SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4q6r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_2
(PROTEIN (ADENOSINE
KINASE))		 4q6r SPHINGOSINE-1-PHOSPH
ATE LYASE 1
(Homo
sapiens) 		3 / 3 LEU A 463
SER A 482
ASN A 475
 None
 0.77A 1bx4A-4q6rA:
undetectable		 1bx4A-4q6rA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 4q6r SPHINGOSINE-1-PHOSPH
ATE LYASE 1
(Homo
sapiens) 		5 / 10 LEU A 434
LEU A 453
PHE A 429
THR A 426
ILE A 487
 None
 1.41A 1i18A-4q6rA:
undetectable
1i18B-4q6rA:
undetectable		 1i18A-4q6rA:
11.99
1i18B-4q6rA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 4q6r SPHINGOSINE-1-PHOSPH
ATE LYASE 1
(Homo
sapiens) 		5 / 10 PHE A 429
THR A 426
ILE A 487
LEU A 434
LEU A 453
 None
 1.41A 1i18A-4q6rA:
undetectable
1i18B-4q6rA:
undetectable		 1i18A-4q6rA:
11.99
1i18B-4q6rA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4q6r SPHINGOSINE-1-PHOSPH
ATE LYASE 1
(Homo
sapiens) 		4 / 5 SER A 482
PHE A 500
VAL A 442
PHE A 443
 None
 1.30A 1oipA-4q6rA:
undetectable		 1oipA-4q6rA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OSV_B_CHCB201_1
(BILE ACID RECEPTOR)		 4q6r SPHINGOSINE-1-PHOSPH
ATE LYASE 1
(Homo
sapiens) 		5 / 12 LEU A 453
MET A 467
SER A 507
ILE A 511
ILE A 440
 None
None
None
GOL  A 902 ( 4.7A)
None
 1.44A 1osvB-4q6rA:
undetectable		 1osvB-4q6rA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 4q6r SPHINGOSINE-1-PHOSPH
ATE LYASE 1
(Homo
sapiens) 		5 / 12 ILE A 423
ILE A 424
ALA A 427
LEU A 333
ILE A 295
 None
 1.22A 1xzxX-4q6rA:
undetectable		 1xzxX-4q6rA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX95_0
(PROTEIN S100-B)		 4q6r SPHINGOSINE-1-PHOSPH
ATE LYASE 1
(Homo
sapiens) 		3 / 3 CYH A 193
PHE A 196
PHE A 339
 None
 0.82A 3cr5X-4q6rA:
undetectable		 3cr5X-4q6rA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FW1_A_STIA233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4q6r SPHINGOSINE-1-PHOSPH
ATE LYASE 1
(Homo
sapiens) 		5 / 10 GLY A 398
GLY A 399
TYR A 164
GLU A 185
ILE A 184
 None
 1.06A 3fw1A-4q6rA:
2.1		 3fw1A-4q6rA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_A_XRAA233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4q6r SPHINGOSINE-1-PHOSPH
ATE LYASE 1
(Homo
sapiens) 		5 / 9 GLY A 398
GLY A 399
TYR A 164
GLU A 185
ILE A 184
 None
 1.07A 3owxA-4q6rA:
undetectable		 3owxA-4q6rA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_B_XRAB233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4q6r SPHINGOSINE-1-PHOSPH
ATE LYASE 1
(Homo
sapiens) 		5 / 11 GLY A 398
GLY A 399
TYR A 164
GLU A 185
ILE A 184
 None
 1.17A 3owxA-4q6rA:
undetectable
3owxB-4q6rA:
undetectable		 3owxA-4q6rA:
20.35
3owxB-4q6rA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4q6r SPHINGOSINE-1-PHOSPH
