SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4q4a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_0
(ALCOHOL
DEHYDROGENASE)		 4q4a UNCHARACTERIZED ABC
TRANSPORTER
ATP-BINDING PROTEIN
TM_0288
(Thermotoga
maritima) 		3 / 3 MET B 101
LEU B 104
SER B 105
 None
 0.46A 1ee2A-4q4aB:
undetectable		 1ee2A-4q4aB:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O76_B_CAMB1420_0
(CYTOCHROME P450-CAM)		 4q4a UNCHARACTERIZED ABC
TRANSPORTER
ATP-BINDING PROTEIN
TM_0288
(Thermotoga
maritima) 		4 / 8 PHE B 473
THR B 503
LEU B 449
VAL B 445
 None
 1.14A 1o76B-4q4aB:
undetectable		 1o76B-4q4aB:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_C_DESC129_1
(TRANSTHYRETIN)		 4q4a UNCHARACTERIZED ABC
TRANSPORTER
ATP-BINDING PROTEIN
TM_0288
(Thermotoga
maritima) 		4 / 6 LEU B 165
ALA B 168
SER B  50
SER B  49
 None
 0.97A 1tz8C-4q4aB:
undetectable
1tz8D-4q4aB:
undetectable		 1tz8C-4q4aB:
11.87
1tz8D-4q4aB:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UYU_A_CAMA1416_0
(CYTOCHROME P450-CAM)		 4q4a UNCHARACTERIZED ABC
TRANSPORTER
ATP-BINDING PROTEIN
TM_0288
(Thermotoga
maritima) 		4 / 8 PHE B 473
THR B 503
LEU B 449
VAL B 445
 None
 1.19A 1uyuA-4q4aB:
undetectable		 1uyuA-4q4aB:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UYU_B_CAMB1416_0
(CYTOCHROME P450-CAM)		 4q4a UNCHARACTERIZED ABC
TRANSPORTER
ATP-BINDING PROTEIN
TM_0288
(Thermotoga
maritima) 		4 / 8 PHE B 473
THR B 503
LEU B 449
VAL B 445
 None
 1.14A 1uyuB-4q4aB:
undetectable		 1uyuB-4q4aB:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_B_BEZB12_0
(CES1 PROTEIN)		 4q4a UNCHARACTERIZED ABC
TRANSPORTER
ATP-BINDING PROTEIN
TM_0288
(Thermotoga
maritima) 		4 / 4 GLY B 388
SER B 392
VAL B 568
LEU B 586
 None
 1.05A 1yajB-4q4aB:
undetectable		 1yajB-4q4aB:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUH_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 4q4a UNCHARACTERIZED ABC
TRANSPORTER
ATP-BINDING PROTEIN
TM_0288
(Thermotoga
maritima) 		4 / 6 PHE B 473
THR B 503
LEU B 449
VAL B 445
 None
 1.11A 2zuhA-4q4aB:
undetectable		 2zuhA-4q4aB:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEC_A_STIA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4q4a UNCHARACTERIZED ABC
TRANSPORTER
ATP-BINDING PROTEIN
TM_0288
(Thermotoga
maritima) 		4 / 4 LEU B 558
MET B 538
ILE B 412
ASP B 415
 None
 1.46A 3hecA-4q4aB:
undetectable		 3hecA-4q4aB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4q4a UNCHARACTERIZED ABC
TRANSPORTER
ATP-BINDING PROTEIN
TM_0288
(Thermotoga
maritima) 		5 / 11 SER B 426
LEU B 427
SER B 430
ILE B 417
VAL B 414
 None
 1.01A 3w67A-4q4aB:
undetectable		 3w67A-4q4aB:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4q4a UNCHARACTERIZED ABC
TRANSPORTER
ATP-BINDING PROTEIN
TM_0288
(Thermotoga
maritima) 		6 / 12 SER B 426
LEU B 427
SER B 430
ILE B 417
VAL B 414
VAL B 351
 None
 1.18A 3w68A-4q4aB:
undetectable		 3w68A-4q4aB:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_30ZA1920_1
(ANDROGEN RECEPTOR)		 4q4a UNCHARACTERIZED ABC
TRANSPORTER
ATP-BINDING PROTEIN
TM_0288
(Thermotoga
maritima) 		4 / 6 GLY B 213
ASN B 216
ASN B 208
GLU B 207
 None
 1.02A 3zqtA-4q4aB:
