SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4q5w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_2
(TRANSTHYRETIN)		 4q5w MATERNAL PROTEIN
TUDOR
(Drosophila
melanogaster) 		4 / 8 GLU A2000
THR A1981
ALA A1983
VAL A2119
 EPE  A2201 (-3.5A)
EPE  A2201 (-2.8A)
None
None
 0.68A 1sn5C-4q5wA:
undetectable		 1sn5C-4q5wA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_B_DESB128_1
(TRANSTHYRETIN)		 4q5w MATERNAL PROTEIN
TUDOR
(Drosophila
melanogaster) 		5 / 11 LEU A2150
LEU A2147
ALA A2108
LEU A2110
THR A2105
 None
 1.12A 1tz8A-4q5wA:
undetectable
1tz8B-4q5wA:
undetectable		 1tz8A-4q5wA:
24.32
1tz8B-4q5wA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4q5w MATERNAL PROTEIN
TUDOR
(Drosophila
melanogaster) 		4 / 6 LEU A2150
ARG A2132
THR A2134
LEU A2141
 None
 1.06A 2eijA-4q5wA:
undetectable
2eijJ-4q5wA:
undetectable		 2eijA-4q5wA:
14.40
2eijJ-4q5wA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4q5w MATERNAL PROTEIN
TUDOR
(Drosophila
melanogaster) 		4 / 6 LEU A2150
ARG A2132
THR A2134
LEU A2141
 None
 1.05A 2eilA-4q5wA:
undetectable
2eilJ-4q5wA:
undetectable		 2eilA-4q5wA:
14.40
2eilJ-4q5wA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_2
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT
LIGHT CHAIN OF
ANTIBODY FAB
FRAGMENT)		 4q5w MATERNAL PROTEIN
TUDOR
(Drosophila
melanogaster) 		4 / 5 TYR A2071
GLN A2033
LEU A2038
PHE A2040
 None
 1.19A 3ls4L-4q5wA:
undetectable		 3ls4L-4q5wA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 4q5w MATERNAL PROTEIN
TUDOR
(Drosophila
melanogaster) 		4 / 6 PHE A2121
CYH A2087
VAL A2117
PHE A1998
 EPE  A2201 (-4.4A)
None
None
EPE  A2201 (-3.3A)
 1.27A 3ltwA-4q5wA:
undetectable		 3ltwA-4q5wA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OI8_A_ADNA2_1
(UNCHARACTERIZED
PROTEIN)		 4q5w MATERNAL PROTEIN
TUDOR
(Drosophila
melanogaster) 		4 / 6 ILE A2008
PRO A2074
LEU A2012
ASP A2060
 None
 1.24A 3oi8A-4q5wA:
undetectable		 3oi8A-4q5wA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDZ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4q5w MATERNAL PROTEIN
TUDOR
(Drosophila
melanogaster) 		4 / 7 ILE A2086
GLY A2062
THR A2064
LEU A2046
 None
 0.94A 4zdzA-4q5wA:
undetectable		 4zdzA-4q5wA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE3_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4q5w MATERNAL PROTEIN
TUDOR
(Drosophila
melanogaster) 		4 / 7 ILE A2086
GLY A2062
THR A2064
LEU A2046
 None
 0.90A 4ze3A-4q5wA:
undetectable		 4ze3A-4q5wA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4q5w MATERNAL PROTEIN
TUDOR
(Drosophila
melanogaster) 		4 / 7 LEU A2150
ARG A2132
THR A2134
LEU A2141
 None
 0.88A 5xdqA-4q5wA:
undetectable
5xdqJ-4q5wA:
undetectable		 5xdqA-4q5wA:
14.40
5xdqJ-4q5wA:
16.39