SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4q6t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_B_ID2B2_0
(THYMIDINE KINASE)		 4q6t GLYCOSYL HYDROLASE,
FAMILY 18
(Pseudomonas
protegens) 		5 / 12 GLU A  80
ILE A  86
GLN A  75
MET A  78
ARG A  87
 None
 1.08A 1ki7B-4q6tA:
undetectable		 1ki7B-4q6tA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_A_URFA999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 4q6t GLYCOSYL HYDROLASE,
FAMILY 18
(Pseudomonas
protegens) 		4 / 5 ALA A 136
TYR A  97
ILE A 144
ASP A 206
 None
 1.02A 1upfA-4q6tA:
undetectable		 1upfA-4q6tA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4q6t GLYCOSYL HYDROLASE,
FAMILY 18
(Pseudomonas
protegens) 		4 / 5 PHE A 162
LEU A 132
PHE A 159
SER A 180
 None
 1.23A 1wrkB-4q6tA:
undetectable		 1wrkB-4q6tA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1433_1
(CHITINASE)		 4q6t GLYCOSYL HYDROLASE,
FAMILY 18
(Pseudomonas
protegens) 		7 / 11 TYR A  37
GLU A 149
MET A 211
TYR A 213
ASP A 214
TYR A 263
TRP A 349
 None
 0.67A 2a3aA-4q6tA:
30.7		 2a3aA-4q6tA:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_B_TEPB2433_1
(CHITINASE)		 4q6t GLYCOSYL HYDROLASE,
FAMILY 18
(Pseudomonas
protegens) 		6 / 9 GLU A 149
MET A 211
TYR A 213
ASP A 214
TYR A 263
TRP A 349
 None
 0.61A 2a3aB-4q6tA:
31.1		 2a3aB-4q6tA:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_B_CFFB2435_1
(CHITINASE)		 4q6t GLYCOSYL HYDROLASE,
FAMILY 18
(Pseudomonas
protegens) 		6 / 10 ASP A 147
MET A 211
TYR A 213
ASP A 214
TYR A 263
TRP A 349
 None
 0.97A 2a3bB-4q6tA:
30.8		 2a3bB-4q6tA:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2433_1
(CHITINASE)		 4q6t GLYCOSYL HYDROLASE,
FAMILY 18
(Pseudomonas
protegens) 		6 / 12 ASP A 147
MET A 211
TYR A 213
ASP A 214
TYR A 263
TRP A 349
 None
 0.97A 2a3cB-4q6tA:
30.8		 2a3cB-4q6tA:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4q6t GLYCOSYL HYDROLASE,
FAMILY 18
(Pseudomonas
protegens) 		5 / 12 LEU A 132
LEU A  67
ILE A 114
ALA A 158
PHE A 148
 None
 0.91A 2h42C-4q6tA:
undetectable		 2h42C-4q6tA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_1
(ESTROGEN RECEPTOR)		 4q6t GLYCOSYL HYDROLASE,
FAMILY 18
(Pseudomonas
protegens) 		5 / 12 ALA A  89
LEU A  49
MET A  78
GLY A  62
LEU A  61
 None
 1.09A 2jfaB-4q6tA:
undetectable		 2jfaB-4q6tA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6K_A_ADNA699_1
(CHLORINASE)		 4q6t GLYCOSYL HYDROLASE,
FAMILY 18
(Pseudomonas
protegens) 		4 / 7 ASP A 214
TYR A 213
THR A 262
TRP A 349
 None
 1.40A 2q6kA-4q6tA:
undetectable		 2q6kA-4q6tA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UVN_B_ECNB1406_1
(CYTOCHROME P450 130)		 4q6t GLYCOSYL HYDROLASE,
FAMILY 18
(Pseudomonas
protegens) 		6 / 11 PRO A  98
THR A  64
GLY A  62
THR A  38
