SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4q5n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE)
4q5n GLUTHATIONE
S-TRANSFERASE BLO T
8 ISOFORM

(Blomia
tropicalis)
4 / 7 TYR A   8
GLY A  13
ILE A 116
TYR A 120
None
None
GSH  A 402 ( 4.5A)
GSH  A 402 (-3.9A)
0.81A 11gsB-4q5nA:
25.7
11gsB-4q5nA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_A_ESTA1_1
(ESTROGEN RECEPTOR)
4q5n GLUTHATIONE
S-TRANSFERASE BLO T
8 ISOFORM

(Blomia
tropicalis)
5 / 10 MET A  90
GLU A 105
LEU A 171
HIS A  24
LEU A  21
None
1.35A 1a52A-4q5nA:
undetectable
1a52A-4q5nA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_B_ESTB2_1
(ESTROGEN RECEPTOR)
4q5n GLUTHATIONE
S-TRANSFERASE BLO T
8 ISOFORM

(Blomia
tropicalis)
5 / 10 MET A  90
GLU A 105
LEU A 171
HIS A  24
LEU A  21
None
1.33A 1a52B-4q5nA:
undetectable
1a52B-4q5nA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB6_0
(GRAMICIDIN A)
4q5n GLUTHATIONE
S-TRANSFERASE BLO T
8 ISOFORM

(Blomia
tropicalis)
3 / 3 TRP A   9
ALA A  15
VAL A  11
GSH  A 401 ( 4.9A)
None
None
0.94A 1bdwA-4q5nA:
undetectable
1bdwB-4q5nA:
undetectable
1bdwA-4q5nA:
8.47
1bdwB-4q5nA:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_A_ESTA600_1
(ESTROGEN RECEPTOR)
4q5n GLUTHATIONE
S-TRANSFERASE BLO T
8 ISOFORM

(Blomia
tropicalis)
5 / 9 MET A  90
GLU A 105
LEU A 171
HIS A  24
LEU A  21
None
1.31A 1ereA-4q5nA:
undetectable
1ereA-4q5nA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_B_ESTB600_1
(ESTROGEN RECEPTOR)
4q5n GLUTHATIONE
S-TRANSFERASE BLO T
8 ISOFORM

(Blomia
tropicalis)
5 / 9 MET A  90
GLU A 105
LEU A 171
HIS A  24
LEU A  21
None
1.32A 1ereB-4q5nA:
undetectable
1ereB-4q5nA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_C_ESTC600_1
(ESTROGEN RECEPTOR)
4q5n GLUTHATIONE
S-TRANSFERASE BLO T
8 ISOFORM

(Blomia
tropicalis)
5 / 9 MET A  90
GLU A 105
LEU A 171
HIS A  24
LEU A  21
None
1.32A 1ereC-4q5nA:
undetectable
1ereC-4q5nA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_D_ESTD600_1
(ESTROGEN RECEPTOR)
4q5n GLUTHATIONE
S-TRANSFERASE BLO T
8 ISOFORM

(Blomia
tropicalis)
5 / 9 MET A  90
GLU A 105
LEU A 171
HIS A  24
LEU A  21
None
1.32A 1ereD-4q5nA:
undetectable
1ereD-4q5nA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GWR_A_ESTA600_1
(OESTROGEN RECEPTOR)
4q5n GLUTHATIONE
S-TRANSFERASE BLO T
8 ISOFORM

(Blomia
tropicalis)
5 / 10 MET A  90
GLU A 105
LEU A 171
HIS A  24
LEU A  21
None
1.30A 1gwrA-4q5nA:
undetectable
1gwrA-4q5nA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GWR_B_ESTB600_1
(OESTROGEN RECEPTOR)
4q5n GLUTHATIONE
S-TRANSFERASE BLO T
8 ISOFORM

(Blomia
tropicalis)
5 / 9 MET A  90
GLU A 105
LEU A 171
HIS A  24
LEU A  21
None
1.32A 1gwrB-4q5nA:
undetectable
1gwrB-4q5nA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_A_AG2A7005_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)
4q5n GLUTHATIONE
S-TRANSFERASE BLO T
8 ISOFORM

(Blomia
tropicalis)
4 / 6 LEU A 171
LEU A  21
ILE A  80
GLU A 105
None
0.87A 1mt1A-4q5nA:
undetectable
1mt1F-4q5nA:
undetectable
1mt1A-4q5nA:
14.78
1mt1F-4q5nA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_B_AG2B7001_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)
4q5n GLUTHATIONE
S-TRANSFERASE BLO T
8 ISOFORM

(Blomia
tropicalis)
4 / 6 ILE A  80
GLU A 105
LEU A 171
LEU A  21
None
0.78A 1mt1B-4q5nA:
undetectable
1mt1C-4q5nA:
undetectable
1mt1B-4q5nA:
17.99
1mt1C-4q5nA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_L_AG2L7014_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)
4q5n GLUTHATIONE
S-TRANSFERASE BLO T
8 ISOFORM

