SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4q3r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		 4q3r ARGINASE
(Schistosoma
mansoni) 		3 / 3 ASP A  65
PHE A  52
VAL A 125
 None
 0.79A 1kijB-4q3rA:
undetectable		 1kijB-4q3rA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQW_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN)		 4q3r ARGINASE
(Schistosoma
mansoni) 		5 / 12 ILE A 238
THR A 274
LEU A 282
LEU A 305
ILE A 328
 None
 1.30A 1kqwA-4q3rA:
undetectable		 1kqwA-4q3rA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_2
(PROTEASE)		 4q3r ARGINASE
(Schistosoma
mansoni) 		4 / 6 ASP A 267
GLY A 287
ILE A 290
ILE A 263
 None
 0.90A 1n49D-4q3rA:
undetectable		 1n49D-4q3rA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N6C_A_SAMA402_0
(SET
DOMAIN-CONTAINING
PROTEIN 7)		 4q3r ARGINASE
(Schistosoma
mansoni) 		5 / 11 ILE A 138
GLY A 140
GLU A 143
ASN A 110
GLU A 304
 None
 1.31A 1n6cA-4q3rA:
undetectable		 1n6cA-4q3rA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4q3r ARGINASE
(Schistosoma
mansoni) 		4 / 8 HIS A 156
ASP A 158
THR A  31
ASP A 262
 MN  A 402 ( 3.3A)
MN  A 401 ( 2.5A)
None
MN  A 402 (-2.8A)
 0.98A 1p7lC-4q3rA:
undetectable		 1p7lC-4q3rA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4q3r ARGINASE
(Schistosoma
mansoni) 		4 / 8 HIS A 156
ASP A 158
THR A  31
ASP A 262
 MN  A 402 ( 3.3A)
MN  A 401 ( 2.5A)
None
MN  A 402 (-2.8A)
 0.98A 1p7lD-4q3rA:
undetectable		 1p7lD-4q3rA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4q3r ARGINASE
(Schistosoma
mansoni) 		5 / 10 PHE A  26
LEU A 333
VAL A  56
PHE A  52
VAL A 125
 None
 1.49A 1q23E-4q3rA:
undetectable		 1q23E-4q3rA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4q3r ARGINASE
(Schistosoma
mansoni) 		5 / 10 PHE A  26
LEU A 333
VAL A  56
PHE A  52
VAL A 125
 None
 1.44A 1q23K-4q3rA:
undetectable		 1q23K-4q3rA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4q3r ARGINASE
(Schistosoma
mansoni) 		4 / 8 HIS A 156
ASP A 158
THR A  31
ASP A 262
 MN  A 402 ( 3.3A)
MN  A 401 ( 2.5A)
None
MN  A 402 (-2.8A)
 0.99A 1rg9A-4q3rA:
undetectable		 1rg9A-4q3rA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4q3r ARGINASE
(Schistosoma
mansoni) 		4 / 8 HIS A 156
ASP A 158
THR A  31
ASP A 262
 MN  A 402 ( 3.3A)
MN  A 401 ( 2.5A)
None
MN  A 402 (-2.8A)
 1.00A 1rg9C-4q3rA:
undetectable		 1rg9C-4q3rA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4q3r ARGINASE
(Schistosoma
mansoni) 		4 / 8 HIS A 156
ASP A 158
THR A  31
ASP A 262
 MN  A 402 ( 3.3A)
MN  A 401 ( 2.5A)
None
MN  A 402 (-2.8A)
 1.00A 1rg9D-4q3rA:
undetectable		 1rg9D-4q3rA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4q3r ARGINASE
(Schistosoma
mansoni) 		5 / 12 HIS A 156
ASP A 264
THR A 274
GLY A 172
HIS A 171
