SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4q5y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_A_SALA710_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 4q5y MATERNAL PROTEIN
TUDOR
(Drosophila
melanogaster) 		4 / 7 VAL A2180
LEU A2272
ALA A2320
LEU A2322
 None
 0.83A 1pthA-4q5yA:
undetectable		 1pthA-4q5yA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_B_SALB711_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 4q5y MATERNAL PROTEIN
TUDOR
(Drosophila
melanogaster) 		4 / 7 VAL A2180
LEU A2272
ALA A2320
LEU A2322
 None
 0.83A 1pthB-4q5yA:
undetectable		 1pthB-4q5yA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_B_SNLB2001_1
(MINERALOCORTICOID
RECEPTOR)		 4q5y MATERNAL PROTEIN
TUDOR
(Drosophila
melanogaster) 		5 / 12 LEU A2398
ALA A2397
CYH A2423
THR A2436
PHE A2439
 None
 1.15A 2oaxB-4q5yA:
undetectable		 2oaxB-4q5yA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_1
(MINERALOCORTICOID
RECEPTOR)		 4q5y MATERNAL PROTEIN
TUDOR
(Drosophila
melanogaster) 		5 / 12 LEU A2398
ALA A2397
CYH A2423
THR A2436
PHE A2439
 None
 1.23A 2oaxF-4q5yA:
undetectable		 2oaxF-4q5yA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z97_A_CAMA422_0
(CYTOCHROME P450-CAM)		 4q5y MATERNAL PROTEIN
TUDOR
(Drosophila
melanogaster) 		4 / 6 LEU A2458
VAL A2498
VAL A2353
VAL A2364
 None
 0.94A 2z97A-4q5yA:
undetectable		 2z97A-4q5yA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4q5y MATERNAL PROTEIN
TUDOR
(Drosophila
melanogaster) 		4 / 7 ILE A2428
MET A2376
THR A2377
LEU A2380
 None
 1.02A 3ablA-4q5yA:
undetectable
3ablJ-4q5yA:
undetectable		 3ablA-4q5yA:
20.42
3ablJ-4q5yA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 4q5y MATERNAL PROTEIN
TUDOR
(Drosophila
melanogaster) 		4 / 5 TYR A2452
MET A2376
THR A2377
LEU A2380
 None
 1.22A 3ag1J-4q5yA:
undetectable		 3ag1J-4q5yA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_G_TFPG201_1
(PROTEIN S100-A4)		 4q5y MATERNAL PROTEIN
TUDOR
(Drosophila
melanogaster) 		5 / 9 GLY A2172
PHE A2292
GLY A2249
ILE A2168
PHE A2329
 None
 1.46A 3ko0F-4q5yA:
undetectable
3ko0G-4q5yA:
undetectable		 3ko0F-4q5yA:
20.08
3ko0G-4q5yA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4q5y MATERNAL PROTEIN
TUDOR
(Drosophila
melanogaster) 		4 / 6 ILE A2428
MET A2376
THR A2377
LEU A2380
 None
 1.02A 3wg7N-4q5yA:
undetectable
3wg7W-4q5yA:
undetectable		 3wg7N-4q5yA:
20.42
3wg7W-4q5yA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4q5y MATERNAL PROTEIN
TUDOR
(Drosophila
melanogaster) 		4 / 7 ILE A2428
MET A2376
THR A2377
LEU A2380
 None
 0.96A 5b1bA-4q5yA:
undetectable
5b1bJ-4q5yA:
undetectable		 5b1bA-4q5yA:
20.42
5b1bJ-4q5yA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4q5y MATERNAL PROTEIN
TUDOR
(Drosophila
melanogaster) 		4 / 7 ILE A2428
MET A2376
THR A2377
LEU A2380
 None
 0.99A 5iy5A-4q5yA:
undetectable
5iy5J-4q5yA:
undetectable		 5iy5A-4q5yA:
20.42
5iy5J-4q5yA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_2
(CYTOCHROME P450 3A5)		 4q5y MATERNAL PROTEIN
TUDOR
(Drosophila
melanogaster) 		4 / 5 ARG A2478
PHE A2501
PHE A2483
LEU A2500
 None
 1.31A 5veuH-4q5yA:
undetectable		 5veuH-4q5yA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_J_CHDJ101_1
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4q5y MATERNAL PROTEIN
TUDOR
(Drosophila
melanogaster) 		4 / 5 TYR A2452
MET A2376
THR A2377
LEU A2380
 None
 1.16A 5w97J-4q5yA:
undetectable		 5w97J-4q5yA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4q5y MATERNAL PROTEIN
TUDOR
(Drosophila
melanogaster) 		4 / 5 TYR A2452
MET A2376
THR A2377
LEU A2380
 None
 1.21A 5x19J-4q5yA:
undetectable		 5x19J-4q5yA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4q5y MATERNAL PROTEIN
TUDOR
(Drosophila
melanogaster) 		4 / 5 TYR A2452
MET A2376
THR A2377
LEU A2380
 None
 1.22A 5x1bJ-4q5yA:
undetectable		 5x1bJ-4q5yA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4q5y MATERNAL PROTEIN
TUDOR
(Drosophila
melanogaster) 		4 / 5 TYR A2452
MET A2376
THR A2377
LEU A2380
 None
 1.17A 5x1bW-4q5yA:
undetectable		 5x1bW-4q5yA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4q5y MATERNAL PROTEIN
TUDOR
(Drosophila
melanogaster) 		4 / 5 TYR A2452
MET A2376
THR A2377
LEU A2380
 None
 1.20A 5x1fW-4q5yA:
undetectable		 5x1fW-4q5yA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4q5y MATERNAL PROTEIN
TUDOR
(Drosophila
melanogaster) 		4 / 6 ILE A2428
MET A2376
THR A2377
LEU A2380
 None
 1.01A 5z86N-4q5yA:
undetectable
5z86W-4q5yA:
undetectable		 5z86N-4q5yA:
20.42
5z86W-4q5yA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4q5y MATERNAL PROTEIN
TUDOR
(Drosophila
melanogaster) 		4 / 6 ILE A2428
MET A2376
THR A2377
LEU A2380
 None
 1.02A 5zcoN-4q5yA:
undetectable
5zcoW-4q5yA:
undetectable		 5zcoN-4q5yA:
20.42
5zcoW-4q5yA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_BEZA401_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 4q5y MATERNAL PROTEIN
TUDOR
(Drosophila
melanogaster) 		5 / 9 LEU A2458
THR A2462
ILE A2507
ARG A2499
PHE A2501
 None
 1.21A 6ef6A-4q5yA:
undetectable		 6ef6A-4q5yA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ102_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4q5y MATERNAL PROTEIN
TUDOR
(Drosophila
melanogaster) 		4 / 5 TYR A2452
MET A2376
THR A2377
LEU A2380
 None
 1.18A 6nknJ-4q5yA:
undetectable		 6nknJ-4q5yA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW102_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4q5y MATERNAL PROTEIN
TUDOR
(Drosophila
melanogaster) 		4 / 5 TYR A2452
MET A2376
THR A2377
LEU A2380
 None
 1.19A 6nknW-4q5yA:
undetectable		 6nknW-4q5yA:
9.57