SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4q6j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_2
(TUBULIN BETA-2B
CHAIN)		 4q6j LMO0131 PROTEIN
(Listeria
monocytogenes) 		5 / 12 LEU A  60
ALA A  62
ASN A  15
ALA A  11
ILE A   8
 None
 1.05A 4o2bB-4q6jA:
undetectable		 4o2bB-4q6jA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 4q6j LMO0131 PROTEIN
(Listeria
monocytogenes) 		4 / 6 GLY A 210
GLU A 209
ASP A 213
ASP A 175
 EDO  A 309 (-3.4A)
None
GOL  A 306 (-3.0A)
None
 1.02A 4uckB-4q6jA:
undetectable		 4uckB-4q6jA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNU_A_BEZA319_0
(SHKAI2IB)		 4q6j LMO0131 PROTEIN
(Listeria
monocytogenes) 		4 / 5 GLN A  77
ILE A  87
ILE A  89
TYR A  21
 None
 1.03A 5dnuA-4q6jA:
undetectable		 5dnuA-4q6jA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNV_A_BEZA304_0
(SHKAI2IB)		 4q6j LMO0131 PROTEIN
(Listeria
monocytogenes) 		4 / 5 GLN A  77
ILE A  87
ILE A  89
TYR A  21
 None
 0.99A 5dnvA-4q6jA:
undetectable		 5dnvA-4q6jA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ITZ_B_LOCB502_1
(TUBULIN BETA-2B
CHAIN)		 4q6j LMO0131 PROTEIN
(Listeria
monocytogenes) 		5 / 12 LEU A  60
ALA A  62
ASN A  15
ALA A  11
ILE A   8
 None
 1.12A 5itzB-4q6jA:
undetectable		 5itzB-4q6jA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_A_FUAA1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4q6j LMO0131 PROTEIN
(Listeria
monocytogenes) 		4 / 5 ILE A  89
LYS A 143
ILE A 142
VAL A 109
 None
 0.90A 5jmnA-4q6jA:
undetectable		 5jmnA-4q6jA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIO_B_LOCB502_1
(TUBULIN BETA CHAIN)		 4q6j LMO0131 PROTEIN
(Listeria
monocytogenes) 		5 / 12 LEU A  60
ALA A  62
ASN A  15
ALA A  11
ILE A   8
 None
 1.02A 5mioB-4q6jA:
undetectable		 5mioB-4q6jA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVN_B_PFLB410_1
(PROTON-GATED ION
CHANNEL)		 4q6j LMO0131 PROTEIN
(Listeria
monocytogenes) 		5 / 9 ILE A 121
ILE A  89
VAL A 147
TYR A 108
ILE A  75
 None
None
None
EDO  A 304 ( 4.1A)
None
 1.38A 5mvnB-4q6jA:
undetectable		 5mvnB-4q6jA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVN_D_PFLD410_1
(PROTON-GATED ION
CHANNEL)		 4q6j LMO0131 PROTEIN
(Listeria
monocytogenes) 		5 / 10 ILE A 121
ILE A  89
VAL A 147
TYR A 108
ILE A  75
 None
None
None
EDO  A 304 ( 4.1A)
None
 1.36A 5mvnD-4q6jA:
undetectable		 5mvnD-4q6jA:
15.35