 MN  A 402 ( 3.3A)
MN  A 402 ( 2.1A)
None
XA2  A 407 ( 3.8A)
XA2  A 407 (-3.2A)
 1.37A 1v8bA-4q3rA:
2.5		 1v8bA-4q3rA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_B_ADNB1502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4q3r ARGINASE
(Schistosoma
mansoni) 		5 / 12 HIS A 156
ASP A 264
THR A 274
GLY A 172
HIS A 171
 MN  A 402 ( 3.3A)
MN  A 402 ( 2.1A)
None
XA2  A 407 ( 3.8A)
XA2  A 407 (-3.2A)
 1.37A 1v8bB-4q3rA:
2.3		 1v8bB-4q3rA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_D_ADND3502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4q3r ARGINASE
(Schistosoma
mansoni) 		5 / 12 HIS A 156
ASP A 264
THR A 274
GLY A 172
HIS A 171
 MN  A 402 ( 3.3A)
MN  A 402 ( 2.1A)
None
XA2  A 407 ( 3.8A)
XA2  A 407 (-3.2A)
 1.36A 1v8bD-4q3rA:
undetectable		 1v8bD-4q3rA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A15_A_NCAA1001_0
(HYPOTHETICAL PROTEIN
RV0760C)		 4q3r ARGINASE
(Schistosoma
mansoni) 		5 / 11 SER A 260
VAL A 150
ILE A 204
LEU A 199
LEU A 178
 None
 1.15A 2a15A-4q3rA:
undetectable		 2a15A-4q3rA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 4q3r ARGINASE
(Schistosoma
mansoni) 		4 / 5 LEU A  63
PRO A 123
ALA A  24
ILE A  61
 None
 1.02A 2aofB-4q3rA:
undetectable		 2aofB-4q3rA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		 4q3r ARGINASE
(Schistosoma
mansoni) 		4 / 8 SER A 167
SER A 165
ASN A 160
LYS A  86
 XA2  A 407 (-2.7A)
XA2  A 407 ( 4.4A)
XA2  A 407 (-4.2A)
None
 1.10A 2cmlD-4q3rA:
undetectable		 2cmlD-4q3rA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_B_BEZB1352_0
(D-AMINO-ACID OXIDASE)		 4q3r ARGINASE
(Schistosoma
mansoni) 		4 / 6 LEU A 209
TYR A 206
ILE A 220
GLY A 172
 None
None
None
XA2  A 407 ( 3.8A)
 0.89A 2du8B-4q3rA:
2.4		 2du8B-4q3rA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA801_1
(TRANSPORTER)		 4q3r ARGINASE
(Schistosoma
mansoni) 		5 / 11 LEU A 288
LEU A 284
ILE A 328
ALA A 271
LEU A 305
 None
 1.10A 2q72A-4q3rA:
undetectable		 2q72A-4q3rA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA801_1
(TRANSPORTER)		 4q3r ARGINASE
(Schistosoma
mansoni) 		5 / 12 LEU A 288
LEU A 284
ILE A 328
ALA A 271
LEU A 305
 None
 1.13A 2qb4A-4q3rA:
undetectable		 2qb4A-4q3rA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4q3r ARGINASE
(Schistosoma
mansoni) 		5 / 10 GLU A 293
ARG A 289
ILE A 238
GLY A 287
ILE A 207
 None
 1.32A 3adsA-4q3rA:
undetectable		 3adsA-4q3rA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_A_SHHA301_1
(HISTONE DEACETYLASE
7A)		 4q3r ARGINASE
(Schistosoma
mansoni) 		4 / 5 HIS A 171
ASP A 158
HIS A 156
ASP A 154
 XA2  A 407 (-3.2A)
MN  A 401 ( 2.5A)
MN  A 402 ( 3.3A)
MN  A 401 (-2.6A)
 1.22A 3c0zA-4q3rA:
13.5		 3c0zA-4q3rA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_D_ADND500_1
(ADENOSYLHOMOCYSTEINA
