SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4q73'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_A_DVAA6_0
(GRAMICIDIN A)		 4q73 PROLINE
DEHYDROGENASE
(Bradyrhizobium
diazoefficiens) 		3 / 3 ALA A 313
VAL A 363
TRP A 346
 None
None
FAD  A2001 (-3.6A)
 0.82A 1av2A-4q73A:
undetectable
1av2B-4q73A:
undetectable		 1av2A-4q73A:
2.58
1av2B-4q73A:
2.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD6_0
(GRAMICIDIN A)		 4q73 PROLINE
DEHYDROGENASE
(Bradyrhizobium
diazoefficiens) 		3 / 3 TRP A 346
ALA A 313
VAL A 363
 FAD  A2001 (-3.6A)
None
None
 0.91A 1av2C-4q73A:
undetectable
1av2D-4q73A:
undetectable		 1av2C-4q73A:
2.58
1av2D-4q73A:
2.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4q73 PROLINE
DEHYDROGENASE
(Bradyrhizobium
diazoefficiens) 		5 / 10 THR A 770
ALA A 771
LEU A 900
VAL A 903
ILE A 929
 None
 1.23A 1claA-4q73A:
undetectable		 1claA-4q73A:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_1
(VITAMIN D NUCLEAR
RECEPTOR)		 4q73 PROLINE
DEHYDROGENASE
(Bradyrhizobium
diazoefficiens) 		5 / 12 LEU A 904
LEU A 900
VAL A 903
SER A 920
VAL A 933
 None
 1.28A 1db1A-4q73A:
undetectable		 1db1A-4q73A:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GWR_A_ESTA600_1
(OESTROGEN RECEPTOR)		 4q73 PROLINE
DEHYDROGENASE
(Bradyrhizobium
diazoefficiens) 		5 / 10 LEU A 328
ALA A 329
LEU A 336
LEU A 309
LEU A 384
 None
 1.10A 1gwrA-4q73A:
undetectable		 1gwrA-4q73A:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE9_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 4q73 PROLINE
DEHYDROGENASE
(Bradyrhizobium
diazoefficiens) 		5 / 12 LEU A 904
LEU A 900
VAL A 903
SER A 920
VAL A 933
 None
 1.32A 1ie9A-4q73A:
undetectable		 1ie9A-4q73A:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K6C_B_MK1B902_1
(POL POLYPROTEIN)		 4q73 PROLINE
DEHYDROGENASE
(Bradyrhizobium
diazoefficiens) 		5 / 10 ARG A 244
ALA A 869
ILE A 889
GLY A 887
GLY A 789
 None
 1.04A 1k6cA-4q73A:
undetectable		 1k6cA-4q73A:
7.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_B_ACTB704_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 4q73 PROLINE
DEHYDROGENASE
(Bradyrhizobium
diazoefficiens) 		3 / 3 ARG A 207
GLY A 196
ASP A 449
 None
 0.50A 1kf6A-4q73A:
undetectable
1kf6B-4q73A:
undetectable		 1kf6A-4q73A:
20.75
1kf6B-4q73A:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L8T_A_KANA1_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E)		 4q73 PROLINE
DEHYDROGENASE
(Bradyrhizobium
diazoefficiens) 		5 / 10 ASN A 274
ASP A 193
ARG A 339
GLU A 414
ASP A 278
 None
None
FAD  A2001 (-4.0A)
None
FAD  A2001 (-3.7A)
 1.29A 1l8tA-4q73A:
0.0		 1l8tA-4q73A:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1868_0
(FPRA)		 4q73 PROLINE
DEHYDROGENASE
(Bradyrhizobium
diazoefficiens) 		3 / 3 ALA A 550
HIS A 551
VAL A 554
 None
 0.52A 1lqtB-4q73A:
undetectable		 1lqtB-4q73A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1425_0
(FPRA)		 4q73 PROLINE
DEHYDROGENASE
(Bradyrhizobium
diazoefficiens) 		3 / 3 ALA A 550
HIS A 551
VAL A 554
 None
 0.51A 1lquB-4q73A:
undetectable		 1lquB-4q73A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_E_BEZE509_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4q73 PROLINE
DEHYDROGENASE
(Bradyrhizobium
diazoefficiens) 		5 / 7 ILE A 821
PRO A 870
PHE A 858
ARG A 817
ALA A 816
 None
 1.43A 1oniD-4q73A:
undetectable
1oniE-4q73A:
undetectable		 1oniD-4q73A:
10.72
1oniE-4q73A:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_H_BEZH515_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4q73 PROLINE
DEHYDROGENASE
(Bradyrhizobium
diazoefficiens) 		4 / 6 PHE A 858
ALA A 816
ILE A 821
PRO A 870
 None
 1.08A 1oniH-4q73A:
0.3
1oniI-4q73A:
undetectable		 1oniH-4q73A:
10.72
1oniI-4q73A:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI518_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4q73 PROLINE
DEHYDROGENASE
(Bradyrhizobium
diazoefficiens) 		4 / 7 GLY A 647
PRO A 754
PHE A 651
ASN A 676
 None
 0.95A 1oniG-4q73A:
undetectable
1oniI-4q73A:
undetectable		 1oniG-4q73A:
10.72
1oniI-4q73A:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_H_FUAH709_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4q73 PROLINE
DEHYDROGENASE
(Bradyrhizobium
diazoefficiens) 		5 / 12 LEU A 709
PHE A 664
VAL A 694
VAL A 730
ALA A 653
 None
 1.16A 1q23H-4q73A:
undetectable
1q23I-4q73A:
undetectable		 1q23H-4q73A:
11.97
1q23I-4q73A:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_A_SAMA501_0
(BIOTIN SYNTHASE)		 4q73 PROLINE
DEHYDROGENASE
(Bradyrhizobium
diazoefficiens) 		5 / 12 GLY A 520
ASP A 290
ARG A 250
LEU A 328
VAL A 325
 None
 1.18A 1r30A-4q73A:
9.4		 1r30A-4q73A:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TJ2_A_ACTA2002_0
(BIFUNCTIONAL PUTA
PROTEIN)		 4q73 PROLINE
DEHYDROGENASE
(Bradyrhizobium
diazoefficiens) 		4 / 5 LYS A 237
ALA A 344
TYR A 453
ARG A 456
 None
FAD  A2001 (-3.6A)
None
None
 0.54A 1tj2A-4q73A:
46.0		 1tj2A-4q73A:
28.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_A_DVAA6_0
(GRAMICIDIN D)		 4q73 PROLINE
DEHYDROGENASE
(Bradyrhizobium
diazoefficiens) 		3 / 3 ALA A 313
VAL A 363
TRP A 346
 None
None
FAD  A2001 (-3.6A)
 0.86A 1w5uA-4q73A:
undetectable
1w5uB-4q73A:
undetectable		 1w5uA-4q73A:
2.58
1w5uB-4q73A:
2.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB6_0
(GRAMICIDIN D)		 4q73 PROLINE
DEHYDROGENASE
(Bradyrhizobium
diazoefficiens) 		3 / 3 TRP A 346
ALA A 313
VAL A 363
 FAD  A2001 (-3.6A)
None
None
 0.82A 1w5uA-4q73A:
undetectable
1w5uB-4q73A:
undetectable		 1w5uA-4q73A:
2.58
1w5uB-4q73A:
2.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		 4q73 PROLINE
DEHYDROGENASE
(Bradyrhizobium
diazoefficiens) 		4 / 4 LEU A 309
PRO A 229
ILE A 388
LEU A 336
 None
 1.16A 1ya4C-4q73A:
undetectable		 1ya4C-4q73A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_B_SAMB500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 4q73 PROLINE
DEHYDROGENASE
(Bradyrhizobium
diazoefficiens) 		5 / 11 VAL A 152
THR A 154
GLU A  96
ILE A 130
PHE A  94
 None
 1.29A 2admB-4q73A:
undetectable		 2admB-4q73A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_B_IBPB2002_1
(SERUM ALBUMIN)		 4q73 PROLINE
DEHYDROGENASE
(Bradyrhizobium
diazoefficiens) 		5 / 10 ALA A 690
ALA A 693
LEU A 583
LEU A 665
ALA A 612
 None
 0.89A 2bxgB-4q73A:
undetectable		 2bxgB-4q73A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA6_0
(GRAMICIDIN D)		 4q73 PROLINE
DEHYDROGENASE
(Bradyrhizobium
diazoefficiens) 		3 / 3 ALA A 313
VAL A 363
TRP A 346
 None
None
FAD  A2001 (-3.6A)
 0.96A 2izqA-4q73A:
undetectable
2izqB-4q73A:
undetectable		 2izqA-4q73A:
2.58
2izqB-4q73A:
2.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_D_DVAD6_0
(GRAMICIDIN D)		 4q73 PROLINE
DEHYDROGENASE
(Bradyrhizobium
diazoefficiens) 		3 / 3 TRP A 346
ALA A 313
