SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4q5h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3O_A_DLUA399_1
(PFV INTEGRASE)		 4q5h PROTEIN KINASE OSPG
(Shigella
sonnei) 		4 / 7 TYR A 137
GLN A  71
GLU A  72
ARG A 179
 None
None
MG  A 201 ( 4.8A)
None
 1.29A 3s3oA-4q5hA:
undetectable		 3s3oA-4q5hA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYK_B_IMNB300_1
(LACTOYLGLUTATHIONE
LYASE)		 4q5h PROTEIN KINASE OSPG
(Shigella
sonnei) 		5 / 12 PHE A  79
PHE A 158
LEU A 129
GLY A 103
LEU A 153
 None
 1.02A 4kykA-4q5hA:
undetectable
4kykB-4q5hA:
undetectable		 4kykA-4q5hA:
24.63
4kykB-4q5hA:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_B_CHDB102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4q5h PROTEIN KINASE OSPG
(Shigella
sonnei) 		5 / 11 LEU A 139
GLU A 131
LEU A 129
LEU A 125
TYR A 122
 None
 0.85A 4wg0B-4q5hA:
undetectable
4wg0C-4q5hA:
undetectable
4wg0D-4q5hA:
undetectable		 4wg0B-4q5hA:
7.88
4wg0C-4q5hA:
7.88
4wg0D-4q5hA:
7.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_D_CHDD102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4q5h PROTEIN KINASE OSPG
(Shigella
sonnei) 		5 / 11 LEU A 139
GLU A 131
LEU A 129
LEU A 125
TYR A 122
 None
 0.85A 4wg0D-4q5hA:
undetectable
4wg0E-4q5hA:
undetectable
4wg0F-4q5hA:
undetectable		 4wg0D-4q5hA:
7.88
4wg0E-4q5hA:
7.88
4wg0F-4q5hA:
7.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_E_CHDE104_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4q5h PROTEIN KINASE OSPG
(Shigella
sonnei) 		5 / 11 LEU A 125
TYR A 122
GLU A 131
LEU A 129
LEU A 139
 None
 0.84A 4wg0C-4q5hA:
undetectable
4wg0D-4q5hA:
undetectable
4wg0E-4q5hA:
undetectable		 4wg0C-4q5hA:
7.88
4wg0D-4q5hA:
7.88
4wg0E-4q5hA:
7.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_F_CHDF103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4q5h PROTEIN KINASE OSPG
(Shigella
sonnei) 		5 / 11 LEU A 139
GLU A 131
LEU A 129
LEU A 125
TYR A 122
 None
 0.79A 4wg0F-4q5hA:
undetectable
4wg0G-4q5hA:
undetectable
4wg0H-4q5hA:
undetectable		 4wg0F-4q5hA:
7.88
4wg0G-4q5hA:
7.88
4wg0H-4q5hA:
7.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_G_CHDG103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4q5h PROTEIN KINASE OSPG
(Shigella
sonnei) 		5 / 11 LEU A 125
TYR A 122
GLU A 131
LEU A 129
LEU A 139
 None
 0.81A 4wg0E-4q5hA:
undetectable
4wg0F-4q5hA:
undetectable
4wg0G-4q5hA:
undetectable		 4wg0E-4q5hA:
7.88
4wg0F-4q5hA:
7.88
4wg0G-4q5hA:
7.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_I_CHDI103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4q5h PROTEIN KINASE OSPG
(Shigella
sonnei) 		5 / 11 LEU A 125
TYR A 122
GLU A 131
LEU A 129
LEU A 139
 None
 0.85A 4wg0G-4q5hA:
undetectable
4wg0H-4q5hA:
undetectable
4wg0I-4q5hA:
undetectable		 4wg0G-4q5hA:
7.88
4wg0H-4q5hA:
7.88
4wg0I-4q5hA:
7.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_J_CHDJ103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4q5h PROTEIN KINASE OSPG
(Shigella
sonnei) 		5 / 11 LEU A 139
GLU A 131
LEU A 129
LEU A 125
TYR A 122
 None
 0.84A 4wg0J-4q5hA:
undetectable
4wg0K-4q5hA:
undetectable
4wg0L-4q5hA:
undetectable		 4wg0J-4q5hA:
7.88
4wg0K-4q5hA:
7.88
4wg0L-4q5hA:
7.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_K_CHDK103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4q5h PROTEIN KINASE OSPG
(Shigella
sonnei) 		5 / 11 LEU A 125
TYR A 122
GLU A 131
LEU A 129
LEU A 139
 None
 0.83A 4wg0I-4q5hA:
undetectable
4wg0J-4q5hA:
undetectable
4wg0K-4q5hA:
undetectable		 4wg0I-4q5hA:
7.88
4wg0J-4q5hA:
7.88
4wg0K-4q5hA:
7.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP3_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 4q5h PROTEIN KINASE OSPG
(Shigella
sonnei) 		4 / 6 ALA A  84
LEU A  99
MET A  98
LEU A  96
 None
None
ANP  A 202 (-3.7A)
None
 1.26A 4xp3A-4q5hA:
5.4		 4xp3A-4q5hA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_F_EY4F500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4q5h PROTEIN KINASE OSPG
(Shigella
sonnei) 		4 / 7 ALA A  39
THR A  38
ILE A 156
PRO A 105
 ANP  A 202 (-4.3A)
ANP  A 202 (-4.3A)
ANP  A 202 (-4.1A)
ANP  A 202 (-4.6A)
 0.93A 6cduF-4q5hA:
undetectable
6cduJ-4q5hA:
undetectable		 6cduF-4q5hA:
18.04
6cduJ-4q5hA:
18.04