SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4q65'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_1
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 4q65 DIPEPTIDE PERMEASE D
(Escherichia
coli) 		4 / 4 THR A 463
LEU A 467
VAL A 470
LEU A 474
 None
 0.53A 1fbmB-4q65A:
undetectable		 1fbmB-4q65A:
7.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_2
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 4q65 DIPEPTIDE PERMEASE D
(Escherichia
coli) 		4 / 4 THR A 463
LEU A 467
VAL A 470
LEU A 474
 None
 0.57A 1fbmD-4q65A:
undetectable		 1fbmD-4q65A:
7.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KB9_A_PCFA514_0
(CYTOCHROME B
CYTOCHROME C1, HEME
PROTEIN
UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 4q65 DIPEPTIDE PERMEASE D
(Escherichia
coli) 		4 / 8 ILE A 316
PHE A 313
VAL A 299
SER A 365
 None
 0.99A 1kb9A-4q65A:
undetectable
1kb9C-4q65A:
4.0
1kb9D-4q65A:
undetectable
1kb9E-4q65A:
undetectable		 1kb9A-4q65A:
21.81
1kb9C-4q65A:
21.40
1kb9D-4q65A:
18.14
1kb9E-4q65A:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 4q65 DIPEPTIDE PERMEASE D
(Escherichia
coli) 		4 / 4 THR A 463
LEU A 467
VAL A 470
LEU A 474
 None
 0.71A 1mz9D-4q65A:
undetectable		 1mz9D-4q65A:
7.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_A_IMNA379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 4q65 DIPEPTIDE PERMEASE D
(Escherichia
coli) 		5 / 12 PRO A 378
PRO A 309
TYR A 294
ILE A 295
LEU A 362
 None
 1.44A 1z9hA-4q65A:
undetectable		 1z9hA-4q65A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_B_IMNB381_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 4q65 DIPEPTIDE PERMEASE D
(Escherichia
coli) 		5 / 12 PRO A 378
PRO A 309
TYR A 294
ILE A 295
LEU A 362
 None
 1.44A 1z9hB-4q65A:
undetectable		 1z9hB-4q65A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_C_IMNC379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 4q65 DIPEPTIDE PERMEASE D
(Escherichia
coli) 		5 / 12 PRO A 378
PRO A 309
TYR A 294
ILE A 295
LEU A 362
 None
 1.45A 1z9hC-4q65A:
undetectable		 1z9hC-4q65A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_B_GBNB914_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 4q65 DIPEPTIDE PERMEASE D
(Escherichia
coli) 		5 / 10 TYR A  35
GLY A  94
GLY A 172
ALA A 174
ALA A 175
 None
 1.10A 2ej3B-4q65A:
undetectable		 2ej3B-4q65A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7F_A_NIOA601_1
(NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE)		 4q65 DIPEPTIDE PERMEASE D
(Escherichia
coli) 		4 / 6 PHE A 140
SER A 122
GLY A 126
ARG A 136
 None
 1.23A 2f7fA-4q65A:
undetectable		 2f7fA-4q65A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_2
(MINERALOCORTICOID
RECEPTOR)		 4q65 DIPEPTIDE PERMEASE D
(Escherichia
coli) 		4 / 5 LEU A 230
LEU A 105
CYH A 112
THR A  61
 None
 1.08A 2oaxD-4q65A:
undetectable		 2oaxD-4q65A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4q65 DIPEPTIDE PERMEASE D
(Escherichia
coli) 		5 / 12 VAL A 473
ALA A 468
LEU A 279
PHE A 276
SER A 277
 None
 1.15A 2oipC-4q65A:
undetectable		 2oipC-4q65A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 4q65 DIPEPTIDE PERMEASE D
(Escherichia