ATE LYASE 1
(Homo
sapiens) 		5 / 12 TYR A 150
GLY A 355
ILE A 184
ALA A 407
ALA A 403
 LLP  A 353 (-3.8A)
LLP  A 353 ( 4.1A)
None
None
None
 1.02A 3sudB-4q6rA:
undetectable		 3sudB-4q6rA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4q6r SPHINGOSINE-1-PHOSPH
ATE LYASE 1
(Homo
sapiens) 		5 / 12 ILE A 423
ILE A 424
ALA A 427
LEU A 333
ILE A 295
 None
 1.01A 3uvvA-4q6rA:
undetectable		 3uvvA-4q6rA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BVA_B_T3B1314_1
(THIOMORPHOLINE-CARBO
XYLATE DEHYDROGENASE)		 4q6r SPHINGOSINE-1-PHOSPH
ATE LYASE 1
(Homo
sapiens) 		5 / 12 VAL A 450
PHE A 290
GLY A 293
VAL A 294
SER A 482
 None
SIN  A 901 (-4.0A)
None
None
None
 1.36A 4bvaB-4q6rA:
2.4		 4bvaB-4q6rA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4q6r SPHINGOSINE-1-PHOSPH
ATE LYASE 1
(Homo
sapiens) 		4 / 7 GLY A 398
GLY A 399
TYR A 164
GLU A 185
 None
 1.08A 4fgkB-4q6rA:
2.1		 4fgkB-4q6rA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_A_CLQA303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4q6r SPHINGOSINE-1-PHOSPH
ATE LYASE 1
(Homo
sapiens) 		5 / 12 GLY A 398
GLY A 399
TYR A 164
GLU A 185
ILE A 184
 None
 1.13A 4fglA-4q6rA:
undetectable
4fglB-4q6rA:
undetectable		 4fglA-4q6rA:
20.35
4fglB-4q6rA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4q6r SPHINGOSINE-1-PHOSPH
ATE LYASE 1
(Homo
sapiens) 		4 / 6 GLY A 398
GLY A 399
GLU A 185
ILE A 184
 None
 0.93A 4fglD-4q6rA:
undetectable		 4fglD-4q6rA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA302_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 4q6r SPHINGOSINE-1-PHOSPH
ATE LYASE 1
(Homo
sapiens) 		4 / 5 HIS A 484
TYR A 150
GLY A 147
SER A 146
 None
LLP  A 353 (-3.8A)
SIN  A 901 ( 4.0A)
None
 1.16A 4fu8A-4q6rA:
undetectable		 4fu8A-4q6rA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_A_LURA201_1
(TRANSTHYRETIN)		 4q6r SPHINGOSINE-1-PHOSPH
ATE LYASE 1
(Homo
sapiens) 		3 / 3 LYS A 247
LEU A 215
ALA A 244
 None
 0.85A 4iizA-4q6rA:
undetectable		 4iizA-4q6rA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_D_MTXD301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 4q6r SPHINGOSINE-1-PHOSPH
ATE LYASE 1
(Homo
sapiens) 		5 / 11 GLY A 454
ALA A 452
LEU A 453
HIS A 484
GLN A 476
 None
 1.14A 4l8fD-4q6rA:
2.2		 4l8fD-4q6rA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		 4q6r SPHINGOSINE-1-PHOSPH
ATE LYASE 1
(Homo
sapiens) 		4 / 6 ASP A 315
ASP A 350
ALA A 244
PHE A 245
 LLP  A 353 ( 2.9A)
LLP  A 353 ( 3.8A)
None
None
 1.12A 4nedA-4q6rA:
undetectable		 4nedA-4q6rA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OQR_A_2UOA502_1
(CYP105AS1)		 4q6r SPHINGOSINE-1-PHOSPH
ATE LYASE 1
(Homo
sapiens) 		5 / 9 PRO A 288
ILE A 424
ALA A 427
VAL A 442
ALA A 452
 None
