SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4q5f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GTI_A_CCSA47_0
(GLUTATHIONE
S-TRANSFERASE)		 4q5f GLUTATHIONE
S-TRANSFERASE 1
(Ascaris
suum) 		4 / 7 TRP A  39
LEU A  42
GLY A  49
LEU A  51
 GSH  A 301 (-4.0A)
None
None
GSH  A 301 (-4.8A)
 0.72A 1gtiA-4q5fA:
24.3		 1gtiA-4q5fA:
31.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4q5f GLUTATHIONE
S-TRANSFERASE 1
(Ascaris
suum) 		4 / 7 ALA A  25
PHE A  29
ARG A 201
ASN A 193
 None
 1.34A 1t9wA-4q5fA:
undetectable		 1t9wA-4q5fA:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZB7_A_NCAA901_0
(PROSTAGLANDIN
REDUCTASE 2)		 4q5f GLUTATHIONE
S-TRANSFERASE 1
(Ascaris
suum) 		4 / 5 TYR A  68
ILE A  21
LEU A  54
LEU A   6
 None
 1.04A 2zb7A-4q5fA:
undetectable		 2zb7A-4q5fA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC552_1
(GLUTAMATE
DEHYDROGENASE)		 4q5f GLUTATHIONE
S-TRANSFERASE 1
(Ascaris
suum) 		3 / 3 TYR A   8
TYR A  68
GLY A  13
 None
 0.62A 3eteB-4q5fA:
undetectable
3eteD-4q5fA:
undetectable
3eteF-4q5fA:
undetectable		 3eteB-4q5fA:
18.88
3eteD-4q5fA:
18.88
3eteF-4q5fA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K17_B_OHBB701_0
(LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 16A)		 4q5f GLUTATHIONE
S-TRANSFERASE 1
(Ascaris
suum) 		4 / 5 GLU A  16
SER A 163
ARG A  19
SER A 166
 None
 1.28A 4k17B-4q5fA:
undetectable		 4k17B-4q5fA:
15.79