SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4q5r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZB7_A_NCAA901_0
(PROSTAGLANDIN
REDUCTASE 2)		 4q5r GLUTATHIONE
S-TRANSFERASE
(Blattella
germanica) 		4 / 5 TYR A 156
ILE A  96
LEU A 161
LEU A 164
 None
 1.05A 2zb7A-4q5rA:
undetectable		 2zb7A-4q5rA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4q5r GLUTATHIONE
S-TRANSFERASE
(Blattella
germanica) 		5 / 12 LEU A 189
ALA A 191
ILE A 192
ILE A  19
PHE A 155
 None
 1.07A 3b2rA-4q5rA:
undetectable		 3b2rA-4q5rA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4q5r GLUTATHIONE
S-TRANSFERASE
(Blattella
germanica) 		5 / 11 LEU A 189
ALA A 191
ILE A 192
ILE A  19
PHE A 155
 None
 1.06A 3b2rB-4q5rA:
undetectable		 3b2rB-4q5rA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D9L_A_ACTA501_0
(CTD-PEPTIDE
RNA-BINDING PROTEIN
16)		 4q5r GLUTATHIONE
S-TRANSFERASE
(Blattella
germanica) 		4 / 5 PRO A  18
ILE A  19
PRO A  53
TYR A   9
 None
None
GSH  A 301 (-4.3A)
None
 1.14A 3d9lA-4q5rA:
undetectable
3d9lY-4q5rA:
undetectable		 3d9lA-4q5rA:
22.33
3d9lY-4q5rA:
2.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_C_LEIC16_0
(COIL SER L16D-PEN)		 4q5r GLUTATHIONE
S-TRANSFERASE
(Blattella
germanica) 		4 / 6 LYS A  28
LEU A  23
GLN A  75
LEU A  22
 None
 1.13A 3h5gB-4q5rA:
undetectable
3h5gC-4q5rA:
undetectable		 3h5gB-4q5rA:
10.05
3h5gC-4q5rA:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA303_1
(CHITOSANASE)		 4q5r GLUTATHIONE
S-TRANSFERASE
(Blattella
germanica) 		4 / 6 ILE A  89
ASP A  90
ARG A  70
GLY A  73
 None
 0.72A 4oltA-4q5rA:
undetectable		 4oltA-4q5rA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB303_1
(CHITOSANASE)		 4q5r GLUTATHIONE
S-TRANSFERASE
(Blattella
germanica) 		4 / 6 ILE A  89
ASP A  90
ARG A  70
GLY A  73
 None
 0.77A 4oltB-4q5rA:
1.0		 4oltB-4q5rA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA301_1
(CHITOSANASE)		 4q5r GLUTATHIONE
S-TRANSFERASE
(Blattella
germanica) 		4 / 8 ILE A  89
ASP A  90
ARG A  70
GLY A  73
 None
 0.78A 5hwaA-4q5rA:
undetectable		 5hwaA-4q5rA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CK2_C_IPHC101_0
(INSULIN A CHAIN
INSULIN B CHAIN)		 4q5r GLUTATHIONE
S-TRANSFERASE
(Blattella
germanica) 		4 / 4 ILE A 160
LEU A 172
HIS A 166
ALA A 168
 None
 0.97A 6ck2C-4q5rA:
undetectable
6ck2D-4q5rA:
undetectable		 6ck2C-4q5rA:
14.29
6ck2D-4q5rA:
6.44