coli) 		5 / 11 GLY A 288
PHE A 313
ALA A 284
ALA A 430
ALA A  30
 None
 0.88A 3g88A-4q65A:
undetectable		 3g88A-4q65A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 4q65 DIPEPTIDE PERMEASE D
(Escherichia
coli) 		5 / 11 GLY A 288
PHE A 313
ALA A 284
ALA A 430
ALA A  30
 None
 0.87A 3g88B-4q65A:
undetectable		 3g88B-4q65A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 4q65 DIPEPTIDE PERMEASE D
(Escherichia
coli) 		5 / 12 GLY A 288
PHE A 313
ALA A 284
ALA A 430
ALA A  30
 None
 0.87A 3g89A-4q65A:
undetectable		 3g89A-4q65A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 4q65 DIPEPTIDE PERMEASE D
(Escherichia
coli) 		5 / 11 GLY A 288
PHE A 313
ALA A 284
ALA A 430
ALA A  30
 None
 0.87A 3g89B-4q65A:
undetectable		 3g89B-4q65A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 4q65 DIPEPTIDE PERMEASE D
(Escherichia
coli) 		5 / 12 GLY A 288
PHE A 313
ALA A 284
ALA A 430
ALA A  30
 None
 0.87A 3g8bA-4q65A:
undetectable		 3g8bA-4q65A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 4q65 DIPEPTIDE PERMEASE D
(Escherichia
coli) 		5 / 12 GLY A 288
PHE A 313
ALA A 284
ALA A 430
ALA A  30
 None
 0.86A 3g8bB-4q65A:
undetectable		 3g8bB-4q65A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 4q65 DIPEPTIDE PERMEASE D
(Escherichia
coli) 		5 / 12 ALA A 466
GLY A 351
GLY A 353
ILE A 344
LEU A 273
 None
 0.99A 4n49A-4q65A:
undetectable		 4n49A-4q65A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_A_ACTA1923_0
(BETA-XYLOSIDASE)		 4q65 DIPEPTIDE PERMEASE D
(Escherichia
coli) 		3 / 3 ASP A 133
ARG A 135
TYR A 129
 None
 0.89A 5a7mA-4q65A:
undetectable		 5a7mA-4q65A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_B_ACTB1924_0
(BETA-XYLOSIDASE)		 4q65 DIPEPTIDE PERMEASE D
(Escherichia
coli) 		3 / 3 ASP A 133
ARG A 135
TYR A 129
 None
 0.88A 5a7mB-4q65A:
undetectable		 5a7mB-4q65A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS6_A_J3ZA302_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14)		 4q65 DIPEPTIDE PERMEASE D
(Escherichia
coli) 		4 / 8 GLN A 286
LEU A 384
LEU A 362
THR A 463
 None
 1.05A 5hs6A-4q65A:
undetectable		 5hs6A-4q65A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 4q65 DIPEPTIDE PERMEASE D
(Escherichia
coli) 		4 / 5 PRO A 155
LEU A 107
TYR A 114
PHE A 117
 None
 1.20A 5igjA-4q65A:
undetectable		 5igjA-4q65A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_A_P2EA1201_1
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 4q65 DIPEPTIDE PERMEASE D
(Escherichia
coli) 		4 / 4 PRO A   8
MET A 143
GLY A 147
VAL A  14
 None
 1.32A 6ak3A-4q65A:
2.5		 6ak3A-4q65A:
9.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EFN_A_SAMA501_0
(SPORULATION KILLING
FACTOR MATURATION
PROTEIN SKFB)		 4q65 DIPEPTIDE PERMEASE D
(Escherichia
coli) 		5 / 11 GLU A  49
SER A  56
ALA A 424
LEU A  64
ALA A 222
 None
 1.33A 6efnA-4q65A:
undetectable		 6efnA-4q65A:
22.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6GS4_A_F9EA601_0
(DIPEPTIDE AND
TRIPEPTIDE PERMEASE
A)		 4q65 DIPEPTIDE PERMEASE D
(Escherichia
coli) 		6 / 10 TYR A  26
LYS A 118
ASN A 148
SER A 151
ASN A 317
GLU A 391
 None
 1.14A 6gs4A-4q65A:
43.5		 6gs4A-4q65A:
31.26