SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4q66'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2887_1
(AMINOMETHYLTRANSFERA
SE)		 4q66 PROTEIN BCH1
(Saccharomyces
cerevisiae) 		3 / 3 ASP K 256
GLU K 383
ARG K 308
 None
 0.88A 1wopA-4q66K:
undetectable		 1wopA-4q66K:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_B_ACTB294_0
(GLYCINE
N-METHYLTRANSFERASE)		 4q66 PROTEIN BCH1
(Saccharomyces
cerevisiae) 		4 / 6 ALA K 302
TYR K 310
ILE K 307
LEU K 292
 None
 1.01A 1xvaA-4q66K:
undetectable
1xvaB-4q66K:
undetectable		 1xvaA-4q66K:
16.84
1xvaB-4q66K:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVO_B_MK1B902_1
(POL POLYPROTEIN)		 4q66 PROTEIN BCH1
(Saccharomyces
cerevisiae) 		5 / 9 LEU K 615
ILE K 668
ILE K 672
VAL K 656
ILE K 659
 None
 1.09A 2avoA-4q66K:
undetectable		 2avoA-4q66K:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZQ_A_PCFA954_0
(CATECHOL
1,2-DIOXYGENASE)		 4q66 PROTEIN BCH1
(Saccharomyces
cerevisiae) 		5 / 9 LEU K 351
HIS K 299
ALA K 302
LEU K 292
GLU K 297
 None
 1.28A 2azqA-4q66K:
0.0		 2azqA-4q66K:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OBV_A_SAMA501_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-1)		 4q66 PROTEIN BCH1
(Saccharomyces
cerevisiae) 		4 / 8 HIS K 260
PRO K 258
LYS K 385
SER K 349
 None
 1.09A 2obvA-4q66K:
undetectable		 2obvA-4q66K:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 4q66 PROTEIN BCH1
(Saccharomyces
cerevisiae) 		3 / 3 VAL K 320
ASP K 321
GLU K 316
 None
 0.74A 2qeuA-4q66K:
2.8		 2qeuA-4q66K:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_C_ACTC141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 4q66 PROTEIN BCH1
(Saccharomyces
cerevisiae) 		3 / 3 VAL K 320
ASP K 321
GLU K 316
 None
 0.70A 2qeuC-4q66K:
2.0		 2qeuC-4q66K:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4q66 PROTEIN BCH1
(Saccharomyces
cerevisiae) 		4 / 5 PHE K 229
PHE K 713
LEU K 714
PHE K 722
 None
 1.33A 3abmC-4q66K:
1.2
3abmJ-4q66K:
undetectable		 3abmC-4q66K:
17.17
3abmJ-4q66K:
5.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4q66 PROTEIN BCH1
(Saccharomyces
cerevisiae) 		4 / 5 PHE K 229
PHE K 713
LEU K 714
PHE K 722
 None
 1.34A 3ag3C-4q66K:
1.7
3ag3J-4q66K:
undetectable		 3ag3C-4q66K:
17.17
3ag3J-4q66K:
5.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_2
(HIV-1 PROTEASE)		 4q66 PROTEIN BCH1
(Saccharomyces
cerevisiae) 		3 / 3 ARG K 212
VAL K 202
THR K 274
 None
 0.87A 3cyxA-4q66K:
undetectable		 3cyxA-4q66K:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_1
(PUTATIVE RRNA
METHYLASE)		 4q66 PROTEIN BCH1
(Saccharomyces
cerevisiae) 		3 / 3 ASN K 716
ASP K 708
GLN K 704
 None
 0.74A 3eeyC-4q66K:
undetectable		 3eeyC-4q66K:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_1
(PUTATIVE RRNA
METHYLASE)		 4q66 PROTEIN BCH1
(Saccharomyces
cerevisiae) 		3 / 3 ASN K 716
ASP K 708
GLN K 704
 None
 0.74A 3eeyD-4q66K:
undetectable		 3eeyD-4q66K:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_1
(PUTATIVE RRNA
METHYLASE)		 4q66 PROTEIN BCH1
(Saccharomyces
cerevisiae) 		3 / 3 ASN K 716
ASP K 708
GLN K 704
 None
 0.73A 3eeyE-4q66K:
undetectable		 3eeyE-4q66K:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_1
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 4q66 PROTEIN BCH1
(Saccharomyces
cerevisiae) 		3 / 3 ARG K 308
ASP K 210
GLN K 478
 None
 0.88A 3lcvB-4q66K:
undetectable		 3lcvB-4q66K:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA309_1
(BETA-LACTAMASE)		 4q66 PROTEIN BCH1
