SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4q62'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		 4q62 LEUCINE-RICH
REPEAT-AND COILED
COIL-CONTAINING
PROTEIN
(Legionella
pneumophila) 		4 / 8 SER A  90
SER A  64
ASP A  38
LYS A   7
 None
 1.24A 1hwiB-4q62A:
undetectable		 1hwiB-4q62A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZ4_A_BEZA784_0
(MALT REGULATORY
PROTEIN)		 4q62 LEUCINE-RICH
REPEAT-AND COILED
COIL-CONTAINING
PROTEIN
(Legionella
pneumophila) 		4 / 6 HIS A 181
LEU A 185
LEU A 207
PRO A 206
 None
 1.23A 1hz4A-4q62A:
undetectable		 1hz4A-4q62A:
24.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_B_CHDB1130_0
(FATTY ACID-BINDING
PROTEIN)		 4q62 LEUCINE-RICH
REPEAT-AND COILED
COIL-CONTAINING
PROTEIN
(Legionella
pneumophila) 		5 / 12 LEU A  83
LEU A  80
LEU A  52
ILE A  62
LEU A 106
 None
 1.28A 1tw4B-4q62A:
undetectable		 1tw4B-4q62A:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_C_CHDC3271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 4q62 LEUCINE-RICH
REPEAT-AND COILED
COIL-CONTAINING
PROTEIN
(Legionella
pneumophila) 		5 / 8 LYS A 159
LEU A 161
PHE A 179
PHE A 164
LEU A 136
 None
 1.47A 1v54C-4q62A:
undetectable
1v54J-4q62A:
undetectable		 1v54C-4q62A:
18.18
1v54J-4q62A:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_P_CHDP4271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 4q62 LEUCINE-RICH
REPEAT-AND COILED
COIL-CONTAINING
PROTEIN
(Legionella
pneumophila) 		5 / 8 LYS A 159
LEU A 161
PHE A 179
PHE A 164
LEU A 136
 None
 1.45A 1v54P-4q62A:
undetectable
1v54W-4q62A:
undetectable		 1v54P-4q62A:
18.18
1v54W-4q62A:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_D_NCAD510_0
(NAD-DEPENDENT
DEACETYLASE 2)		 4q62 LEUCINE-RICH
REPEAT-AND COILED
COIL-CONTAINING
PROTEIN
(Legionella
pneumophila) 		4 / 5 ALA A  22
PHE A  19
ASN A  28
ILE A  59
 None
 1.17A 1yc2D-4q62A:
undetectable		 1yc2D-4q62A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_D_H4BD1290_1
(PTERIDINE REDUCTASE
1)		 4q62 LEUCINE-RICH
REPEAT-AND COILED
COIL-CONTAINING
PROTEIN
(Legionella
pneumophila) 		4 / 8 PHE A  44
LEU A  67
LEU A  56
LEU A  23
 None
 0.87A 2bfpD-4q62A:
undetectable		 2bfpD-4q62A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4q62 LEUCINE-RICH
REPEAT-AND COILED
COIL-CONTAINING
PROTEIN
(Legionella
pneumophila) 		3 / 3 LYS A  92
ASP A 189
ASP A 237
 None
 1.00A 2br4A-4q62A:
undetectable		 2br4A-4q62A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4q62 LEUCINE-RICH
REPEAT-AND COILED
COIL-CONTAINING
PROTEIN
(Legionella
pneumophila) 		5 / 8 LYS A 159
LEU A 161
PHE A 179
PHE A 164
LEU A 136
 None
 1.45A 2dyrP-4q62A:
undetectable
2dyrW-4q62A:
undetectable		 2dyrP-4q62A:
18.18
2dyrW-4q62A:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4q62 LEUCINE-RICH
REPEAT-AND COILED
COIL-CONTAINING
PROTEIN
(Legionella
pneumophila) 		5 / 8 LYS A 159
LEU A 161
PHE A 179
PHE A 164
LEU A 136
 None
 1.47A 2eikP-4q62A:
undetectable
2eikW-4q62A:
undetectable		 2eikP-4q62A:
18.18
2eikW-4q62A:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_W_CHDW1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4q62 LEUCINE-RICH
REPEAT-AND COILED
COIL-CONTAINING
PROTEIN
(Legionella
pneumophila) 		5 / 7 LYS A 159
LEU A 161
PHE A 179
PHE A 164
LEU A 136
 None
 1.49A 2eimP-4q62A:
undetectable
2eimW-4q62A:
undetectable		 2eimP-4q62A:
18.18
2eimW-4q62A:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_B_VD3B2001_1
(VITAMIN D
HYDROXYLASE)		 4q62 LEUCINE-RICH
REPEAT-AND COILED
COIL-CONTAINING
PROTEIN
(Legionella
pneumophila) 		5 / 11 LEU A 264
ASN A 241
LEU A 276
ILE A 277
THR A 301
 None
None
SO4  A 504 (-4.7A)
