SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4q3o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA442_1
(ALPHA AMYLASE)		 4q3o MGS-MT1
(unidentified) 		5 / 11 GLY A 221
PHE A 292
GLY A 198
GLY A 126
GLY A 127
 None
None
None
CL  A 401 ( 4.4A)
CL  A 401 (-3.5A)
 1.06A 1mxgA-4q3oA:
undetectable		 1mxgA-4q3oA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACE_A_ACHA998_0
(ACETYLCHOLINESTERASE)		 4q3o MGS-MT1
(unidentified) 		5 / 9 GLY A 126
GLY A 127
SER A 194
ALA A 195
HIS A 320
 CL  A 401 ( 4.4A)
CL  A 401 (-3.5A)
CL  A 401 (-2.5A)
CL  A 401 ( 4.8A)
None
 0.94A 2aceA-4q3oA:
4.4		 2aceA-4q3oA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RIW_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 4q3o MGS-MT1
(unidentified) 		5 / 10 ALA A 195
LEU A 264
LEU A 269
LEU A 227
ARG A 256
 CL  A 401 ( 4.8A)
None
None
None
None
 0.98A 2riwA-4q3oA:
undetectable
2riwB-4q3oA:
undetectable		 2riwA-4q3oA:
21.39
2riwB-4q3oA:
8.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4q3o MGS-MT1
(unidentified) 		4 / 7 TYR A  71
GLY A 252
ALA A 253
LEU A 257
 None
 0.83A 2wekB-4q3oA:
2.6		 2wekB-4q3oA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 4q3o MGS-MT1
(unidentified) 		5 / 12 ILE A  38
GLY A 287
THR A 288
GLY A 317
THR A 193
 None
 0.74A 2y7hB-4q3oA:
undetectable		 2y7hB-4q3oA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 4q3o MGS-MT1
(unidentified) 		5 / 12 ILE A  38
GLY A 287
THR A 288
GLY A 317
THR A 193
 None
 0.74A 2y7hC-4q3oA:
undetectable		 2y7hC-4q3oA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
316D_C_DVAC2_0
(8-FLUORO-ACTINOMYCIN
D)		 4q3o MGS-MT1
(unidentified) 		3 / 3 THR A 282
PRO A 281
THR A 309
 None
 0.91A 316dC-4q3oA:
undetectable		 316dC-4q3oA:
3.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB500_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4q3o MGS-MT1
(unidentified) 		4 / 7 THR A  93
GLU A  95
THR A 108
VAL A 151
 None
 0.53A 3em0B-4q3oA:
undetectable		 3em0B-4q3oA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6W_A_SAMA465_0
(RRNA METHYLASE)		 4q3o MGS-MT1
(unidentified) 		5 / 12 GLY A 196
GLY A 197
VAL A 104
VAL A 178
LEU A 179
 None
 1.07A 3m6wA-4q3oA:
undetectable		 3m6wA-4q3oA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_A_BEZA999_0
(CHOLINESTERASE)		 4q3o MGS-MT1
(unidentified) 		6 / 7 GLY A 126
GLY A 127
SER A 194
LEU A 251
PHE A 292
HIS A 320
 CL  A 401 ( 4.4A)
CL  A 401 (-3.5A)
CL  A 401 (-2.5A)
None
None
None
 1.34A 3o9mA-4q3oA:
2.3		 3o9mA-4q3oA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_A_BEZA999_0
(CHOLINESTERASE)		 4q3o MGS-MT1
(unidentified) 		5 / 7 GLY A 127
SER A 194
LEU A 251
PHE A 292
HIS A 320
 CL  A 401 (-3.5A)
CL  A 401 (-2.5A)
None
None
None
 0.86A 3o9mA-4q3oA:
2.3		 3o9mA-4q3oA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_B_BEZB999_0
(CHOLINESTERASE)		 4q3o MGS-MT1
(unidentified) 		5 / 6 GLY A 126
GLY A 127
SER A 194
LEU A 251
HIS A 320
 CL  A 401 ( 4.4A)
CL  A 401 (-3.5A)
CL  A 401 (-2.5A)
None
None
 1.39A 3o9mB-4q3oA:
16.4		 3o9mB-4q3oA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_1
(N-METHYLTRANSFERASE)		 4q3o MGS-MT1
(unidentified) 		3 / 3 TYR A 323
TYR A 219
GLU A 139
 None
 0.55A 3pfgA-4q3oA:
2.8		 3pfgA-4q3oA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4q3o MGS-MT1
(unidentified) 		4 / 5 TYR A 219
SER A 194
ASP A 123
ILE A 138
 None
CL  A 401 (-2.5A)
None
None
 1.29A 3uj7B-4q3oA:
4.1		 3uj7B-4q3oA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4q3o MGS-MT1
(unidentified) 		4 / 5 TYR A 219
SER A 194
ASP A 123
ILE A 142
 None
CL  A 401 (-2.5A)
None
None
 1.07A 3uj7B-4q3oA:
4.1		 3uj7B-4q3oA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4q3o MGS-MT1
(unidentified) 		4 / 8 TYR A 157
VAL A 155
MET A 190
ILE A 122
 None
 1.06A 4a97D-4q3oA:
undetectable		 4a97D-4q3oA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_F_BEZF501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 4q3o MGS-MT1
(unidentified) 		4 / 8 ALA A 255
SER A 254
LEU A 251
ARG A 256
 None
 1.07A 4ijiF-4q3oA:
undetectable		 4ijiF-4q3oA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4q3o MGS-MT1
(unidentified) 		4 / 5 ASP A 170
LYS A 173
HIS A 174
ARG A 177
 None
 1.14A 5a06B-4q3oA:
3.6		 5a06B-4q3oA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1344_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4q3o MGS-MT1
(unidentified) 		4 / 5 ASP A 170
LYS A 173
HIS A 174
ARG A 177
 None
 1.14A 5a06F-4q3oA:
3.0		 5a06F-4q3oA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_A_SAMA301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4q3o MGS-MT1
(unidentified) 		5 / 12 ASP A 241
ASP A 226
PHE A 292
GLY A 231
TYR A 235
 None
 1.23A 5hfjA-4q3oA:
undetectable		 5hfjA-4q3oA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_H_SAMH301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4q3o MGS-MT1
(unidentified) 		5 / 12 ASP A 241
ASP A 226
PHE A 292
GLY A 231
TYR A 235
 None
 1.33A 5hfjH-4q3oA:
undetectable		 5hfjH-4q3oA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_2
(PROTEASE E35D-SQV)		 4q3o MGS-MT1
(unidentified) 		5 / 9 VAL A  94
ILE A 138
GLY A 141
ILE A 144
PRO A 109
 GOL  A 405 (-4.4A)
None
None
None
None
 1.09A 5kqxB-4q3oA:
undetectable		 5kqxB-4q3oA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCN_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4q3o MGS-MT1
(unidentified) 		5 / 12 ILE A 124
GLY A 197
TYR A 336
LEU A 339
ILE A 218
 None
 0.80A 5ycnA-4q3oA:
undetectable		 5ycnA-4q3oA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_E_PCFE202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4q3o MGS-MT1
(unidentified) 		4 / 8 GLN A 333
TYR A  90
ILE A 142
VAL A 325
 GOL  A 406 (-4.7A)
GOL  A 406 (-4.7A)
None
None
 0.76A 6hu9a-4q3oA:
undetectable
6hu9e-4q3oA:
undetectable		 6hu9a-4q3oA:
21.85
6hu9e-4q3oA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IFT_A_SAMA301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A)		 4q3o MGS-MT1
(unidentified) 		5 / 12 ILE A 124
GLY A 192
GLY A 221
ALA A 321
ILE A 218
 None
 1.02A 6iftA-4q3oA:
3.2		 6iftA-4q3oA:
21.67