SE)		 4q3r ARGINASE
(Schistosoma
mansoni) 		5 / 12 HIS A 156
ASP A 264
THR A 274
GLY A 172
HIS A 171
 MN  A 402 ( 3.3A)
MN  A 402 ( 2.1A)
None
XA2  A 407 ( 3.8A)
XA2  A 407 (-3.2A)
 1.36A 3ce6D-4q3rA:
2.7		 3ce6D-4q3rA:
22.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GN0_A_DMOA551_1
(ARGINASE-1)		 4q3r ARGINASE
(Schistosoma
mansoni) 		9 / 9 HIS A 156
ASP A 158
ASN A 160
SER A 167
HIS A 171
GLY A 172
ASP A 213
GLU A 216
THR A 276
 MN  A 402 ( 3.3A)
MN  A 401 ( 2.5A)
XA2  A 407 (-4.2A)
XA2  A 407 (-2.7A)
XA2  A 407 (-3.2A)
XA2  A 407 ( 3.8A)
XA2  A 407 (-3.1A)
XA2  A 407 ( 4.3A)
XA2  A 407 (-3.6A)
 0.32A 3gn0A-4q3rA:
49.5		 3gn0A-4q3rA:
39.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GN0_B_DMOB552_1
(ARGINASE-1)		 4q3r ARGINASE
(Schistosoma
mansoni) 		9 / 9 HIS A 156
ASP A 158
ASN A 160
SER A 167
HIS A 171
GLY A 172
ASP A 213
GLU A 216
THR A 276
 MN  A 402 ( 3.3A)
MN  A 401 ( 2.5A)
XA2  A 407 (-4.2A)
XA2  A 407 (-2.7A)
XA2  A 407 (-3.2A)
XA2  A 407 ( 3.8A)
XA2  A 407 (-3.1A)
XA2  A 407 ( 4.3A)
XA2  A 407 (-3.6A)
 0.35A 3gn0B-4q3rA:
49.4		 3gn0B-4q3rA:
39.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA424_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4q3r ARGINASE
(Schistosoma
mansoni) 		4 / 8 ARG A 289
PRO A 123
SER A 121
GLY A 334
 None
 1.14A 3hcrA-4q3rA:
3.1		 3hcrA-4q3rA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_D_SAMD301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 4q3r ARGINASE
(Schistosoma
mansoni) 		5 / 12 GLY A 157
SER A 176
ILE A 220
ASP A 211
LEU A 212
 None
None
None
XA2  A 407 (-3.8A)
None
 1.07A 3iv6D-4q3rA:
3.8		 3iv6D-4q3rA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 4q3r ARGINASE
(Schistosoma
mansoni) 		5 / 9 LEU A 333
VAL A 127
LEU A  46
PHE A  52
VAL A  56
 None
 1.43A 3jwqA-4q3rA:
undetectable		 3jwqA-4q3rA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA302_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 4q3r ARGINASE
(Schistosoma
mansoni) 		4 / 6 LEU A 288
GLU A 292
ARG A 337
HIS A 335
 None
None
None
CSO  A 336 ( 3.4A)
 0.91A 3ltwA-4q3rA:
undetectable		 3ltwA-4q3rA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_C_ADNC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 4q3r ARGINASE
(Schistosoma
mansoni) 		5 / 12 HIS A 156
ASP A 264
THR A 274
GLY A 172
HIS A 171
 MN  A 402 ( 3.3A)
MN  A 402 ( 2.1A)
None
XA2  A 407 ( 3.8A)
XA2  A 407 (-3.2A)
 1.36A 3n58C-4q3rA:
2.2		 3n58C-4q3rA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_A_ADNA506_1
(ADENOSYLHOMOCYSTEINA
SE)		 4q3r ARGINASE
(Schistosoma
mansoni) 		5 / 12 HIS A 156
ASP A 264
THR A 274
GLY A 172
HIS A 171
 MN  A 402 ( 3.3A)
MN  A 402 ( 2.1A)
None
XA2  A 407 ( 3.8A)
XA2  A 407 (-3.2A)
 1.38A 3ondA-4q3rA:
undetectable		 3ondA-4q3rA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_B_ADNB507_1
(ADENOSYLHOMOCYSTEINA
SE)		 4q3r ARGINASE
(Schistosoma
mansoni) 		5 / 12 HIS A 156
ASP A 264
THR A 274
GLY A 172
HIS A 171
 MN  A 402 ( 3.3A)
MN  A 402 ( 2.1A)
None
XA2  A 407 ( 3.8A)
XA2  A 407 (-3.2A)
 1.38A 3ondB-4q3rA:
undetectable		 3ondB-4q3rA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4q3r ARGINASE
(Schistosoma
mansoni) 		5 / 10 PHE A  26
LEU A 333
VAL A  56
PHE A  52
VAL A 125
 None
 1.50A 3u9fI-4q3rA:
undetectable		 3u9fI-4q3rA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_3
(PROTEASE)		 4q3r ARGINASE
(Schistosoma
mansoni) 		3 / 3 ASP A 154
ASP A 158
ASN A 169
 MN  A 401 (-2.6A)
MN  A 401 ( 2.5A)
None
 0.76A 4q5mA-4q3rA:
undetectable		 4q5mA-4q3rA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA301_0
(THAUMATIN-1)		 4q3r ARGINASE
(Schistosoma
mansoni) 		3 / 3 THR A 161
ASN A 164
SER A 165
 None
None
XA2  A 407 ( 4.4A)
 0.70A 4tvtA-4q3rA:
undetectable		 4tvtA-4q3rA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U14_A_0HKA2000_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M3)		 4q3r ARGINASE
(Schistosoma
mansoni) 		5 / 12 ILE A 290
TRP A 152
THR A 137
ALA A 306
CYH A 332
 None
 1.50A 4u14A-4q3rA:
undetectable		 4u14A-4q3rA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4q3r ARGINASE
(Schistosoma
mansoni) 		5 / 12 HIS A 156
ASP A 264
THR A 274
GLY A 172
HIS A 171
 MN  A 402 ( 3.3A)
MN  A 402 ( 2.1A)
None
XA2  A 407 ( 3.8A)
XA2  A 407 (-3.2A)
 1.38A 5axdA-4q3rA:
2.2		 5axdA-4q3rA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4q3r ARGINASE
(Schistosoma
mansoni) 		5 / 12 HIS A 156
ASP A 264
THR A 274
GLY A 172
HIS A 171
 MN  A 402 ( 3.3A)
MN  A 402 ( 2.1A)
None
XA2  A 407 ( 3.8A)
XA2  A 407 (-3.2A)
 1.38A 5axdC-4q3rA:
2.3		 5axdC-4q3rA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_A_X6XA202_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 4q3r ARGINASE
(Schistosoma
mansoni) 		4 / 8 GLU A 286
GLY A 281
GLY A 280
VAL A 233
 None
 0.78A 5f8yA-4q3rA:
undetectable		 5f8yA-4q3rA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_B_X6XB201_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 4q3r ARGINASE
(Schistosoma
mansoni) 		4 / 8 GLU A 286
GLY A 281
GLY A 280
VAL A 233
 None
 0.77A 5f8yB-4q3rA:
undetectable		 5f8yB-4q3rA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_A_SAMA301_0
(PANTOTHENATE
SYNTHETASE)		 4q3r ARGINASE
(Schistosoma
mansoni) 		5 / 12 GLY A 281
LEU A 282
VAL A 303
GLY A 208
ASP A 154
 None
None
None
None
MN  A 401 (-2.6A)
 1.20A 5hg0A-4q3rA:
undetectable		 5hg0A-4q3rA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_C_IPHC101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 4q3r ARGINASE
(Schistosoma
mansoni) 		4 / 6 CYH A 332
