SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4q57'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CTR_A_TFPA153_1
(CALMODULIN)		 4q57 CALMODULIN
(Homo
sapiens) 		5 / 9 ILE A  27
LEU A  32
MET A  51
GLU A  54
MET A  71
 None
 0.91A 1ctrA-4q57A:
13.1		 1ctrA-4q57A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		 4q57 CALMODULIN
(Homo
sapiens) 		7 / 11 PHE A  19
ILE A  27
LEU A  32
LEU A  39
MET A  51
VAL A  55
MET A  71
 None
 0.62A 1dtlA-4q57A:
11.7		 1dtlA-4q57A:
42.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		 4q57 CALMODULIN
(Homo
sapiens) 		7 / 11 PHE A  19
ILE A  27
LEU A  32
MET A  36
MET A  51
VAL A  55
MET A  71
 None
 0.66A 1dtlA-4q57A:
11.7		 1dtlA-4q57A:
42.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		 4q57 CALMODULIN
(Homo
sapiens) 		4 / 8 MET A  36
GLN A  41
PRO A  43
GLU A  47
 None
 0.71A 1dtlA-4q57A:
11.7		 1dtlA-4q57A:
42.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4q57 CALMODULIN
(Homo
sapiens) 		6 / 12 PHE A  19
ILE A  27
LEU A  32
MET A  36
ILE A  52
GLU A  54
 None
 0.85A 1lxfC-4q57A:
8.8		 1lxfC-4q57A:
55.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WRK_A_TFPA202_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4q57 CALMODULIN
(Homo
sapiens) 		5 / 10 MET A  36
LEU A  39
GLN A  41
GLU A  47
MET A  51
 None
 0.47A 1wrkA-4q57A:
10.2
1wrkB-4q57A:
10.4		 1wrkA-4q57A:
55.70
1wrkB-4q57A:
55.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WRL_A_TFPA202_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4q57 CALMODULIN
(Homo
sapiens) 		5 / 9 MET A  36
LEU A  39
GLN A  41
GLU A  47
MET A  51
 None
 0.36A 1wrlA-4q57A:
10.4
1wrlB-4q57A:
10.3		 1wrlA-4q57A:
55.70
1wrlB-4q57A:
55.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WRL_B_TFPB201_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4q57 CALMODULIN
(Homo
sapiens) 		5 / 9 MET A  36
LEU A  39
GLN A  41
GLU A  47
MET A  51
 None
 0.37A 1wrlA-4q57A:
10.4
1wrlB-4q57A:
10.3		 1wrlA-4q57A:
55.70
1wrlB-4q57A:
55.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WRL_C_TFPC206_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4q57 CALMODULIN
(Homo
sapiens) 		5 / 9 MET A  36
LEU A  39
GLN A  41
GLU A  47
MET A  51
 None
 0.49A 1wrlC-4q57A:
10.2
1wrlD-4q57A:
10.3		 1wrlC-4q57A:
55.70
1wrlD-4q57A:
55.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WRL_D_TFPD205_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4q57 CALMODULIN
(Homo
sapiens) 		5 / 10 MET A  36
LEU A  39
GLN A  41
GLU A  47
MET A  51
 None
 0.30A 1wrlC-4q57A:
10.2
1wrlD-4q57A:
10.3		 1wrlC-4q57A:
55.70
1wrlD-4q57A:
55.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WRL_E_TFPE210_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4q57 CALMODULIN
(Homo
sapiens) 		5 / 9 MET A  36
LEU A  39
GLN A  41
GLU A  47
MET A  51
 None
 0.40A 1wrlE-4q57A:
10.3
1wrlF-4q57A:
10.3		 1wrlE-4q57A:
55.70
1wrlF-4q57A:
55.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WRL_F_TFPF209_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4q57 CALMODULIN
(Homo
sapiens) 		5 / 10 MET A  36
LEU A  39
GLN A  41
GLU A  47
MET A  51
 None
 0.42A 1wrlE-4q57A:
10.3
1wrlF-4q57A:
10.3		 1wrlE-4q57A:
55.70
1wrlF-4q57A:
55.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RJD_A_TFPA203_1
(CALMODULIN)		 4q57 CALMODULIN
(Homo
sapiens) 		4 / 8 PHE A  19
ILE A  27
LEU A  32
MET A  51
 None
 0.38A 4rjdA-4q57A:
13.8		 4rjdA-4q57A:
46.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RJD_A_TFPA203_1
(CALMODULIN)		 4q57 CALMODULIN
(Homo
sapiens) 		4 / 8 PHE A  19
ILE A  27
LEU A  32
MET A  71
 None
 0.47A 4rjdA-4q57A:
13.8		 4rjdA-4q57A:
46.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RJD_B_TFPB203_1
(CALMODULIN)		 4q57 CALMODULIN
(Homo
sapiens) 		5 / 7 PHE A  19
LEU A  32
MET A  36
MET A  71
MET A  72
 None
 1.06A 4rjdB-4q57A:
13.8		 4rjdB-4q57A:
46.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RJD_B_TFPB203_1
(CALMODULIN)		 4q57 CALMODULIN
(Homo
sapiens) 		5 / 7 PHE A  19
LEU A  32
MET A  51
MET A  71
MET A  72
 None
 0.68A 4rjdB-4q57A:
13.8		 4rjdB-4q57A:
46.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V02_R_657R201_0
(CALMODULIN-1
SMALL CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
PROTEIN 2)		 4q57 CALMODULIN
(Homo
sapiens) 		5 / 10 LEU A  32
MET A  51
GLU A  54
VAL A  55
MET A  72
 None
 1.12A 5v02B-4q57A:
undetectable
5v02R-4q57A:
12.8		 5v02B-4q57A:
17.65
5v02R-4q57A:
100.00