undetectable		 3zqtA-4q4aB:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_A_CP6A201_1
(DIHYDROFOLATE
REDUCTASE)		 4q4a UNCHARACTERIZED ABC
TRANSPORTER
ATP-BINDING PROTEIN
TM_0288
(Thermotoga
maritima) 		5 / 10 ILE B 530
ALA B 518
LEU B 513
ILE B 502
THR B 519
 None
 1.33A 4km0A-4q4aB:
undetectable		 4km0A-4q4aB:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4C_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 4q4a UNCHARACTERIZED ABC
TRANSPORTER
ATP-BINDING PROTEIN
TM_0288
(Thermotoga
maritima) 		4 / 8 PHE B 473
THR B 503
LEU B 449
VAL B 445
 None
 1.01A 4l4cB-4q4aB:
undetectable		 4l4cB-4q4aB:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4D_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 4q4a UNCHARACTERIZED ABC
TRANSPORTER
ATP-BINDING PROTEIN
TM_0288
(Thermotoga
maritima) 		4 / 8 PHE B 473
THR B 503
LEU B 449
VAL B 445
 None
 1.04A 4l4dA-4q4aB:
undetectable		 4l4dA-4q4aB:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4E_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 4q4a UNCHARACTERIZED ABC
TRANSPORTER
ATP-BINDING PROTEIN
TM_0288
(Thermotoga
maritima) 		4 / 8 PHE B 473
THR B 503
LEU B 449
VAL B 445
 None
 1.12A 4l4eA-4q4aB:
undetectable		 4l4eA-4q4aB:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4F_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 4q4a UNCHARACTERIZED ABC
TRANSPORTER
ATP-BINDING PROTEIN
TM_0288
(Thermotoga
maritima) 		4 / 8 PHE B 473
THR B 503
LEU B 449
VAL B 445
 None
 1.13A 4l4fA-4q4aB:
undetectable		 4l4fA-4q4aB:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_A_30ZA201_1
(TRANSTHYRETIN)		 4q4a UNCHARACTERIZED ABC
TRANSPORTER
ATP-BINDING PROTEIN
TM_0288
(Thermotoga
maritima) 		4 / 6 LEU B 485
THR B 438
LEU B 492
SER B 493
 None
 0.96A 4pwjA-4q4aB:
undetectable		 4pwjA-4q4aB:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUC_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 4q4a UNCHARACTERIZED ABC
TRANSPORTER
ATP-BINDING PROTEIN
TM_0288
(Thermotoga
maritima) 		5 / 12 VAL B 522
GLU B 517
ILE B 545
ILE B 553
HIS B 548
 None
 1.41A 4xucA-4q4aB:
undetectable		 4xucA-4q4aB:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA602_1
(SERUM ALBUMIN)		 4q4a UNCHARACTERIZED ABC
TRANSPORTER
ATP-BINDING PROTEIN
TM_0288
(Thermotoga
maritima) 		4 / 8 LEU B 112
ASP B 143
ASN B 146
VAL B 150
 None
 0.74A 4zbqA-4q4aB:
undetectable		 4zbqA-4q4aB:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_S_BEZS801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4q4a UNCHARACTERIZED ABC
TRANSPORTER
ATP-BINDING PROTEIN
TM_0288
(Thermotoga
maritima) 		4 / 6 PHE B 506
SER B 470
LEU B 449
LEU B 507
 None
 1.21A 5dzke-4q4aB:
2.9
5dzks-4q4aB:
undetectable		 5dzke-4q4aB:
15.47
5dzks-4q4aB:
6.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 4q4a UNCHARACTERIZED ABC
TRANSPORTER
ATP-BINDING PROTEIN
TM_0288
(Thermotoga
maritima) 		3 / 3 THR B 542
ASP B 415
GLU B 350
 None
 0.75A 5fa8A-4q4aB:
undetectable		 5fa8A-4q4aB:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 4q4a UNCHARACTERIZED ABC
TRANSPORTER
ATP-BINDING PROTEIN
TM_0288
(Thermotoga
maritima) 		5 / 10 LEU B  93
THR B  90
SER B  50
GLY B  53
ILE B  51
 None
 1.18A 6ebpC-4q4aB:
2.4		 6ebpC-4q4aB:
9.34