 1.31A 4oqrA-4q6rA:
undetectable		 4oqrA-4q6rA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA610_0
(SERUM ALBUMIN)		 4q6r SPHINGOSINE-1-PHOSPH
ATE LYASE 1
(Homo
sapiens) 		3 / 3 TYR A 331
LYS A 425
LYS A 421
 None
 1.12A 5dbyA-4q6rA:
undetectable		 5dbyA-4q6rA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HHJ_B_GLYB404_0
(RETRON-TYPE REVERSE
TRANSCRIPTASE)		 4q6r SPHINGOSINE-1-PHOSPH
ATE LYASE 1
(Homo
sapiens) 		4 / 4 GLN A 478
ALA A 529
GLN A 530
THR A 532
 None
 1.21A 5hhjB-4q6rA:
undetectable		 5hhjB-4q6rA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_A_SAMA304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 4q6r SPHINGOSINE-1-PHOSPH
ATE LYASE 1
(Homo
sapiens) 		5 / 12 THR A 519
GLY A 521
ILE A 511
GLN A 510
LEU A 466
 GOL  A 902 (-4.5A)
None
GOL  A 902 ( 4.7A)
None
GOL  A 902 ( 4.6A)
 0.97A 5l0zA-4q6rA:
undetectable		 5l0zA-4q6rA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_B_SAMB304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 4q6r SPHINGOSINE-1-PHOSPH
ATE LYASE 1
(Homo
sapiens) 		5 / 10 THR A 519
GLY A 521
ILE A 511
GLN A 510
LEU A 466
 GOL  A 902 (-4.5A)
None
GOL  A 902 ( 4.7A)
None
GOL  A 902 ( 4.6A)
 0.97A 5l0zB-4q6rA:
undetectable		 5l0zB-4q6rA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4q6r SPHINGOSINE-1-PHOSPH
ATE LYASE 1
(Homo
sapiens) 		3 / 3 SER A 348
SER A 362
PHE A 245
 None
 0.93A 5mugA-4q6rA:
undetectable		 5mugA-4q6rA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNW_D_GCSD302_1
(25 KDA PROTEIN
ELICITOR)		 4q6r SPHINGOSINE-1-PHOSPH
ATE LYASE 1
(Homo
sapiens) 		4 / 7 ASP A 350
GLY A 209
HIS A 352
HIS A 242
 LLP  A 353 ( 3.8A)
LLP  A 353 ( 4.2A)
LLP  A 353 ( 4.0A)
LLP  A 353 (-3.6A)
 1.04A 5nnwD-4q6rA:
undetectable		 5nnwD-4q6rA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NO9_D_95ZD302_1
(25 KDA PROTEIN
ELICITOR)		 4q6r SPHINGOSINE-1-PHOSPH
ATE LYASE 1
(Homo
sapiens) 		4 / 7 ASP A 350
GLY A 209
HIS A 352
HIS A 242
 LLP  A 353 ( 3.8A)
LLP  A 353 ( 4.2A)
LLP  A 353 ( 4.0A)
LLP  A 353 (-3.6A)
 1.00A 5no9D-4q6rA:
undetectable		 5no9D-4q6rA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_G_ACTG702_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 4q6r SPHINGOSINE-1-PHOSPH
ATE LYASE 1
(Homo
sapiens) 		3 / 3 GLY A 521
THR A 519
ASN A 465
 None
GOL  A 902 (-4.5A)
GOL  A 902 (-4.3A)
 0.65A 5odiG-4q6rA:
undetectable		 5odiG-4q6rA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2S_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 4q6r SPHINGOSINE-1-PHOSPH
ATE LYASE 1
(Homo
sapiens) 		4 / 8 PRO A 311
THR A 345
TYR A 371
PRO A 238
 None
 1.21A 5x2sI-4q6rA:
undetectable
5x2sJ-4q6rA:
undetectable
5x2sK-4q6rA:
undetectable		 5x2sI-4q6rA:
14.65
5x2sJ-4q6rA:
14.48
5x2sK-4q6rA:
14.65