SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4q58'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K5Q_B_PACB559_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 4q58 INTEGRIN BETA-4
(Homo
sapiens) 		4 / 7 SER C1221
PRO C1220
TYR C1253
ALA C1244
 None
 0.99A 1k5qA-4q58C:
undetectable
1k5qB-4q58C:
undetectable		 1k5qA-4q58C:
19.18
1k5qB-4q58C:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_A_NCTA1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4q58 PLECTIN
(Homo
sapiens) 		4 / 8 TYR A 254
TRP A 167
LEU A 230
MET A 262
 None
 1.36A 1uw6A-4q58A:
undetectable
1uw6B-4q58A:
undetectable		 1uw6A-4q58A:
23.81
1uw6B-4q58A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_D_NCTD1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4q58 PLECTIN
(Homo
sapiens) 		4 / 8 TYR A 254
TRP A 167
LEU A 230
MET A 262
 None
 1.37A 1uw6D-4q58A:
undetectable
1uw6E-4q58A:
undetectable		 1uw6D-4q58A:
23.81
1uw6E-4q58A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_P_NCTP1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4q58 PLECTIN
(Homo
sapiens) 		4 / 8 TYR A 254
TRP A 167
LEU A 230
MET A 262
 None
 1.36A 1uw6P-4q58A:
undetectable
1uw6Q-4q58A:
undetectable		 1uw6P-4q58A:
23.81
1uw6Q-4q58A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_T_NCTT1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4q58 PLECTIN
(Homo
sapiens) 		4 / 8 TRP A 167
LEU A 230
MET A 262
TYR A 254
 None
 1.34A 1uw6P-4q58A:
undetectable
1uw6T-4q58A:
undetectable		 1uw6P-4q58A:
23.81
1uw6T-4q58A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4q58 PLECTIN
(Homo
sapiens) 		3 / 3 LYS A  46
ASP A 189
ASP A 240
 None
 1.01A 2br4D-4q58A:
undetectable		 2br4D-4q58A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH8_A_VIBA1_1
(MAJOR PRION PROTEIN)		 4q58 INTEGRIN BETA-4
(Homo
sapiens) 		4 / 6 PRO C1154
MET C1155
ASP C1175
TYR C1157
 None
 1.31A 2lh8A-4q58C:
undetectable		 2lh8A-4q58C:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4q58 PLECTIN
(Homo
sapiens) 		5 / 12 ILE A 120
ILE A 125
GLY A  73
LEU A  79
LEU A 110
 None
 1.03A 3em0B-4q58A:
undetectable		 3em0B-4q58A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FXR_A_ASCA3001_0
(LYSR TYPE REGULATOR
OF TSAMBCD)		 4q58 INTEGRIN BETA-4
(Homo
sapiens) 		4 / 8 ARG C1301
ALA C1252
ILE C1250
PRO C1220
 None
 0.98A 3fxrA-4q58C:
undetectable		 3fxrA-4q58C:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_2
(CYTOCHROME P450 3A4)		 4q58 PLECTIN
(Homo
sapiens) 		4 / 7 ARG A 111
ILE A 120
LEU A  76
ARG A 113
 None
 1.00A 3nxuA-4q58A:
undetectable		 3nxuA-4q58A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4q58 PLECTIN
(Homo
sapiens) 		4 / 7 ASP A 237
THR A  47
LEU A 219
GLN A 221
 None
 0.97A 4ib4A-4q58A:
undetectable		 4ib4A-4q58A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2O_B_CLQB1079_0
(SAPOSIN-B)		 4q58 PLECTIN
(Homo
sapiens) 		3 / 3 MET A 158
GLU A 162
LEU A 166
 None
 0.58A 4v2oB-4q58A:
undetectable		 4v2oB-4q58A:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_2
(CYTOCHROME P450 3A4)		 4q58 PLECTIN
(Homo
sapiens) 		4 / 7 ARG A 111
ILE A 120
LEU A  76
ARG A 113
 None
 0.89A 5vc0A-4q58A:
undetectable		 5vc0A-4q58A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4q58 PLECTIN
(Homo
sapiens) 		5 / 10 ILE A 137
ILE A 141
LEU A 142
ILE A 125
ASN A 129
 None
 1.30A 5vkqA-4q58A:
undetectable
5vkqD-4q58A:
undetectable		 5vkqA-4q58A:
9.02
5vkqD-4q58A:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4q58 PLECTIN
(Homo
sapiens) 		5 / 10 ILE A 125
ASN A 129
ILE A 137
ILE A 141
LEU A 142
 None
 1.30A 5vkqA-4q58A:
undetectable
5vkqB-4q58A:
undetectable		 5vkqA-4q58A:
9.02
5vkqB-4q58A:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4q58 PLECTIN
(Homo
sapiens) 		5 / 10 ILE A 125
ASN A 129
ILE A 137
ILE A 141
LEU A 142
 None
 1.30A 5vkqC-4q58A:
undetectable
5vkqD-4q58A:
undetectable		 5vkqC-4q58A:
9.02
5vkqD-4q58A:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9K_F_ACTF802_0
(UNCHARACTERIZED
PROTEIN)		 4q58 PLECTIN
(Homo
sapiens) 		3 / 3 TYR A 211
ALA A 195
LEU A 178
 None
 0.75A 6d9kF-4q58A:
undetectable		 6d9kF-4q58A:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_B_STRB502_1
(CYTOCHROME P450
CYP260A1)		 4q58 PLECTIN
(Homo
sapiens) 		4 / 6 LEU A  56
ALA A  59
LEU A  70
ASN A 102
 None
 0.92A 6f88B-4q58A:
undetectable		 6f88B-4q58A:
18.01