SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4q4g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_D_ESTD352_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 4q4g PEPTIDOGLYCAN
ENDOPEPTIDASE RIPA
(Mycobacterium
tuberculosis) 		4 / 6 SER X1090
GLY X1088
LEU X1124
TYR X1127
 None
 0.94A 1fduD-4q4gX:
undetectable		 1fduD-4q4gX:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 4q4g PEPTIDOGLYCAN
ENDOPEPTIDASE RIPA
(Mycobacterium
tuberculosis) 		5 / 12 THR X1116
GLY X1118
GLY X1100
GLY X1099
GLY X1187
 None
 0.89A 1n2xB-4q4gX:
undetectable		 1n2xB-4q4gX:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7R_A_NCTA440_1
(CYTOCHROME P450-CAM)		 4q4g PEPTIDOGLYCAN
ENDOPEPTIDASE RIPA
(Mycobacterium
tuberculosis) 		4 / 7 THR X1172
VAL X1195
VAL X1204
ASP X1159
 None
 0.99A 1p7rA-4q4gX:
undetectable		 1p7rA-4q4gX:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_B_ESTB2_1
(ESTROGEN RECEPTOR)		 4q4g PEPTIDOGLYCAN
ENDOPEPTIDASE RIPA
(Mycobacterium
tuberculosis) 		5 / 10 LEU X1188
ALA X1183
GLU X1182
LEU X1009
ARG X1196
 None
 1.48A 1pcgB-4q4gX:
undetectable		 1pcgB-4q4gX:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKT_A_ESTA600_1
(ESTRADIOL RECEPTOR)		 4q4g PEPTIDOGLYCAN
ENDOPEPTIDASE RIPA
(Mycobacterium
tuberculosis) 		5 / 10 LEU X1188
ALA X1183
GLU X1182
LEU X1009
ARG X1196
 None
 1.48A 1qktA-4q4gX:
undetectable		 1qktA-4q4gX:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYS_A_ACTA402_0
(MCCC FAMILY PROTEIN)		 4q4g PEPTIDOGLYCAN
ENDOPEPTIDASE RIPA
(Mycobacterium
tuberculosis) 		4 / 6 ASP X1185
ASP X1006
ARG X1196
GLU X1182
 None
 1.24A 4eysA-4q4gX:
undetectable		 4eysA-4q4gX:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 4q4g PEPTIDOGLYCAN
ENDOPEPTIDASE RIPA
(Mycobacterium
tuberculosis) 		5 / 12 GLY X1118
GLY X1100
GLY X1101
THR X1034
GLY X1109
 None
 0.82A 4o33A-4q4gX:
undetectable		 4o33A-4q4gX:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 4q4g PEPTIDOGLYCAN
ENDOPEPTIDASE RIPA
(Mycobacterium
tuberculosis) 		5 / 12 GLY X1118
GLY X1100
GLY X1101
THR X1034
GLY X1109
 None
 0.79A 4o3fA-4q4gX:
undetectable		 4o3fA-4q4gX:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_1
(HYDG PROTEIN)		 4q4g PEPTIDOGLYCAN
ENDOPEPTIDASE RIPA
(Mycobacterium
tuberculosis) 		3 / 3 GLU X1182
ARG X1191
GLN X1169
 None
 0.79A 4rtbA-4q4gX:
undetectable		 4rtbA-4q4gX:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_B_ESTB1000_1
(ESTROGEN RECEPTOR)		 4q4g PEPTIDOGLYCAN
ENDOPEPTIDASE RIPA
(Mycobacterium
tuberculosis) 		5 / 10 LEU X1188
ALA X1183
GLU X1182
LEU X1009
ARG X1196
 None
 1.48A 5dxeB-4q4gX:
undetectable		 5dxeB-4q4gX:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A211_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 4q4g PEPTIDOGLYCAN
ENDOPEPTIDASE RIPA
(Mycobacterium
tuberculosis) 		4 / 6 VAL X1024
ALA X1033
GLN X1037
VAL X1038
 None
 0.95A 5i8fA-4q4gX:
undetectable		 5i8fA-4q4gX:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGK_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4q4g PEPTIDOGLYCAN
ENDOPEPTIDASE RIPA
(Mycobacterium
tuberculosis) 		3 / 3 VAL X1205
TYR X1144
GLN X1143
 None
 0.75A 5qgkA-4q4gX:
undetectable		 5qgkA-4q4gX:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGO_A_ACTA302_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4q4g PEPTIDOGLYCAN
ENDOPEPTIDASE RIPA
(Mycobacterium
tuberculosis) 		4 / 4 VAL X1204
VAL X1205
TYR X1144
GLN X1143
 None
 1.25A 5qgoA-4q4gX:
undetectable		 5qgoA-4q4gX:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGP_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4q4g PEPTIDOGLYCAN
ENDOPEPTIDASE RIPA
(Mycobacterium
tuberculosis) 		4 / 4 VAL X1204
VAL X1205
TYR X1144
GLN X1143
 None
 1.27A 5qgpA-4q4gX:
undetectable		 5qgpA-4q4gX:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGR_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4q4g PEPTIDOGLYCAN
ENDOPEPTIDASE RIPA
(Mycobacterium
tuberculosis) 		3 / 3 VAL X1205
TYR X1144
GLN X1143
 None
 0.71A 5qgrA-4q4gX:
undetectable		 5qgrA-4q4gX:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGT_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4q4g PEPTIDOGLYCAN
ENDOPEPTIDASE RIPA
(Mycobacterium
tuberculosis) 		3 / 3 VAL X1205
TYR X1144
GLN X1143
 None
 0.74A 5qgtA-4q4gX:
undetectable		 5qgtA-4q4gX:
18.92