VAL A 363
 FAD  A2001 (-3.6A)
None
None
 0.88A 2izqC-4q73A:
undetectable
2izqD-4q73A:
undetectable		 2izqC-4q73A:
2.58
2izqD-4q73A:
2.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB501_1
(CYTOCHROME P450 2C8)		 4q73 PROLINE
DEHYDROGENASE
(Bradyrhizobium
diazoefficiens) 		5 / 9 SER A 960
ILE A 938
VAL A 933
ILE A 907
VAL A 903
 None
 1.35A 2nnhB-4q73A:
undetectable		 2nnhB-4q73A:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_A_SAMA201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 4q73 PROLINE
DEHYDROGENASE
(Bradyrhizobium
diazoefficiens) 		5 / 12 GLY A 675
ALA A 674
LEU A 707
VAL A 554
LEU A 720
 None
 1.03A 2nyuA-4q73A:
4.8		 2nyuA-4q73A:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_B_MXDB551_1
(PROSTACYCLIN
SYNTHASE)		 4q73 PROLINE
DEHYDROGENASE
(Bradyrhizobium
diazoefficiens) 		4 / 6 ALA A  66
LEU A  67
ALA A 155
THR A 154
 None
 0.92A 3b6hB-4q73A:
undetectable		 3b6hB-4q73A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_A_PAUA248_0
(TYPE III
PANTOTHENATE KINASE)		 4q73 PROLINE
DEHYDROGENASE
(Bradyrhizobium
diazoefficiens) 		5 / 11 VAL A 168
GLY A 180
THR A 188
ILE A 219
THR A 218
 None
 1.24A 3bf1A-4q73A:
1.3
3bf1B-4q73A:
undetectable		 3bf1A-4q73A:
14.64
3bf1B-4q73A:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 4q73 PROLINE
DEHYDROGENASE
(Bradyrhizobium
diazoefficiens) 		5 / 11 VAL A 168
GLY A 180
THR A 188
ILE A 219
THR A 218
 None
 1.23A 3bf1C-4q73A:
undetectable
3bf1D-4q73A:
undetectable		 3bf1C-4q73A:
14.64
3bf1D-4q73A:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_E_PAUE248_0
(TYPE III
PANTOTHENATE KINASE)		 4q73 PROLINE
DEHYDROGENASE
(Bradyrhizobium
diazoefficiens) 		5 / 11 VAL A 168
GLY A 180
THR A 188
ILE A 219
THR A 218
 None
 1.27A 3bf1E-4q73A:
undetectable
3bf1F-4q73A:
undetectable		 3bf1E-4q73A:
14.64
3bf1F-4q73A:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_B_SALB258_1
(TRANSCRIPTIONAL
REGULATOR)		 4q73 PROLINE
DEHYDROGENASE
(Bradyrhizobium
diazoefficiens) 		5 / 11 ALA A 282
LEU A 285
ARG A 284
GLY A 520
ARG A 356
 None
None
None
None
GOL  A2007 (-3.7A)
 1.29A 3bpxA-4q73A:
undetectable
3bpxB-4q73A:
undetectable		 3bpxA-4q73A:
9.29
3bpxB-4q73A:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_2
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 4q73 PROLINE
DEHYDROGENASE
(Bradyrhizobium
diazoefficiens) 		4 / 4 VAL A 403
ARG A 339
ILE A 322
THR A 399
 None
FAD  A2001 (-4.0A)
None
FAD  A2001 ( 4.6A)
 1.30A 3cl9A-4q73A:
2.5		 3cl9A-4q73A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_B_SAMB300_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 4q73 PROLINE
DEHYDROGENASE
(Bradyrhizobium
diazoefficiens) 		5 / 12 PHE A 954
LEU A 914
GLY A 963
GLY A 956
ALA A 757
 SO4  A2002 ( 4.3A)
None
None
None
None
 0.96A 3dh0B-4q73A:
5.3		 3dh0B-4q73A:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4q73 PROLINE
DEHYDROGENASE
(Bradyrhizobium
diazoefficiens) 		6 / 12 ILE A 292
SER A 235
ARG A 339
LEU A 309
ALA A 310
LEU A 257
 None
None
FAD  A2001 (-4.0A)
None
FAD  A2001 (-3.5A)
None
 1.40A 3dzyA-4q73A:
undetectable		 3dzyA-4q73A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_1
(UNCHARACTERIZED
PROTEIN)		 4q73 PROLINE
DEHYDROGENASE
(Bradyrhizobium
diazoefficiens) 		3 / 3 THR A 876
LYS A 110
GLU A 874
 None
 0.87A 3ijdB-4q73A:
2.6		 3ijdB-4q73A:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD6_0