(Blomia
tropicalis)
4 / 7 LEU A 171
LEU A  21
ILE A  80
GLU A 105
None
1.02A 1n13I-4q5nA:
undetectable
1n13L-4q5nA:
undetectable
1n13I-4q5nA:
14.78
1n13L-4q5nA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_B_ESTB2_1
(ESTROGEN RECEPTOR)
4q5n GLUTHATIONE
S-TRANSFERASE BLO T
8 ISOFORM

(Blomia
tropicalis)
5 / 10 MET A  90
GLU A 105
LEU A 171
HIS A  24
LEU A  21
None
1.34A 1pcgB-4q5nA:
undetectable
1pcgB-4q5nA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_L_ACTL611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)
4q5n GLUTHATIONE
S-TRANSFERASE BLO T
8 ISOFORM

(Blomia
tropicalis)
4 / 6 LEU A 115
TRP A 178
LEU A 223
PHE A  14
None
None
None
GSH  A 401 (-4.2A)
1.49A 1rukH-4q5nA:
undetectable
1rukL-4q5nA:
undetectable
1rukH-4q5nA:
20.16
1rukL-4q5nA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J7X_A_ESTA1454_1
(ESTROGEN RECEPTOR
BETA)
4q5n GLUTHATIONE
S-TRANSFERASE BLO T
8 ISOFORM

(Blomia
tropicalis)
5 / 12 MET A  90
GLU A 105
LEU A 171
HIS A  24
LEU A  21
None
1.27A 2j7xA-4q5nA:
undetectable
2j7xA-4q5nA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OCF_A_ESTA596_1
(ESTROGEN RECEPTOR)
4q5n GLUTHATIONE
S-TRANSFERASE BLO T
8 ISOFORM

(Blomia
tropicalis)
5 / 10 MET A  90
GLU A 105
LEU A 171
HIS A  24
LEU A  21
None
1.40A 2ocfA-4q5nA:
undetectable
2ocfA-4q5nA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWW_A_SFXA801_1
(TRANSPORTER)
4q5n GLUTHATIONE
S-TRANSFERASE BLO T
8 ISOFORM

(Blomia
tropicalis)
5 / 12 GLY A  13
LEU A 223
ARG A  12
TYR A 175
ASP A 177
None
1.03A 3gwwA-4q5nA:
undetectable
3gwwA-4q5nA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KM6_A_EAAA222_1
(GLUTATHIONE
S-TRANSFERASE P)
4q5n GLUTHATIONE
S-TRANSFERASE BLO T
8 ISOFORM

(Blomia
tropicalis)
5 / 10 TYR A   8
VAL A  11
GLY A  13
TRP A  50
ILE A 116
None
None
None
GSH  A 401 (-4.0A)
GSH  A 402 ( 4.5A)
0.98A 3km6A-4q5nA:
25.4
3km6A-4q5nA:
26.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_B_EAAB214_1
(GLUTATHIONE
S-TRANSFERASE P)
4q5n GLUTHATIONE
S-TRANSFERASE BLO T
8 ISOFORM

(Blomia
tropicalis)
4 / 8 TYR A   8
VAL A  11
GLY A  13
ILE A 116
None
None
None
GSH  A 402 ( 4.5A)
0.67A 3n9jB-4q5nA:
25.6
3n9jB-4q5nA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)
4q5n GLUTHATIONE
S-TRANSFERASE BLO T
8 ISOFORM

(Blomia
tropicalis)
5 / 12 MET A  90
GLU A 105
LEU A 171
HIS A  24
LEU A  21
None
1.25A 3olsB-4q5nA:
undetectable
3olsB-4q5nA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UUD_B_ESTB600_1
(ESTROGEN RECEPTOR)
4q5n GLUTHATIONE
S-TRANSFERASE BLO T
8 ISOFORM

(Blomia
tropicalis)
5 / 10 MET A  90
GLU A 105
LEU A 171
HIS A  24
LEU A  21
None
1.35A 3uudB-4q5nA:
undetectable
3uudB-4q5nA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ASCA904_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)
4q5n GLUTHATIONE
S-TRANSFERASE BLO T
8 ISOFORM

(Blomia
tropicalis)
4 / 6 PHE A  14
PRO A  65
GLU A  76
SER A  77
GSH  A 401 (-4.2A)
GSH  A 401 ( 4.8A)
GSH  A 401 (-2.9A)
GSH  A 401 (-2.9A)
0.51A 3vlnA-4q5nA:
18.8
3vlnA-4q5nA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DMG_A_SAMA401_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA1493)
4q5n GLUTHATIONE
S-TRANSFERASE BLO T
8 ISOFORM

(Blomia
tropicalis)
5 / 12 ARG A 180
TYR A 175
ASP A 169
GLU A 105
PRO A  17
None
1.40A 4dmgA-4q5nA:
undetectable
4dmgA-4q5nA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DMG_B_SAMB401_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA1493)
4q5n GLUTHATIONE
S-TRANSFERASE BLO T
8 ISOFORM

