SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4q6p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_B_SAMB400_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 4q6p CONSERVED
HYPOTHETICAL
SECRETED PROTEIN
(Helicobacter
pylori) 		5 / 9 LEU A 183
GLU A 187
LEU A 227
HIS A 236
GLY A  51
 None
 1.42A 1mjlA-4q6pA:
undetectable
1mjlB-4q6pA:
undetectable		 1mjlA-4q6pA:
13.75
1mjlB-4q6pA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_A_MTXA351_1
(PTERIDINE REDUCTASE
1)		 4q6p CONSERVED
HYPOTHETICAL
SECRETED PROTEIN
(Helicobacter
pylori) 		5 / 12 SER A 308
LEU A 412
LEU A 434
PRO A 279
MET A 432
 None
 1.41A 1p33A-4q6pA:
2.7		 1p33A-4q6pA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_B_MTXB352_1
(PTERIDINE REDUCTASE
1)		 4q6p CONSERVED
HYPOTHETICAL
SECRETED PROTEIN
(Helicobacter
pylori) 		5 / 12 SER A 308
LEU A 412
LEU A 434
PRO A 279
MET A 432
 None
 1.49A 1p33B-4q6pA:
undetectable		 1p33B-4q6pA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_C_MTXC353_1
(PTERIDINE REDUCTASE
1)		 4q6p CONSERVED
HYPOTHETICAL
SECRETED PROTEIN
(Helicobacter
pylori) 		5 / 12 SER A 308
LEU A 412
LEU A 434
PRO A 279
MET A 432
 None
 1.45A 1p33C-4q6pA:
undetectable		 1p33C-4q6pA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_B_SALB503_1
(SALICYLATE
SYNTHETASE, IRP9)		 4q6p CONSERVED
HYPOTHETICAL
SECRETED PROTEIN
(Helicobacter
pylori) 		5 / 11 ILE A  45
GLU A 222
GLY A  52
HIS A 236
GLY A  44
 None
API  A 510 (-3.6A)
None
None
None
 1.45A 2fn1B-4q6pA:
undetectable		 2fn1B-4q6pA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CD2_A_MTXA307_1
(DIHYDROFOLATE
REDUCTASE)		 4q6p CONSERVED
HYPOTHETICAL
SECRETED PROTEIN
(Helicobacter
pylori) 		5 / 12 LEU A 286
SER A 335
PHE A 323
LEU A 315
ILE A 275
 None
 0.97A 3cd2A-4q6pA:
undetectable		 3cd2A-4q6pA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_J_SAMJ300_0
(PUTATIVE RRNA
METHYLASE)		 4q6p CONSERVED
HYPOTHETICAL
SECRETED PROTEIN
(Helicobacter
pylori) 		5 / 12 GLY A  51
ASN A  54
ASP A 129
GLY A 131
LEU A 229
 None
 1.06A 3eeyJ-4q6pA:
undetectable		 3eeyJ-4q6pA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_J_SAMJ300_0
(PUTATIVE RRNA
METHYLASE)		 4q6p CONSERVED
HYPOTHETICAL
SECRETED PROTEIN
(Helicobacter
pylori) 		5 / 12 GLY A  51
ASN A  54
ASP A 129
GLY A 149
LEU A 229
 None
 1.05A 3eeyJ-4q6pA:
undetectable		 3eeyJ-4q6pA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB201_1
(PROTEIN S100-A4)		 4q6p CONSERVED
HYPOTHETICAL
SECRETED PROTEIN
(Helicobacter
pylori) 		4 / 8 ILE A 433
PHE A 386
PHE A 406
PHE A 437
 None
 0.97A 3ko0B-4q6pA:
undetectable
3ko0J-4q6pA:
undetectable		 3ko0B-4q6pA:
13.56
3ko0J-4q6pA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK201_1
(PROTEIN S100-A4)		 4q6p CONSERVED
HYPOTHETICAL
SECRETED PROTEIN
(Helicobacter
pylori) 		4 / 8 ILE A 433
PHE A 386
PHE A 406
PHE A 437
 None
 0.94A 3ko0K-4q6pA:
undetectable
3ko0S-4q6pA:
undetectable		 3ko0K-4q6pA:
13.56
3ko0S-4q6pA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4q6p CONSERVED
HYPOTHETICAL
SECRETED PROTEIN
(Helicobacter
pylori) 		5 / 12 HIS A 236
GLY A  51
ILE A 153
GLY A 130
ALA A 223
 None
 1.10A 3sudB-4q6pA:
undetectable		 3sudB-4q6pA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5J_A_08HA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 4q6p CONSERVED
HYPOTHETICAL
SECRETED PROTEIN
(Helicobacter
pylori) 		4 / 7 LEU A 283
LEU A 271
ASN A  57
ILE A 312
 None
 0.92A 3u5jA-4q6pA:
undetectable		 3u5jA-4q6pA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_C_TYLC1184_1
(BROMODOMAIN
CONTAINING 2)		 4q6p CONSERVED
HYPOTHETICAL
SECRETED PROTEIN
(Helicobacter
pylori) 		4 / 5 LEU A 283
LEU A 271
ASN A  57
ILE A 312
 None
 0.95A 4a9jC-4q6pA:
undetectable		 4a9jC-4q6pA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI507_0
(RNA POLYMERASE
3D-POL)		 4q6p CONSERVED
HYPOTHETICAL
SECRETED PROTEIN
(Helicobacter
pylori) 		3 / 3 LYS A 118
PRO A 119
SER A 120
 None
 0.43A 4k50I-4q6pA:
undetectable		 4k50I-4q6pA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_A_ADNA501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 4q6p CONSERVED
HYPOTHETICAL
SECRETED PROTEIN
(Helicobacter
pylori) 		5 / 12 VAL A  75
ASP A  48
PHE A  53
GLY A  52
ASP A 129
 None
 1.45A 4pevA-4q6pA:
2.7		 4pevA-4q6pA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 4q6p CONSERVED
HYPOTHETICAL
SECRETED PROTEIN
(Helicobacter
pylori) 		5 / 12 VAL A  75
ASP A  48
PHE A  53
GLY A  52
ASP A 129
 None
 1.42A 4pevB-4q6pA:
2.5		 4pevB-4q6pA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 4q6p CONSERVED
HYPOTHETICAL
SECRETED PROTEIN
(Helicobacter
pylori) 		5 / 12 VAL A  75
ASP A  48
PHE A  53
GLY A  52
ASP A 129
 None
 1.40A 4pevC-4q6pA:
3.0		 4pevC-4q6pA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 4q6p CONSERVED
HYPOTHETICAL
SECRETED PROTEIN
(Helicobacter
pylori) 		5 / 12 GLY A  51
ALA A 223
ALA A 239
ILE A 240
LEU A 237
 None
 0.92A 5bw4B-4q6pA:
undetectable		 5bw4B-4q6pA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_1
(ESTROGEN RECEPTOR)		 4q6p CONSERVED
HYPOTHETICAL
SECRETED PROTEIN
(Helicobacter
pylori) 		5 / 12 THR A  56
LEU A  58
ALA A  55
LEU A 229
MET A  81
 None
 1.08A 5gs4A-4q6pA:
undetectable		 5gs4A-4q6pA:
20.33