SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4q6g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4002_1
(SERUM ALBUMIN)		 4q6g PYRROLYSINE--TRNA
LIGASE
(Methanosarcina
mazei) 		3 / 3 PHE A 347
LEU A 367
SER A 398
 None
 0.81A 1e7aA-4q6gA:
undetectable		 1e7aA-4q6gA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		 4q6g PYRROLYSINE--TRNA
LIGASE
(Methanosarcina
mazei) 		3 / 3 ASP A 206
LEU A 201
LEU A 202
 None
 0.73A 1ikeA-4q6gA:
undetectable		 1ikeA-4q6gA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		 4q6g PYRROLYSINE--TRNA
LIGASE
(Methanosarcina
mazei) 		3 / 3 ASP A 206
LEU A 201
LEU A 202
 None
 0.74A 1np1B-4q6gA:
undetectable		 1np1B-4q6gA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDW_B_017B401_1
(PROTEASE)		 4q6g PYRROLYSINE--TRNA
LIGASE
(Methanosarcina
mazei) 		5 / 11 ASP A 408
ILE A 305
GLY A 419
ILE A 418
ILE A 413
 None
ALY  A 508 ( 4.6A)
ALY  A 508 ( 4.3A)
None
EDO  A 506 ( 4.7A)
 1.14A 2idwA-4q6gA:
undetectable		 2idwA-4q6gA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4q6g PYRROLYSINE--TRNA
LIGASE
(Methanosarcina
mazei) 		4 / 8 PHE A 306
ILE A 413
PHE A 348
GLY A 403
 ALY  A 508 ( 4.8A)
EDO  A 506 ( 4.7A)
ALY  A 508 (-4.9A)
None
 0.88A 2qwxA-4q6gA:
undetectable
2qwxB-4q6gA:
undetectable		 2qwxA-4q6gA:
22.14
2qwxB-4q6gA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_B_1UNB900_1
(PROTEASE)		 4q6g PYRROLYSINE--TRNA
LIGASE
(Methanosarcina
mazei) 		5 / 9 ASP A 408
ILE A 305
GLY A 419
ILE A 418
ILE A 413
 None
ALY  A 508 ( 4.6A)
ALY  A 508 ( 4.3A)
None
EDO  A 506 ( 4.7A)
 1.10A 2r5qA-4q6gA:
undetectable		 2r5qA-4q6gA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_D_1UND900_1
(PROTEASE)		 4q6g PYRROLYSINE--TRNA
LIGASE
(Methanosarcina
mazei) 		5 / 9 ASP A 408
ILE A 305
GLY A 419
ILE A 418
ILE A 413
 None
ALY  A 508 ( 4.6A)
ALY  A 508 ( 4.3A)
None
EDO  A 506 ( 4.7A)
 1.10A 2r5qC-4q6gA:
undetectable		 2r5qC-4q6gA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_1
(WNT INHIBITORY
FACTOR 1)		 4q6g PYRROLYSINE--TRNA
LIGASE
(Methanosarcina
mazei) 		4 / 6 LEU A 284
ILE A 278
PRO A 299
VAL A 377
 None
 1.16A 2ygoA-4q6gA:
undetectable		 2ygoA-4q6gA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA606_1
(CHITINASE A)		 4q6g PYRROLYSINE--TRNA
LIGASE
(Methanosarcina
mazei) 		4 / 7 PHE A 374
GLY A 371
ASP A 365
ARG A 257
 None
 1.23A 3aruA-4q6gA:
undetectable		 3aruA-4q6gA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Z_B_017B201_1
(HIV-1 PROTEASE)		 4q6g PYRROLYSINE--TRNA
LIGASE
(Methanosarcina
mazei) 		5 / 12 ASP A 408
ILE A 305
GLY A 419
ILE A 418
ILE A 413
 None
ALY  A 508 ( 4.6A)
ALY  A 508 ( 4.3A)
None
EDO  A 506 ( 4.7A)
 0.99A 3d1zA-4q6gA:
undetectable		 3d1zA-4q6gA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKY_A_DR7A100_2
(PROTEASE)		 4q6g PYRROLYSINE--TRNA
LIGASE
(Methanosarcina
mazei) 		5 / 9 ASP A 408
ILE A 305
GLY A 419
ILE A 418
ILE A 413
 None
ALY  A 508 ( 4.6A)
ALY  A 508 ( 4.3A)
None
EDO  A 506 ( 4.7A)
 1.24A 3ekyB-4q6gA:
undetectable		 3ekyB-4q6gA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_0
(REPRESSOR PROTEIN
MPHR(A))		 4q6g PYRROLYSINE--TRNA
LIGASE
(Methanosarcina
mazei) 		5 / 12 GLY A 421
LEU A 284
ILE A 305
VAL A 383
ILE A 278
 ANP  A 501 (-4.8A)
None
ALY  A 508 ( 4.6A)
None
None
 1.04A 3frqB-4q6gA:
undetectable		 3frqB-4q6gA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDW_A_RITA100_2
(PROTEASE)		 4q6g PYRROLYSINE--TRNA
LIGASE
(Methanosarcina