(Blomia
tropicalis)
5 / 11 ARG A 180
TYR A 175
ASP A 169
GLU A 105
PRO A  17
None
1.39A 4dmgB-4q5nA:
2.1
4dmgB-4q5nA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_C_ESTC600_1
(ESTROGEN RECEPTOR
BETA)
4q5n GLUTHATIONE
S-TRANSFERASE BLO T
8 ISOFORM

(Blomia
tropicalis)
5 / 12 MET A  90
GLU A 105
LEU A 171
HIS A  24
LEU A  21
None
1.27A 4j24C-4q5nA:
undetectable
4j24C-4q5nA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)
4q5n GLUTHATIONE
S-TRANSFERASE BLO T
8 ISOFORM

(Blomia
tropicalis)
5 / 12 MET A  90
GLU A 105
LEU A 171
HIS A  24
LEU A  21
None
1.29A 4j26A-4q5nA:
undetectable
4j26A-4q5nA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)
4q5n GLUTHATIONE
S-TRANSFERASE BLO T
8 ISOFORM

(Blomia
tropicalis)
5 / 12 MET A  90
GLU A 105
LEU A 171
HIS A  24
LEU A  21
None
1.30A 4j26B-4q5nA:
undetectable
4j26B-4q5nA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DX3_A_ESTA601_1
(ESTROGEN RECEPTOR)
4q5n GLUTHATIONE
S-TRANSFERASE BLO T
8 ISOFORM

(Blomia
tropicalis)
5 / 10 MET A  90
GLU A 105
LEU A 171
HIS A  24
LEU A  21
None
1.38A 5dx3A-4q5nA:
undetectable
5dx3A-4q5nA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DX3_B_ESTB1000_1
(ESTROGEN RECEPTOR)
4q5n GLUTHATIONE
S-TRANSFERASE BLO T
8 ISOFORM

(Blomia
tropicalis)
5 / 9 MET A  90
GLU A 105
LEU A 171
HIS A  24
LEU A  21
None
1.35A 5dx3B-4q5nA:
undetectable
5dx3B-4q5nA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_A_ESTA1000_1
(ESTROGEN RECEPTOR)
4q5n GLUTHATIONE
S-TRANSFERASE BLO T
8 ISOFORM

(Blomia
tropicalis)
5 / 10 MET A  90
GLU A 105
LEU A 171
HIS A  24
LEU A  21
None
1.40A 5dxbA-4q5nA:
undetectable
5dxbA-4q5nA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_B_ESTB1000_1
(ESTROGEN RECEPTOR)
4q5n GLUTHATIONE
S-TRANSFERASE BLO T
8 ISOFORM

(Blomia
tropicalis)
5 / 10 MET A  90
GLU A 105
LEU A 171
HIS A  24
LEU A  21
None
1.37A 5dxeB-4q5nA:
undetectable
5dxeB-4q5nA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXG_A_ESTA1000_1
(ESTROGEN RECEPTOR)
4q5n GLUTHATIONE
S-TRANSFERASE BLO T
8 ISOFORM

(Blomia
tropicalis)
5 / 9 MET A  90
GLU A 105
LEU A 171
HIS A  24
LEU A  21
None
1.37A 5dxgA-4q5nA:
undetectable
5dxgA-4q5nA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HYR_A_ESTA601_1
(ESTROGEN RECEPTOR)
4q5n GLUTHATIONE
S-TRANSFERASE BLO T
8 ISOFORM

(Blomia
tropicalis)
5 / 10 MET A  90
GLU A 105
LEU A 171
HIS A  24
LEU A  21
None
1.41A 5hyrA-4q5nA:
undetectable
5hyrA-4q5nA:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HYR_B_ESTB601_1
(ESTROGEN RECEPTOR)
4q5n GLUTHATIONE
S-TRANSFERASE BLO T
8 ISOFORM

(Blomia
tropicalis)
5 / 11 MET A  90
GLU A 105
LEU A 171
HIS A  24
LEU A  21
None
1.40A 5hyrB-4q5nA:
undetectable
5hyrB-4q5nA:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WGD_A_ESTA601_1
(ESTROGEN RECEPTOR)
4q5n GLUTHATIONE
S-TRANSFERASE BLO T
8 ISOFORM

(Blomia
tropicalis)
5 / 9 MET A  90
GLU A 105
LEU A 171
HIS A  24
LEU A  21
None
1.35A 5wgdA-4q5nA:
undetectable
5wgdA-4q5nA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WGQ_B_ESTB601_1
(ESTROGEN RECEPTOR)
4q5n GLUTHATIONE
S-TRANSFERASE BLO T
8 ISOFORM

(Blomia
tropicalis)
5 / 10 MET A  90
GLU A 105
LEU A 171
HIS A  24
LEU A  21
None
1.34A 5wgqB-4q5nA:
undetectable
5wgqB-4q5nA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_B_ESTB602_1
(ESTROGEN RECEPTOR)
4q5n GLUTHATIONE
S-TRANSFERASE BLO T
8 ISOFORM

(Blomia
tropicalis)
5 / 10 MET A  90
GLU A 105
LEU A 171
HIS A  24
LEU A  21
None
1.39A 6cbzB-4q5nA:
undetectable
6cbzB-4q5nA:
15.55