LEU A  96
TYR A  97
 None
 1.48A 2uvnB-4q6tA:
undetectable		 2uvnB-4q6tA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UY4_A_AZMA1311_1
(ENDOCHITINASE)		 4q6t GLYCOSYL HYDROLASE,
FAMILY 18
(Pseudomonas
protegens) 		5 / 9 TYR A  37
ASP A 147
GLU A 149
TYR A 213
TRP A 349
 None
 0.72A 2uy4A-4q6tA:
16.1		 2uy4A-4q6tA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_E_GCSE710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 4q6t GLYCOSYL HYDROLASE,
FAMILY 18
(Pseudomonas
protegens) 		4 / 8 ASP A 266
SER A 268
ILE A 269
HIS A 285
 NI  A 402 ( 4.5A)
NI  A 402 ( 4.2A)
None
NI  A 402 (-3.2A)
 0.83A 2xadA-4q6tA:
undetectable		 2xadA-4q6tA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_F_GCSF710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 4q6t GLYCOSYL HYDROLASE,
FAMILY 18
(Pseudomonas
protegens) 		4 / 8 ASP A 266
SER A 268
ILE A 269
HIS A 285
 NI  A 402 ( 4.5A)
NI  A 402 ( 4.2A)
None
NI  A 402 (-3.2A)
 0.81A 2xadB-4q6tA:
undetectable		 2xadB-4q6tA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_G_GCSG710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 4q6t GLYCOSYL HYDROLASE,
FAMILY 18
(Pseudomonas
protegens) 		4 / 8 ASP A 266
SER A 268
ILE A 269
HIS A 285
 NI  A 402 ( 4.5A)
NI  A 402 ( 4.2A)
None
NI  A 402 (-3.2A)
 0.82A 2xadC-4q6tA:
2.1		 2xadC-4q6tA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_H_GCSH710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 4q6t GLYCOSYL HYDROLASE,
FAMILY 18
(Pseudomonas
protegens) 		4 / 8 ASP A 266
SER A 268
ILE A 269
HIS A 285
 NI  A 402 ( 4.5A)
NI  A 402 ( 4.2A)
None
NI  A 402 (-3.2A)
 0.83A 2xadD-4q6tA:
undetectable		 2xadD-4q6tA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_2
(RENIN)		 4q6t GLYCOSYL HYDROLASE,
FAMILY 18
(Pseudomonas
protegens) 		4 / 4 VAL A 251
TYR A 246
PRO A 183
PHE A 208
 None
 1.37A 3d91B-4q6tA:
undetectable		 3d91B-4q6tA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G6M_A_CFFA1_1
(CHITINASE)		 4q6t GLYCOSYL HYDROLASE,
FAMILY 18
(Pseudomonas
protegens) 		7 / 11 TYR A  37
GLU A 149
MET A 211
TYR A 213
ASP A 214
TYR A 263
TRP A 349
 None
 0.74A 3g6mA-4q6tA:
30.9		 3g6mA-4q6tA:
26.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB201_1
(PROTEIN S100-A4)		 4q6t GLYCOSYL HYDROLASE,
FAMILY 18
(Pseudomonas
protegens) 		4 / 8 GLY A 259
ILE A 178
PHE A 148
PHE A 159
 None
 1.00A 3ko0B-4q6tA:
undetectable
3ko0J-4q6tA:
undetectable		 3ko0B-4q6tA:
13.24
3ko0J-4q6tA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK201_1
(PROTEIN S100-A4)		 4q6t GLYCOSYL HYDROLASE,
FAMILY 18
(Pseudomonas
protegens) 		4 / 8 GLY A 259
ILE A 178
PHE A 148
PHE A 159
 None
 1.00A 3ko0K-4q6tA:
undetectable
3ko0S-4q6tA:
undetectable		 3ko0K-4q6tA:
13.24
3ko0S-4q6tA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_A_NCAA192_0