mazei) 		5 / 9 ASP A 408
ILE A 305
GLY A 419
ILE A 418
ILE A 413
 None
ALY  A 508 ( 4.6A)
ALY  A 508 ( 4.3A)
None
EDO  A 506 ( 4.7A)
 1.10A 3ndwB-4q6gA:
undetectable		 3ndwB-4q6gA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU3_B_478B401_1
(PROTEASE)		 4q6g PYRROLYSINE--TRNA
LIGASE
(Methanosarcina
mazei) 		5 / 12 ASP A 408
ILE A 305
GLY A 419
ILE A 418
ILE A 413
 None
ALY  A 508 ( 4.6A)
ALY  A 508 ( 4.3A)
None
EDO  A 506 ( 4.7A)
 1.01A 3nu3A-4q6gA:
undetectable		 3nu3A-4q6gA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU6_B_478B401_1
(PROTEASE)		 4q6g PYRROLYSINE--TRNA
LIGASE
(Methanosarcina
mazei) 		5 / 10 ASP A 408
ILE A 305
GLY A 419
ILE A 418
ILE A 413
 None
ALY  A 508 ( 4.6A)
ALY  A 508 ( 4.3A)
None
EDO  A 506 ( 4.7A)
 1.00A 3nu6A-4q6gA:
undetectable		 3nu6A-4q6gA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUO_B_478B478_1
(PROTEASE)		 4q6g PYRROLYSINE--TRNA
LIGASE
(Methanosarcina
mazei) 		5 / 9 ASP A 408
ILE A 305
GLY A 419
ILE A 418
ILE A 413
 None
ALY  A 508 ( 4.6A)
ALY  A 508 ( 4.3A)
None
EDO  A 506 ( 4.7A)
 1.03A 3nuoA-4q6gA:
undetectable		 3nuoA-4q6gA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_2
(HIV-1 PROTEASE)		 4q6g PYRROLYSINE--TRNA
LIGASE
(Methanosarcina
mazei) 		5 / 12 ASP A 408
ILE A 305
GLY A 419
ILE A 418
ILE A 413
 None
ALY  A 508 ( 4.6A)
ALY  A 508 ( 4.3A)
None
EDO  A 506 ( 4.7A)
 1.03A 4jecB-4q6gA:
undetectable		 4jecB-4q6gA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_A_ML1A302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4q6g PYRROLYSINE--TRNA
LIGASE
(Methanosarcina
mazei) 		4 / 8 PHE A 306
ILE A 413
PHE A 348
GLY A 403
 ALY  A 508 ( 4.8A)
EDO  A 506 ( 4.7A)
ALY  A 508 (-4.9A)
None
 0.88A 4qogA-4q6gA:
undetectable
4qogB-4q6gA:
undetectable		 4qogA-4q6gA:
22.14
4qogB-4q6gA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJL_A_ERYA1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4q6g PYRROLYSINE--TRNA
LIGASE
(Methanosarcina
mazei) 		5 / 12 PHE A 366
GLU A 261
GLU A 425
THR A 343
GLY A 326
 None
 1.34A 4zjlA-4q6gA:
1.6		 4zjlA-4q6gA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 4q6g PYRROLYSINE--TRNA
LIGASE
(Methanosarcina
mazei) 		7 / 10 ARG A 330
GLU A 332
HIS A 338
GLU A 396
GLY A 423
ARG A 426
ILE A 437
 ANP  A 501 ( 3.2A)
ANP  A 501 (-4.0A)
ANP  A 501 (-3.9A)
ANP  A 501 (-3.2A)
ANP  A 501 (-3.5A)
ANP  A 501 (-2.7A)
None
 0.91A 6bniA-4q6gA:
16.6		 6bniA-4q6gA:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 4q6g PYRROLYSINE--TRNA
LIGASE
(Methanosarcina
mazei) 		7 / 10 ARG A 330
GLU A 332
HIS A 338
PHE A 342
GLY A 423
ARG A 426
ILE A 437
 ANP  A 501 ( 3.2A)
ANP  A 501 (-4.0A)
ANP  A 501 (-3.9A)
ANP  A 501 ( 3.6A)
ANP  A 501 (-3.5A)
ANP  A 501 (-2.7A)
None
 0.76A 6bniA-4q6gA:
16.6		 6bniA-4q6gA:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 4q6g PYRROLYSINE--TRNA
LIGASE
(Methanosarcina
mazei) 		7 / 10 ARG A 330
GLU A 332
HIS A 338
GLU A 396
GLY A 423
ARG A 426
ILE A 437
 ANP  A 501 ( 3.2A)
ANP  A 501 (-4.0A)
ANP  A 501 (-3.9A)
ANP  A 501 (-3.2A)
ANP  A 501 (-3.5A)
ANP  A 501 (-2.7A)
None
 0.92A 6bniB-4q6gA:
17.2		 6bniB-4q6gA:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 4q6g PYRROLYSINE--TRNA
LIGASE
(Methanosarcina
mazei) 		7 / 10 ARG A 330
GLU A 332
HIS A 338
PHE A 342
GLY A 423
ARG A 426
ILE A 437
 ANP  A 501 ( 3.2A)
ANP  A 501 (-4.0A)
ANP  A 501 (-3.9A)
ANP  A 501 ( 3.6A)
ANP  A 501 (-3.5A)
ANP  A 501 (-2.7A)
None
 0.80A 6bniB-4q6gA:
17.2		 6bniB-4q6gA:
10.07