CYH A 291
LEU A 259
LEU A 300
 None
 1.20A 5hpuC-4q3rA:
undetectable
5hpuD-4q3rA:
undetectable		 5hpuC-4q3rA:
6.94
5hpuD-4q3rA:
6.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 4q3r ARGINASE
(Schistosoma
mansoni) 		5 / 12 ILE A 290
ASP A 158
ALA A 306
GLY A 275
THR A 276
 None
MN  A 401 ( 2.5A)
None
None
XA2  A 407 (-3.6A)
 1.10A 5igiA-4q3rA:
undetectable		 5igiA-4q3rA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 4q3r ARGINASE
(Schistosoma
mansoni) 		5 / 12 PRO A  71
SER A 132
HIS A 131
GLY A 128
GLY A  43
 None
None
MN  A 401 ( 3.2A)
None
None
 1.13A 5l6eA-4q3rA:
1.6		 5l6eA-4q3rA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4q3r ARGINASE
(Schistosoma
mansoni) 		5 / 12 HIS A 156
ASP A 264
THR A 274
GLY A 172
HIS A 171
 MN  A 402 ( 3.3A)
MN  A 402 ( 2.1A)
None
XA2  A 407 ( 3.8A)
XA2  A 407 (-3.2A)
 1.33A 5m5kB-4q3rA:
undetectable		 5m5kB-4q3rA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4q3r ARGINASE
(Schistosoma
mansoni) 		5 / 12 HIS A 156
ASP A 264
THR A 274
GLY A 172
HIS A 171
 MN  A 402 ( 3.3A)
MN  A 402 ( 2.1A)
None
XA2  A 407 ( 3.8A)
XA2  A 407 (-3.2A)
 1.38A 5m66A-4q3rA:
undetectable		 5m66A-4q3rA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4q3r ARGINASE
(Schistosoma
mansoni) 		5 / 12 HIS A 156
ASP A 264
THR A 274
GLY A 172
HIS A 171
 MN  A 402 ( 3.3A)
MN  A 402 ( 2.1A)
None
XA2  A 407 ( 3.8A)
XA2  A 407 (-3.2A)
 1.36A 5m66C-4q3rA:
2.7		 5m66C-4q3rA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4q3r ARGINASE
(Schistosoma
mansoni) 		4 / 8 HIS A 156
ASP A 158
THR A  31
ASP A 262
 MN  A 402 ( 3.3A)
MN  A 401 ( 2.5A)
None
MN  A 402 (-2.8A)
 1.05A 5t8sB-4q3rA:
undetectable		 5t8sB-4q3rA:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_F_ADNF503_1
(ADENOSYLHOMOCYSTEINA
SE)		 4q3r ARGINASE
(Schistosoma
mansoni) 		5 / 12 HIS A 156
ASP A 264
THR A 274
GLY A 172
HIS A 171
 MN  A 402 ( 3.3A)
MN  A 402 ( 2.1A)
None
XA2  A 407 ( 3.8A)
XA2  A 407 (-3.2A)
 1.37A 5utuF-4q3rA:
undetectable		 5utuF-4q3rA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 4q3r ARGINASE
(Schistosoma
mansoni) 		5 / 12 ALA A 134
GLY A 140
ASP A 262
ALA A 306
PRO A 174
 None
None
MN  A 402 (-2.8A)
None
None
 1.06A 5zvgA-4q3rA:
2.2		 5zvgA-4q3rA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 4q3r ARGINASE
(Schistosoma
mansoni) 		5 / 12 ALA A 134
GLY A 140
ASP A 262
ALA A 306
PRO A 174
 None
None
MN  A 402 (-2.8A)
None
None
 1.04A 5zvgB-4q3rA:
3.4		 5zvgB-4q3rA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_B_ADNB505_1
(-)		 4q3r ARGINASE
(Schistosoma
mansoni) 		5 / 12 HIS A 156
ASP A 264
THR A 274
GLY A 172
HIS A 171
 MN  A 402 ( 3.3A)
MN  A 402 ( 2.1A)
None
XA2  A 407 ( 3.8A)
XA2  A 407 (-3.2A)
 1.34A 6f3nB-4q3rA:
2.1		 6f3nB-4q3rA:
20.78