SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4q48'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_0
(FTSJ)		 4q48 DNA HELICASE RECQ
(Deinococcus
radiodurans) 		5 / 12 ALA A  42
GLY A  39
GLY A  40
LEU A  61
LEU A  62
 None
 0.73A 1eizA-4q48A:
2.1		 1eizA-4q48A:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_0
(FTSJ)		 4q48 DNA HELICASE RECQ
(Deinococcus
radiodurans) 		5 / 12 ALA A  42
GLY A  39
GLY A  40
LEU A  62
LEU A 117
 None
 0.92A 1eizA-4q48A:
2.1		 1eizA-4q48A:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_0
(FTSJ)		 4q48 DNA HELICASE RECQ
(Deinococcus
radiodurans) 		6 / 12 ALA A  42
GLY A  39
GLY A  40
LEU A  61
LEU A  62
LEU A 117
 None
 1.13A 1ej0A-4q48A:
undetectable		 1ej0A-4q48A:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTV_A_TESA500_1
(17
BETA-HYDROXYSTEROID
DEHYDROGENASE TYPE 1)		 4q48 DNA HELICASE RECQ
(Deinococcus
radiodurans) 		4 / 8 VAL A  89
LEU A 117
TYR A  56
SER A  53
 None
 1.19A 1jtvA-4q48A:
2.4		 1jtvA-4q48A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA141_0
(LYSOZYME C)		 4q48 DNA HELICASE RECQ
(Deinococcus
radiodurans) 		4 / 6 ASP A 330
GLY A 331
PRO A 333
SER A 334
 None
 0.79A 1n4fA-4q48A:
undetectable		 1n4fA-4q48A:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_1
(ESTROGEN RECEPTOR
BETA)		 4q48 DNA HELICASE RECQ
(Deinococcus
radiodurans) 		5 / 12 LEU A 179
THR A 180
ALA A 147
LEU A 195
ILE A  32
 None
 0.86A 1qknA-4q48A:
undetectable		 1qknA-4q48A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_0
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 4q48 DNA HELICASE RECQ
(Deinococcus
radiodurans) 		5 / 12 THR A 324
ILE A 289
GLY A 239
GLY A 287
HIS A 234
 None
 0.99A 2fk8A-4q48A:
3.0		 2fk8A-4q48A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA601_1
(SERUM ALBUMIN)		 4q48 DNA HELICASE RECQ
(Deinococcus
radiodurans) 		5 / 12 LEU A 387
CYH A 381
GLY A 399
CYH A 404
SER A 206
 None
ZN  A 801 (-2.3A)
ZN  A 801 (-4.6A)
ZN  A 801 (-2.3A)
None
 1.42A 4ot2A-4q48A:
undetectable		 4ot2A-4q48A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_0
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 4q48 DNA HELICASE RECQ
(Deinococcus
radiodurans) 		5 / 12 ARG A 329
GLY A 325
PHE A 207
ALA A 181
GLN A 322
 None
 1.33A 4ryaA-4q48A:
undetectable		 4ryaA-4q48A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_B_SALB801_1
(PROTEIN POLYBROMO-1)		 4q48 DNA HELICASE RECQ
(Deinococcus
radiodurans) 		4 / 5 LEU A 164
TYR A 161
ALA A 147
ILE A 191
 None
 1.15A 4y03B-4q48A:
undetectable		 4y03B-4q48A:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA602_1
(SERUM ALBUMIN)		 4q48 DNA HELICASE RECQ
(Deinococcus
radiodurans) 		5 / 12 LEU A 387
CYH A 381
GLY A 399
CYH A 404
SER A 206
 None
ZN  A 801 (-2.3A)
ZN  A 801 (-4.6A)
ZN  A 801 (-2.3A)
None
 1.42A 4zbrA-4q48A:
undetectable		 4zbrA-4q48A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZGF_A_BEZA210_0
(UNCHARACTERIZED
PROTEIN)		 4q48 DNA HELICASE RECQ
(Deinococcus
radiodurans) 		4 / 4 VAL A  44
ALA A  42
ASN A  41
GLN A  35
 None
 1.35A 4zgfA-4q48A:
undetectable		 4zgfA-4q48A:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_1
(PROTEIN-TYROSINE
KINASE 6)		 4q48 DNA HELICASE RECQ
(Deinococcus
radiodurans) 		6 / 12 LEU A 195
ALA A 147
LEU A  45
THR A 180
GLU A 198
LEU A  43
 None
 1.35A 5h2uA-4q48A:
undetectable		 5h2uA-4q48A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_E_SAME501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4q48 DNA HELICASE RECQ
(Deinococcus
radiodurans) 		5 / 9 GLY A 432
SER A 422
VAL A 439
LEU A 440
ARG A 443
 None
 1.39A 5o96E-4q48A:
undetectable
5o96F-4q48A:
undetectable		 5o96E-4q48A:
19.05
5o96F-4q48A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TDM_A_ADNA904_1
(ATP-CITRATE SYNTHASE)		 4q48 DNA HELICASE RECQ
(Deinococcus
radiodurans) 		4 / 4 THR A 130
ASP A 132
ARG A 136
LEU A 134
 None
 1.08A 5tdmA-4q48A:
undetectable		 5tdmA-4q48A:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_A_HISA402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 4q48 DNA HELICASE RECQ
(Deinococcus
radiodurans) 		5 / 10 GLY A 442
LEU A 441
THR A 458
VAL A 461
ALA A 423
 None
 1.11A 6czmA-4q48A:
undetectable
6czmC-4q48A:
undetectable		 6czmA-4q48A:
23.33
6czmC-4q48A:
23.33