SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4q6i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSD_C_DVAC2_0
(ACTINOMYCIN D)		 4q6i HEAVY CHAIN OF
MURINE 2D5 FAB
(Mus
musculus) 		4 / 4 THR B 116
PRO B 118
THR B 117
PRO B 147
 None
 1.35A 1dsdC-4q6iB:
undetectable		 1dsdC-4q6iB:
5.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSD_C_DVAC2_0
(ACTINOMYCIN D)		 4q6i HEAVY CHAIN OF
MURINE 2D5 FAB
(Mus
musculus) 		4 / 4 THR B 117
PRO B 147
THR B 116
PRO B 118
 None
 1.28A 1dsdC-4q6iB:
undetectable		 1dsdC-4q6iB:
5.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSD_C_DVAC8_0
(ACTINOMYCIN D)		 4q6i HEAVY CHAIN OF
MURINE 2D5 FAB
(Mus
musculus) 		4 / 4 THR B 116
PRO B 118
THR B 117
PRO B 147
 None
 1.35A 1dsdC-4q6iB:
undetectable		 1dsdC-4q6iB:
5.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSD_C_DVAC8_0
(ACTINOMYCIN D)		 4q6i HEAVY CHAIN OF
MURINE 2D5 FAB
(Mus
musculus) 		4 / 4 THR B 117
PRO B 147
THR B 116
PRO B 118
 None
 1.28A 1dsdC-4q6iB:
undetectable		 1dsdC-4q6iB:
5.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE9_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 4q6i T-CELL SURFACE
GLYCOPROTEIN CD4
(Homo
sapiens) 		5 / 12 LEU C   5
LEU C  96
VAL C  97
SER C  79
VAL C 161
 None
 1.38A 1ie9A-4q6iC:
undetectable		 1ie9A-4q6iC:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y03_A_5FWA601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 4q6i HEAVY CHAIN OF
MURINE 2D5 FAB
(Mus
musculus) 		5 / 12 VAL B 163
VAL B 181
SER B 179
ASN B 196
ASN B 155
 None
 1.45A 2y03A-4q6iB:
undetectable		 2y03A-4q6iB:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_1
(PUTATIVE RRNA
METHYLASE)		 4q6i T-CELL SURFACE
GLYCOPROTEIN CD4
(Homo
sapiens) 		3 / 3 ASN C 137
ASP C 153
GLN C 152
 None
 0.81A 3eeyC-4q6iC:
undetectable		 3eeyC-4q6iC:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_1
(PUTATIVE RRNA
METHYLASE)		 4q6i T-CELL SURFACE
GLYCOPROTEIN CD4
(Homo
sapiens) 		3 / 3 ASN C 137
ASP C 153
GLN C 152
 None
 0.80A 3eeyD-4q6iC:
undetectable		 3eeyD-4q6iC:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_1
(PUTATIVE RRNA
METHYLASE)		 4q6i T-CELL SURFACE
GLYCOPROTEIN CD4
(Homo
sapiens) 		3 / 3 ASN C 137
ASP C 153
GLN C 152
 None
 0.81A 3eeyE-4q6iC:
undetectable		 3eeyE-4q6iC:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NYA_A_JTZA1203_1
(BETA-2 ADRENERGIC
RECEPTOR, LYSOZYME)		 4q6i HEAVY CHAIN OF
MURINE 2D5 FAB
(Mus
musculus) 		5 / 12 VAL B 163
VAL B 181
SER B 179
ASN B 196
ASN B 155
 None
 1.40A 3nyaA-4q6iB:
undetectable		 3nyaA-4q6iB:
16.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M7K_H_ACTH302_0
(10H10 HEAVY CHAIN)		 4q6i HEAVY CHAIN OF
MURINE 2D5 FAB
(Mus
musculus) 		4 / 5 VAL B   2
TYR B  27
ARG B  94
TYR B 102
 None
 0.38A 4m7kH-4q6iB:
24.6		 4m7kH-4q6iB:
57.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB603_1
(SERUM ALBUMIN)		 4q6i T-CELL SURFACE
GLYCOPROTEIN CD4
(Homo
sapiens) 		5 / 11 LEU C  74
SER C  79
VAL C 168
LEU C   5
LEU C  95
 None
 1.22A 4or0B-4q6iC:
undetectable		 4or0B-4q6iC:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECM_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4q6i HEAVY CHAIN OF
MURINE 2D5 FAB
(Mus
musculus) 		4 / 7 ALA B  88
THR B  87
VAL B 109
GLU B  85
 None
 0.75A 5ecmD-4q6iB:
undetectable		 5ecmD-4q6iB:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECO_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4q6i HEAVY CHAIN OF
MURINE 2D5 FAB
(Mus
musculus) 		4 / 7 ALA B  88
THR B  87
VAL B 109
GLU B  85
 None
 0.81A 5ecoD-4q6iB:
undetectable		 5ecoD-4q6iB:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA820_0
(GEPHYRIN)		 4q6i HEAVY CHAIN OF
MURINE 2D5 FAB
(Mus
musculus) 		4 / 5 GLU B  10
PRO B   9
THR B 107
GLN B 105
 None
 1.07A 6fgdA-4q6iB:
undetectable		 6fgdA-4q6iB:
18.68