(NICOTINAMIDASE)		 4q6t GLYCOSYL HYDROLASE,
FAMILY 18
(Pseudomonas
protegens) 		5 / 11 ASP A 102
LEU A 146
PHE A 162
LEU A  67
ILE A 118
 None
 1.26A 3o94A-4q6tA:
undetectable		 3o94A-4q6tA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_B_NCAB192_0
(NICOTINAMIDASE)		 4q6t GLYCOSYL HYDROLASE,
FAMILY 18
(Pseudomonas
protegens) 		5 / 11 ASP A 102
LEU A 146
PHE A 162
LEU A  67
ILE A 118
 None
 1.29A 3o94B-4q6tA:
undetectable		 3o94B-4q6tA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_C_NCAC192_0
(NICOTINAMIDASE)		 4q6t GLYCOSYL HYDROLASE,
FAMILY 18
(Pseudomonas
protegens) 		5 / 11 ASP A 102
LEU A 146
PHE A 162
LEU A  67
ILE A 118
 None
 1.28A 3o94C-4q6tA:
undetectable		 3o94C-4q6tA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_D_NCAD192_0
(NICOTINAMIDASE)		 4q6t GLYCOSYL HYDROLASE,
FAMILY 18
(Pseudomonas
protegens) 		5 / 11 ASP A 102
LEU A 146
PHE A 162
LEU A  67
ILE A 118
 None
 1.28A 3o94D-4q6tA:
undetectable		 3o94D-4q6tA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		 4q6t GLYCOSYL HYDROLASE,
FAMILY 18
(Pseudomonas
protegens) 		4 / 8 ASP A 238
PRO A 298
TYR A 299
PRO A 233
 None
 1.15A 3oyaA-4q6tA:
undetectable		 3oyaA-4q6tA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UWL_B_FOZB316_0
(THYMIDYLATE SYNTHASE)		 4q6t GLYCOSYL HYDROLASE,
FAMILY 18
(Pseudomonas
protegens) 		5 / 12 LEU A 260
ILE A 331
GLY A 357
PHE A 358
ASN A 355
 None
 1.01A 3uwlB-4q6tA:
undetectable		 3uwlB-4q6tA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQV_A_GCSA501_1
(CHITINASE)		 4q6t GLYCOSYL HYDROLASE,
FAMILY 18
(Pseudomonas
protegens) 		5 / 11 ASP A 147
GLU A 149
MET A 211
TYR A 213
ARG A 272
 None
 1.19A 3wqvA-4q6tA:
33.4		 3wqvA-4q6tA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQV_A_GCSA501_1
(CHITINASE)		 4q6t GLYCOSYL HYDROLASE,
FAMILY 18
(Pseudomonas
protegens) 		7 / 11 ASP A 147
GLU A 149
MET A 211
TYR A 213
ASP A 214
TYR A 263
TRP A 349
 None
 0.43A 3wqvA-4q6tA:
33.4		 3wqvA-4q6tA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQW_A_GCSA501_1
(CHITINASE)		 4q6t GLYCOSYL HYDROLASE,
FAMILY 18
(Pseudomonas
protegens) 		5 / 11 ASP A 147
GLU A 149
MET A 211
TYR A 213
ARG A 272
 None
 1.18A 3wqwA-4q6tA:
33.4		 3wqwA-4q6tA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQW_A_GCSA501_1
(CHITINASE)		 4q6t GLYCOSYL HYDROLASE,
FAMILY 18
(Pseudomonas
protegens) 		7 / 11 ASP A 147
GLU A 149
MET A 211
TYR A 213
ASP A 214
TYR A 263
TRP A 349
 None
 0.44A 3wqwA-4q6tA:
33.4		 3wqwA-4q6tA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9K_B_TYLB2198_1
(CREB-BINDING PROTEIN)		 4q6t GLYCOSYL HYDROLASE,
FAMILY 18
(Pseudomonas
protegens) 		4 / 5 VAL A 163
LEU A 146
ILE A 179
VAL A 151
 None
 0.86A 4a9kB-4q6tA:
undetectable		 4a9kB-4q6tA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEX_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4q6t GLYCOSYL HYDROLASE,
FAMILY 18
(Pseudomonas
protegens) 		4 / 7 ASP A 214
ASP A  39
GLU A 149
GLU A 234
 None
 1.23A 4fexB-4q6tA:
undetectable		 4fexB-4q6tA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_A_IMNA201_1
(TRANSTHYRETIN)		 4q6t GLYCOSYL HYDROLASE,
FAMILY 18
(Pseudomonas
protegens) 		4 / 7 MET A  78
LEU A  96
THR A  64
THR A  99
 None
 0.99A 4ik7A-4q6tA:
undetectable		 4ik7A-4q6tA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_A_ADNA401_2
(ADENOSINE KINASE)		 4q6t GLYCOSYL HYDROLASE,
FAMILY 18
(Pseudomonas
protegens) 		4 / 4 LEU A 362
SER A 347
LEU A  56
LEU A 366
 None
 1.09A 4n09A-4q6tA:
undetectable		 4n09A-4q6tA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB301_1
(CHITOSANASE)		 4q6t GLYCOSYL HYDROLASE,
FAMILY 18
(Pseudomonas
protegens) 		3 / 3 GLY A 303
PRO A 304
GLN A 320
 None
 0.51A 4oltB-4q6tA:
undetectable		 4oltB-4q6tA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_A_SAMA301_0
(PUTATIVE RNA
METHYLASE)		 4q6t GLYCOSYL HYDROLASE,
FAMILY 18
(Pseudomonas
protegens) 		5 / 12 THR A  68
GLY A  66
ILE A 118
SER A 117
LEU A  73
 None
 1.34A 4pooA-4q6tA:
undetectable		 4pooA-4q6tA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB305_1
(CHITOSANASE)		 4q6t GLYCOSYL HYDROLASE,
FAMILY 18
(Pseudomonas
protegens) 		3 / 3 GLY A 303
PRO A 304
GLN A 320
 None
 0.53A 4qwpB-4q6tA:
undetectable		 4qwpB-4q6tA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA603_1
(CHITINASE)		 4q6t GLYCOSYL HYDROLASE,
FAMILY 18
(Pseudomonas
protegens) 		4 / 8 GLU A 149
TYR A 213
ASP A 214
TRP A 349
 None
 0.46A 5gqbA-4q6tA:
31.1		 5gqbA-4q6tA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 4q6t GLYCOSYL HYDROLASE,
FAMILY 18
(Pseudomonas
protegens) 		4 / 5 GLY A  40
THR A  64
GLN A  83
THR A  81
 None
 1.16A 5h5fA-4q6tA:
undetectable		 5h5fA-4q6tA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JDC_D_6JPD302_1
(PTERIDINE REDUCTASE)		 4q6t GLYCOSYL HYDROLASE,
FAMILY 18
(Pseudomonas
protegens) 		5 / 11 SER A 180
MET A 351
VAL A  59
LEU A  96
PRO A  98
 None
 1.40A 5jdcA-4q6tA:
4.1
5jdcD-4q6tA:
2.6		 5jdcA-4q6tA:
20.28
5jdcD-4q6tA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_H_CHDH401_0
(BILE SALT HYDROLASE)		 4q6t GLYCOSYL HYDROLASE,
FAMILY 18
(Pseudomonas
protegens) 		5 / 10 LEU A 193
LEU A 119
PHE A 162
LEU A 146
LEU A 201
 None
 1.22A 5y7pH-4q6tA:
undetectable		 5y7pH-4q6tA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_B_FOZB403_0
(THYMIDYLATE SYNTHASE)		 4q6t GLYCOSYL HYDROLASE,
FAMILY 18
(Pseudomonas
protegens) 		5 / 12 LEU A 260
ILE A 331
GLY A 357
PHE A 358
ASN A 355
 None
 0.98A 6qxsB-4q6tA:
undetectable		 6qxsB-4q6tA:
21.62