(Saccharomyces
cerevisiae) 		4 / 5 ILE K 710
ARG K 280
GLU K 216
GLU K 277
 None
 1.37A 3ny4A-4q66K:
undetectable		 3ny4A-4q66K:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UWL_D_FOZD316_0
(THYMIDYLATE SYNTHASE)		 4q66 PROTEIN BCH1
(Saccharomyces
cerevisiae) 		5 / 12 LEU K 588
LEU K 496
GLY K 492
TYR K 499
ILE K 487
 None
 1.09A 3uwlD-4q66K:
undetectable		 3uwlD-4q66K:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UY4_A_PAUA302_0
(PANTOTHENATE
SYNTHETASE)		 4q66 PROTEIN BCH1
(Saccharomyces
cerevisiae) 		4 / 8 ARG K 212
VAL K 656
GLN K 616
ARG K 280
 None
 1.18A 3uy4A-4q66K:
undetectable		 3uy4A-4q66K:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4q66 PROTEIN BCH1
(Saccharomyces
cerevisiae) 		4 / 8 HIS K 260
PRO K 258
LYS K 385
SER K 349
 None
 1.09A 4kttA-4q66K:
undetectable		 4kttA-4q66K:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_B_C2FB4000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 4q66 PROTEIN BCH1
(Saccharomyces
cerevisiae) 		5 / 12 ILE K 205
ILE K  38
SER K 231
ILE K  97
ASN K 240
 None
 1.16A 4o1eB-4q66K:
undetectable		 4o1eB-4q66K:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_B_RBFB402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4q66 PROTEIN BCH1
(Saccharomyces
cerevisiae) 		5 / 12 LEU K 551
ALA K 480
ILE K 395
GLY K 589
GLN K 489
 None
 0.85A 4r3aB-4q66K:
undetectable		 4r3aB-4q66K:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0R_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 4q66 PROTEIN BCH1
(Saccharomyces
cerevisiae) 		5 / 12 LEU K 327
ILE K 323
ILE K 307
VAL K 303
PHE K 333
 None
 0.86A 4y0rA-4q66K:
undetectable		 4y0rA-4q66K:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_A_ACTA401_0
(PROTON-GATED ION
CHANNEL)		 4q66 PROTEIN BCH1
(Saccharomyces
cerevisiae) 		4 / 6 ILE K 112
PHE K 116
ILE K   7
GLU K   9
 None
 1.22A 4zzcA-4q66K:
undetectable
4zzcB-4q66K:
undetectable		 4zzcA-4q66K:
20.77
4zzcB-4q66K:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_B_ACTB401_0
(PROTON-GATED ION
CHANNEL)		 4q66 PROTEIN BCH1
(Saccharomyces
cerevisiae) 		4 / 6 ILE K 112
PHE K 116
ILE K   7
GLU K   9
 None
 1.25A 4zzcB-4q66K:
undetectable
4zzcC-4q66K:
undetectable		 4zzcB-4q66K:
20.77
4zzcC-4q66K:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CR1_A_T44A201_1
(TRANSTHYRETIN)		 4q66 PROTEIN BCH1
(Saccharomyces
cerevisiae) 		4 / 5 LYS K 370
ALA K 373
LEU K 360
VAL K 377
 None
 1.17A 5cr1A-4q66K:
undetectable		 5cr1A-4q66K:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIH_A_8CVA201_1
(DIHYDROFOLATE
REDUCTASE)		 4q66 PROTEIN BCH1
(Saccharomyces
cerevisiae) 		4 / 8 ALA K 403
LEU K 484
ILE K 490
THR K 391
 None
 0.85A 5uihA-4q66K:
undetectable		 5uihA-4q66K:
7.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z3J_A_NCAA302_0
(ABRIN A-CHAIN)		 4q66 PROTEIN BCH1
(Saccharomyces
cerevisiae) 		4 / 6 VAL K 189
TYR K 146
ILE K 192
GLU K 195
 None
 1.05A 5z3jA-4q66K:
undetectable		 5z3jA-4q66K:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		 4q66 PROTEIN BCH1
(Saccharomyces
cerevisiae) 		4 / 6 THR K 485
LEU K 484
MET K 400
LEU K 479
 None
 1.20A 6mvxA-4q66K:
undetectable
6mvxB-4q66K:
2.7
6mvxC-4q66K:
2.6		 6mvxA-4q66K:
17.32
6mvxB-4q66K:
17.32
6mvxC-4q66K:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4q66 PROTEIN BCH1
(Saccharomyces
cerevisiae) 		4 / 6 LYS K 482
GLN K 478
PHE K 477
LEU K 407
 None
 1.24A 6nmpC-4q66K:
1.1
6nmpJ-4q66K:
undetectable		 6nmpC-4q66K:
17.17
6nmpJ-4q66K:
5.82