SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4q6x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 4q6x PHOSPHOLIPASE D
STSICTOX-BETAIC1
(Sicarius
terrosus) 		4 / 5 LEU A 257
PRO A 250
VAL A 253
ILE A 254
 None
 0.97A 2aoiB-4q6xA:
undetectable		 2aoiB-4q6xA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_B_SAMB302_0
(YCGJ)		 4q6x PHOSPHOLIPASE D
STSICTOX-BETAIC1
(Sicarius
terrosus) 		5 / 12 GLY A 106
GLY A 144
THR A  41
ALA A  42
ALA A 110
 None
 0.92A 2gluB-4q6xA:
undetectable		 2gluB-4q6xA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 4q6x PHOSPHOLIPASE D
STSICTOX-BETAIC1
(Sicarius
terrosus) 		5 / 12 PHE A 166
PHE A 145
ALA A 107
ALA A 102
ALA A 110
 None
 1.23A 2igtC-4q6xA:
2.2		 2igtC-4q6xA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_D_LOCD700_2
(TUBULIN BETA-2B
CHAIN)		 4q6x PHOSPHOLIPASE D
STSICTOX-BETAIC1
(Sicarius
terrosus) 		5 / 11 LEU A 131
LEU A  94
ASN A 104
ALA A  42
VAL A  34
 None
 1.24A 3e22D-4q6xA:
undetectable		 3e22D-4q6xA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_D_TPFD490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 4q6x PHOSPHOLIPASE D
STSICTOX-BETAIC1
(Sicarius
terrosus) 		4 / 8 PHE A 141
ALA A 105
ALA A  42
LEU A  67
 None
 1.07A 3l4dD-4q6xA:
undetectable		 3l4dD-4q6xA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_3
(NS3 PROTEASE, NS4A
PROTEIN)		 4q6x PHOSPHOLIPASE D
STSICTOX-BETAIC1
(Sicarius
terrosus) 		4 / 5 SER A 227
PRO A 250
TYR A  22
VAL A 253
 None
 1.34A 3sufC-4q6xA:
undetectable		 3sufC-4q6xA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_3
(NS3 PROTEASE, NS4A
PROTEIN)		 4q6x PHOSPHOLIPASE D
STSICTOX-BETAIC1
(Sicarius
terrosus) 		4 / 5 SER A 227
PRO A 250
TYR A 249
VAL A 253
 None
 1.35A 3sufC-4q6xA:
undetectable		 3sufC-4q6xA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4q6x PHOSPHOLIPASE D
STSICTOX-BETAIC1
(Sicarius
terrosus) 		4 / 7 LEU A  67
LYS A  65
GLN A  72
LEU A  73
 None
 1.11A 4ib4A-4q6xA:
undetectable		 4ib4A-4q6xA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_A_STRA601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 4q6x PHOSPHOLIPASE D
STSICTOX-BETAIC1
(Sicarius
terrosus) 		4 / 6 ALA A 269
GLY A 244
ILE A  86
VAL A  89
 None
 0.68A 4r21A-4q6xA:
undetectable		 4r21A-4q6xA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_2
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 4q6x PHOSPHOLIPASE D
STSICTOX-BETAIC1
(Sicarius
terrosus) 		4 / 4 VAL A 242
ILE A 228
ASN A   8
VAL A 256
 None
 1.34A 5ajqA-4q6xA:
undetectable		 5ajqA-4q6xA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 4q6x PHOSPHOLIPASE D
STSICTOX-BETAIC1
(Sicarius
terrosus) 		4 / 7 LEU A 131
VAL A  89
GLU A  31
ILE A 175
 None
None
MG  A 301 (-2.6A)
None
 1.13A 5jh7C-4q6xA:
undetectable		 5jh7C-4q6xA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_D_BZMD301_0
(ISATIN HYDROLASE A)		 4q6x PHOSPHOLIPASE D
STSICTOX-BETAIC1
(Sicarius
terrosus) 		5 / 12 LEU A 257
VAL A 245
GLY A 244
ASP A 243
GLY A 241
 None
 1.19A 5nnaD-4q6xA:
undetectable		 5nnaD-4q6xA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYB_A_KKKA508_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 4q6x PHOSPHOLIPASE D
STSICTOX-BETAIC1
(Sicarius
terrosus) 		5 / 12 PHE A 141
ALA A 105
ALA A  42
LEU A  67
ILE A  70
 None
 1.14A 6aybA-4q6xA:
undetectable		 6aybA-4q6xA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_B_AM2B301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4q6x PHOSPHOLIPASE D
STSICTOX-BETAIC1
(Sicarius
terrosus) 		4 / 8 HIS A  11
GLU A  31
ASP A  91
GLU A 134
 None
MG  A 301 (-2.6A)
MG  A 301 (-3.1A)
None
 1.01A 6mn4B-4q6xA:
undetectable		 6mn4B-4q6xA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_D_AM2D301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4q6x PHOSPHOLIPASE D
STSICTOX-BETAIC1
(Sicarius
terrosus) 		4 / 8 HIS A  11
GLU A  31
ASP A  91
GLU A 134
 None
MG  A 301 (-2.6A)
MG  A 301 (-3.1A)
None
 1.03A 6mn4D-4q6xA:
undetectable		 6mn4D-4q6xA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_F_AM2F301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4q6x PHOSPHOLIPASE D
STSICTOX-BETAIC1
(Sicarius
terrosus) 		4 / 7 HIS A  11
GLU A  31
ASP A  91
GLU A 134
 None
MG  A 301 (-2.6A)
MG  A 301 (-3.1A)
None
 1.19A 6mn4F-4q6xA:
undetectable		 6mn4F-4q6xA:
22.68