SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4q60'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ILP_C_ACAC7_1
(PROTEIN
(INTERLEUKIN-8
PRECURSOR)
PROTEIN
(INTERLEUKIN-8
RECEPTOR))		 4q60 PROLINE RACEMASE
(Burkholderia
multivorans) 		4 / 5 LYS A 234
PRO A 236
HIS A 209
ASP A 208
 None
 1.42A 1ilpA-4q60A:
0.3
1ilpC-4q60A:
undetectable		 1ilpA-4q60A:
11.73
1ilpC-4q60A:
3.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_D_RBFD504_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4q60 PROLINE RACEMASE
(Burkholderia
multivorans) 		5 / 12 ILE A 299
LEU A 297
GLY A  23
SER A  22
ILE A   7
 None
 1.27A 1kyvC-4q60A:
undetectable
1kyvD-4q60A:
undetectable		 1kyvC-4q60A:
18.81
1kyvD-4q60A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_E_RBFE505_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4q60 PROLINE RACEMASE
(Burkholderia
multivorans) 		5 / 12 ILE A 299
LEU A 297
GLY A  23
SER A  22
ILE A   7
 None
 1.26A 1kyvD-4q60A:
undetectable
1kyvE-4q60A:
undetectable		 1kyvD-4q60A:
18.81
1kyvE-4q60A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_0
(MODIFICATION
METHYLASE RSRI)		 4q60 PROLINE RACEMASE
(Burkholderia
multivorans) 		5 / 12 ASP A   9
THR A 239
GLY A  13
SER A 268
ALA A 289
 GOL  A 401 ( 4.6A)
PYC  A 402 (-3.4A)
None
None
None
 1.32A 1nw5A-4q60A:
undetectable		 1nw5A-4q60A:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_C_DEXC3999_1
(GLUCOCORTICOID
RECEPTOR)		 4q60 PROLINE RACEMASE
(Burkholderia
multivorans) 		5 / 12 ASN A 134
GLY A 161
LEU A  86
CYH A  89
THR A  93
 PYC  A 402 (-4.2A)
None
None
None
None
 1.50A 1p93C-4q60A:
undetectable		 1p93C-4q60A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X1A_A_SAMA4264_0
(CRTF-RELATED PROTEIN)		 4q60 PROLINE RACEMASE
(Burkholderia
multivorans) 		5 / 12 HIS A  91
ALA A 289
GLY A  62
LEU A  86
ILE A  51
 None
 1.06A 1x1aA-4q60A:
undetectable		 1x1aA-4q60A:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_C_TPFC2471_1
(CYTOCHROME P450 121)		 4q60 PROLINE RACEMASE
(Burkholderia
multivorans) 		4 / 8 VAL A 225
ASN A 163
ALA A 243
GLN A 262
 None
 1.18A 2ij7C-4q60A:
undetectable		 2ij7C-4q60A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		 4q60 PROLINE RACEMASE
(Burkholderia
multivorans) 		3 / 3 SER A 129
THR A  12
PHE A  79
 None
 0.74A 2x91A-4q60A:
undetectable		 2x91A-4q60A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4q60 PROLINE RACEMASE
(Burkholderia
multivorans) 		4 / 5 PRO A  16
VAL A  61
THR A 241
GLY A 240
 None
None
PYC  A 402 (-3.6A)
PYC  A 402 (-4.0A)
 1.21A 3elzB-4q60A:
undetectable		 3elzB-4q60A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_A_DEXA247_1
(GLUCOCORTICOID
RECEPTOR 2)		 4q60 PROLINE RACEMASE
(Burkholderia
multivorans) 		5 / 12 ASN A 134
GLY A 161
CYH A  89
THR A  93
VAL A 132
 PYC  A 402 (-4.2A)
None
None
None
None
 1.29A 3gn8A-4q60A:
undetectable		 3gn8A-4q60A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_B_DEXB247_1
(GLUCOCORTICOID
RECEPTOR 2)		 4q60 PROLINE RACEMASE
(Burkholderia
multivorans) 		5 / 12 ASN A 134
GLY A 161
CYH A  89
THR A  93
VAL A 132
 PYC  A 402 (-4.2A)
None
None
None
None
 1.31A 3gn8B-4q60A:
undetectable		 3gn8B-4q60A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_Q_TFPQ201_1
(PROTEIN S100-A4)		 4q60 PROLINE RACEMASE
(Burkholderia
multivorans) 		4 / 8 GLY A  23
PHE A  24
ILE A   8
PHE A  80
 None
 0.88A 3ko0O-4q60A:
undetectable
3ko0Q-4q60A:
undetectable		 3ko0O-4q60A:
13.55
3ko0Q-4q60A:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_A_ACTA603_0
(CHOLINE OXIDASE)		 4q60 PROLINE RACEMASE
(Burkholderia
multivorans) 		3 / 3 ARG A 286
HIS A 271
SER A 131
 None
 0.95A 4mjwA-4q60A:
undetectable
4mjwB-4q60A:
undetectable		 4mjwA-4q60A:
21.31
4mjwB-4q60A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_B_ACTB603_0
(CHOLINE OXIDASE)		 4q60 PROLINE RACEMASE
(Burkholderia
multivorans) 		3 / 3 SER A 131
ARG A 286
HIS A 271
 None
 0.96A 4mjwA-4q60A:
undetectable
4mjwB-4q60A:
undetectable		 4mjwA-4q60A:
21.31
4mjwB-4q60A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_2
(TUBULIN BETA CHAIN)		 4q60 PROLINE RACEMASE
(Burkholderia
multivorans) 		5 / 12 CYH A 247
LEU A 248
LEU A 167
ALA A 137
ALA A 159
 None
 1.09A 4x1kD-4q60A:
undetectable		 4x1kD-4q60A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_B_AG2B501_1
(ARGININE/AGMATINE
ANTIPORTER)		 4q60 PROLINE RACEMASE
(Burkholderia
multivorans) 		4 / 6 ILE A  94
GLY A 161
ASN A 163
ILE A 285
 None
None
None
PYC  A 402 (-3.8A)
 0.90A 5j4nB-4q60A:
undetectable		 5j4nB-4q60A:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4q60 PROLINE RACEMASE
(Burkholderia
multivorans) 		5 / 12 ALA A  74
VAL A  97
GLY A  95
SER A  10
LEU A 291
 None
 1.09A 5kirA-4q60A:
undetectable		 5kirA-4q60A:
17.99