None
None
 1.41A 3a50B-4q62A:
undetectable		 3a50B-4q62A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_P_CHDP1271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 4q62 LEUCINE-RICH
REPEAT-AND COILED
COIL-CONTAINING
PROTEIN
(Legionella
pneumophila) 		5 / 7 LYS A 159
LEU A 161
PHE A 179
PHE A 164
LEU A 136
 None
 1.44A 3asnP-4q62A:
undetectable
3asnW-4q62A:
undetectable		 3asnP-4q62A:
18.18
3asnW-4q62A:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_P_CHDP1271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 4q62 LEUCINE-RICH
REPEAT-AND COILED
COIL-CONTAINING
PROTEIN
(Legionella
pneumophila) 		5 / 7 LYS A 159
LEU A 161
PHE A 179
PHE A 164
LEU A 136
 None
 1.44A 3asoP-4q62A:
undetectable
3asoW-4q62A:
undetectable		 3asoP-4q62A:
18.18
3asoW-4q62A:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_A_AICA375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 4q62 LEUCINE-RICH
REPEAT-AND COILED
COIL-CONTAINING
PROTEIN
(Legionella
pneumophila) 		5 / 11 THR A 371
LEU A 368
ASN A 396
LEU A 311
LEU A 318
 None
 1.32A 3ndvA-4q62A:
undetectable
3ndvB-4q62A:
undetectable		 3ndvA-4q62A:
19.86
3ndvB-4q62A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_B_AICB376_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 4q62 LEUCINE-RICH
REPEAT-AND COILED
COIL-CONTAINING
PROTEIN
(Legionella
pneumophila) 		5 / 11 LEU A 318
THR A 371
LEU A 368
ASN A 396
LEU A 311
 None
 1.32A 3ndvA-4q62A:
undetectable
3ndvB-4q62A:
undetectable		 3ndvA-4q62A:
19.86
3ndvB-4q62A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_C_AICC375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 4q62 LEUCINE-RICH
REPEAT-AND COILED
COIL-CONTAINING
PROTEIN
(Legionella
pneumophila) 		5 / 11 THR A 371
LEU A 368
ASN A 396
LEU A 311
LEU A 318
 None
 1.32A 3ndvC-4q62A:
undetectable
3ndvD-4q62A:
undetectable		 3ndvC-4q62A:
19.86
3ndvD-4q62A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_D_AICD374_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 4q62 LEUCINE-RICH
REPEAT-AND COILED
COIL-CONTAINING
PROTEIN
(Legionella
pneumophila) 		5 / 11 LEU A 318
THR A 371
LEU A 368
ASN A 396
LEU A 311
 None
 1.33A 3ndvC-4q62A:
undetectable
3ndvD-4q62A:
undetectable		 3ndvC-4q62A:
19.86
3ndvD-4q62A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 4q62 LEUCINE-RICH
REPEAT-AND COILED
COIL-CONTAINING
PROTEIN
(Legionella
pneumophila) 		4 / 8 LEU A 250
ILE A 228
VAL A 201
GLY A 222
 SO4  A 504 (-4.5A)
None
None
None
 0.89A 4eq4B-4q62A:
undetectable		 4eq4B-4q62A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4q62 LEUCINE-RICH
REPEAT-AND COILED
COIL-CONTAINING
PROTEIN
(Legionella
pneumophila) 		5 / 12 LEU A 287
LEU A 311
LEU A 363
ILE A 277
THR A 356
 None
 1.19A 4f4dB-4q62A:
undetectable		 4f4dB-4q62A:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 4q62 LEUCINE-RICH
REPEAT-AND COILED
COIL-CONTAINING
PROTEIN
(Legionella
pneumophila) 		5 / 6 LYS A 159
LEU A 161
PHE A 179
PHE A 164
LEU A 136
 None
 1.46A 5x19P-4q62A:
undetectable		 5x19P-4q62A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_P_CHDP304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4q62 LEUCINE-RICH
REPEAT-AND COILED
COIL-CONTAINING
PROTEIN
(Legionella
pneumophila) 		5 / 7 LYS A 159
LEU A 161
PHE A 179
PHE A 164
LEU A 136
 None
 1.47A 5x1fP-4q62A:
undetectable
5x1fW-4q62A:
undetectable		 5x1fP-4q62A:
18.18
5x1fW-4q62A:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_2
(CYTOCHROME P450 2C9)		 4q62 LEUCINE-RICH
REPEAT-AND COILED
COIL-CONTAINING
PROTEIN
(Legionella
pneumophila) 		3 / 3 LEU A 207
VAL A 176
ASP A 177
 None
 0.58A 5x23A-4q62A:
undetectable		 5x23A-4q62A:
21.80