ogqA-4q3nA:
undetectable		 3ogqA-4q3nA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4q3n MGS-M5
(unidentified) 		5 / 12 ALA A  72
PHE A 112
ILE A  77
LEU A 116
THR A 242
 None
 1.06A 3rukA-4q3nA:
undetectable		 3rukA-4q3nA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ1_X_DXCX75_0
(CYTOCHROME C7)		 4q3n MGS-M5
(unidentified) 		4 / 6 ILE A  77
LEU A 116
PHE A 112
GLY A  73
 None
None
None
GOL  A 413 ( 4.2A)
 0.93A 3sj1X-4q3nA:
undetectable		 3sj1X-4q3nA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		 4q3n MGS-M5
(unidentified) 		5 / 9 LEU A 173
LEU A 288
ILE A 194
ILE A 157
VAL A 182
 None
 1.28A 3tmzA-4q3nA:
undetectable		 3tmzA-4q3nA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HBF_A_DXCA75_0
(PPCA)		 4q3n MGS-M5
(unidentified) 		4 / 7 ILE A  77
LEU A 116
PHE A 112
GLY A  73
 None
None
None
GOL  A 413 ( 4.2A)
 1.01A 4hbfA-4q3nA:
undetectable		 4hbfA-4q3nA:
14.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OKN_B_KANB403_1
(L-LACTATE
DEHYDROGENASE A
CHAIN)		 4q3n MGS-M5
(unidentified) 		5 / 9 ASP A  35
TYR A  66
ALA A  79
ARG A  95
ILE A  99
 None
GOL  A 415 (-4.5A)
None
None
None
 0.83A 4oknB-4q3nA:
42.5		 4oknB-4q3nA:
35.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_3_BEZ3801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 4q3n MGS-M5
(unidentified) 		4 / 4 LEU A 117
ILE A  77
GLY A 143
ILE A 100
 None
 0.80A 5dzk3-4q3nA:
undetectable
5dzkm-4q3nA:
undetectable		 5dzk3-4q3nA:
5.88
5dzkm-4q3nA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_W_BEZW801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4q3n MGS-M5
(unidentified) 		4 / 5 ILE A  77
GLY A 143
ILE A 100
LEU A 117
 None
 0.74A 5dzkB-4q3nA:
undetectable
5dzkI-4q3nA:
undetectable
5dzkW-4q3nA:
undetectable		 5dzkB-4q3nA:
22.63
5dzkI-4q3nA:
21.91
5dzkW-4q3nA:
5.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Z_BEZZ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 4q3n MGS-M5
(unidentified) 		4 / 4 ILE A  77
GLY A 143
ILE A 100
LEU A 117
 None
 0.76A 5dzkl-4q3nA:
undetectable
5dzkz-4q3nA:
undetectable		 5dzkl-4q3nA:
21.91
5dzkz-4q3nA:
5.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 4q3n MGS-M5
(unidentified) 		4 / 6 TYR A 232
GLY A  12
GLU A  44
ASP A  37
 None
CL  A 402 ( 4.1A)
None
None
 1.33A 5emlA-4q3nA:
undetectable		 5emlA-4q3nA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 4q3n MGS-M5
(unidentified) 		3 / 3 LYS A 215
ASP A 218
ARG A 152
 None
ACT  A 408 (-3.7A)
ACT  A 409 ( 4.8A)
 0.97A 5jwaA-4q3nA:
4.5
5jwaH-4q3nA:
5.1		 5jwaA-4q3nA:
18.60
5jwaH-4q3nA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MLM_A_STRA401_1
(-)		 4q3n MGS-M5
(unidentified) 		5 / 12 PHE A 112
ALA A 119
SER A 144
VAL A  76
ILE A  77
 None
 1.40A 5mlmA-4q3nA:
9.6		 5mlmA-4q3nA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1802_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4q3n MGS-M5
(unidentified) 		4 / 7 SER A 120
THR A  78
VAL A   8
ILE A  36
 None
 1.17A 5vkqA-4q3nA:
undetectable
5vkqB-4q3nA:
undetectable		 5vkqA-4q3nA:
10.73
5vkqB-4q3nA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4q3n MGS-M5
(unidentified) 		4 / 8 SER A 120
THR A  78
VAL A   8
ILE A  36
 None
 1.15A 5vkqB-4q3nA:
undetectable
5vkqC-4q3nA:
undetectable		 5vkqB-4q3nA:
10.73
5vkqC-4q3nA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4q3n MGS-M5
(unidentified) 		4 / 7 SER A 120
THR A  78
VAL A   8
ILE A  36
 None
 1.15A 5vkqC-4q3nA:
undetectable
5vkqD-4q3nA:
undetectable		 5vkqC-4q3nA:
10.73
5vkqD-4q3nA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_C_CHDC401_0
(BILE SALT HYDROLASE)		 4q3n MGS-M5
(unidentified) 		4 / 8 ILE A 285
ASN A 299
LEU A 305
ALA A 302
 None
 0.76A 5y7pC-4q3nA:
undetectable		 5y7pC-4q3nA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GSD_A_STRA401_0
(PROGESTERONE
5-BETA-REDUCTASE)		 4q3n MGS-M5
(unidentified) 		5 / 12 VAL A 104
PHE A 112
ILE A 107
SER A 120
VAL A  76
 None
 1.38A 6gsdA-4q3nA:
9.4		 6gsdA-4q3nA:
14.98