SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4q5t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		 4q5t LIPOPROTEIN
(Streptococcus
mutans) 		5 / 9 GLU A 132
LEU A 221
ALA A 158
LEU A 116
LEU A 160
 None
 1.46A 1hwiA-4q5tA:
undetectable		 1hwiA-4q5tA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_0
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 4q5t LIPOPROTEIN
(Streptococcus
mutans) 		5 / 12 LEU A 155
ALA A 158
SER A 220
TYR A 127
ILE A 133
 None
 1.25A 1kglA-4q5tA:
undetectable		 1kglA-4q5tA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 4q5t LIPOPROTEIN
(Streptococcus
mutans) 		3 / 3 ASN A 147
ARG A 150
ASP A 276
 None
 0.97A 2qe6A-4q5tA:
undetectable		 2qe6A-4q5tA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 4q5t LIPOPROTEIN
(Streptococcus
mutans) 		3 / 3 ASN A 147
ARG A 150
ASP A 276
 None
 0.99A 2qe6B-4q5tA:
undetectable		 2qe6B-4q5tA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_A_CGEA501_1
(CYTOCHROME P450 2B4)		 4q5t LIPOPROTEIN
(Streptococcus
mutans) 		5 / 10 VAL A 188
ALA A 198
THR A 120
ILE A 215
VAL A 205
 None
 1.08A 3me6A-4q5tA:
undetectable		 3me6A-4q5tA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_1
(HIV-1 PROTEASE)		 4q5t LIPOPROTEIN
(Streptococcus
mutans) 		5 / 9 LEU A 197
ALA A 140
GLY A 137
ILE A 133
THR A 120
 None
 1.22A 3spkA-4q5tA:
undetectable		 3spkA-4q5tA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4q5t LIPOPROTEIN
(Streptococcus
mutans) 		4 / 8 ASN A 235
GLU A 108
ILE A 236
ASN A  90
 None
 1.00A 4d33A-4q5tA:
undetectable		 4d33A-4q5tA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4q5t LIPOPROTEIN
(Streptococcus
mutans) 		4 / 7 ASN A 235
GLU A 108
ILE A 236
ASN A  90
 None
 0.99A 4d33B-4q5tA:
undetectable		 4d33B-4q5tA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4q5t LIPOPROTEIN
(Streptococcus
mutans) 		4 / 8 ASN A 235
GLU A 108
ILE A 236
ASN A  90
 None
 1.02A 4d39A-4q5tA:
undetectable		 4d39A-4q5tA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4q5t LIPOPROTEIN
(Streptococcus
mutans) 		4 / 7 ASN A 235
GLU A 108
ILE A 236
ASN A  90
 None
 0.92A 4d39B-4q5tA:
undetectable		 4d39B-4q5tA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_A_SALA801_1
(PROTEIN POLYBROMO-1)		 4q5t LIPOPROTEIN
(Streptococcus
mutans) 		4 / 7 ILE A  83
LEU A  61
ALA A 251
ILE A 252
 None
 0.76A 4y03A-4q5tA:
undetectable		 4y03A-4q5tA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUJ_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 4q5t LIPOPROTEIN
(Streptococcus
mutans) 		4 / 8 VAL A  34
LEU A  32
ILE A 256
VAL A 106
 None
 0.81A 5nujA-4q5tA:
undetectable		 5nujA-4q5tA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F32_B_ACTB602_0
(AMINE OXIDASE LKCE)		 4q5t LIPOPROTEIN
(Streptococcus
mutans) 		4 / 6 ASN A  93
TYR A  89
VAL A 104
THR A 105
 None
 1.20A 6f32B-4q5tA:
undetectable		 6f32B-4q5tA:
19.14