(GRAMICIDIN D)		 4q73 PROLINE
DEHYDROGENASE
(Bradyrhizobium
diazoefficiens) 		3 / 3 TRP A 346
ALA A 313
VAL A 363
 FAD  A2001 (-3.6A)
None
None
 0.85A 3l8lC-4q73A:
undetectable
3l8lD-4q73A:
undetectable		 3l8lC-4q73A:
2.58
3l8lD-4q73A:
2.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_1
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 4q73 PROLINE
DEHYDROGENASE
(Bradyrhizobium
diazoefficiens) 		3 / 3 ARG A 200
ASP A 283
GLN A 312
 None
None
FAD  A2001 (-3.6A)
 0.79A 3lcvB-4q73A:
2.7		 3lcvB-4q73A:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4q73 PROLINE
DEHYDROGENASE
(Bradyrhizobium
diazoefficiens) 		4 / 7 ARG A 617
SER A 585
LEU A 665
PHE A 590
 None
SO4  A2005 (-3.0A)
None
None
 1.01A 3ln1C-4q73A:
1.0		 3ln1C-4q73A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_B_CL6B506_1
(CHOLESTEROL
24-HYDROXYLASE)		 4q73 PROLINE
DEHYDROGENASE
(Bradyrhizobium
diazoefficiens) 		6 / 12 LEU A  67
THR A 139
ILE A 140
ALA A  79
ALA A 155
THR A 156
 None
 1.44A 3mdvB-4q73A:
undetectable		 3mdvB-4q73A:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIH_A_CUA358_0
(PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE)		 4q73 PROLINE
DEHYDROGENASE
(Bradyrhizobium
diazoefficiens) 		3 / 3 HIS A 891
HIS A 846
MET A 850
 None
 1.02A 3mihA-4q73A:
undetectable		 3mihA-4q73A:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_2
(PROTEASE)		 4q73 PROLINE
DEHYDROGENASE
(Bradyrhizobium
diazoefficiens) 		4 / 6 ILE A 591
PRO A 824
ILE A 835
GLY A 598
 None
 0.98A 3n3iA-4q73A:
undetectable		 3n3iA-4q73A:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_A_SALA404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 4q73 PROLINE
DEHYDROGENASE
(Bradyrhizobium
diazoefficiens) 		4 / 7 ALA A 579
ARG A 511
ALA A 620
ARG A 624
 None
None
None
SO4  A2003 (-4.8A)
 1.12A 3twpA-4q73A:
3.5		 3twpA-4q73A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_B_CLMB221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4q73 PROLINE
DEHYDROGENASE
(Bradyrhizobium
diazoefficiens) 		5 / 12 THR A 910
LEU A 916
VAL A 918
VAL A 933
PHE A 799
 None
 1.34A 3u9fB-4q73A:
undetectable
3u9fC-4q73A:
undetectable		 3u9fB-4q73A:
11.97
3u9fC-4q73A:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_B_CLMB221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4q73 PROLINE
DEHYDROGENASE
(Bradyrhizobium
diazoefficiens) 		5 / 12 THR A 910
LEU A 916
VAL A 918
VAL A 935
PHE A 799
 None
 1.28A 3u9fB-4q73A:
undetectable
3u9fC-4q73A:
undetectable		 3u9fB-4q73A:
11.97
3u9fC-4q73A:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_H_CLMH221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4q73 PROLINE
DEHYDROGENASE
(Bradyrhizobium
diazoefficiens) 		5 / 12 THR A 910
LEU A 916
VAL A 918
VAL A 933
PHE A 799
 None
 1.33A 3u9fH-4q73A:
undetectable
3u9fI-4q73A:
undetectable		 3u9fH-4q73A:
11.97
3u9fI-4q73A:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_N_CLMN221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4q73 PROLINE
DEHYDROGENASE
(Bradyrhizobium
diazoefficiens) 		5 / 11 THR A 910
LEU A 916
VAL A 918
VAL A 933
PHE A 799
 None
 1.36A 3u9fN-4q73A:
undetectable
3u9fO-4q73A:
undetectable		 3u9fN-4q73A:
11.97
3u9fO-4q73A:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_S_CLMS221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4q73 PROLINE
DEHYDROGENASE
(Bradyrhizobium
diazoefficiens) 		5 / 12 PHE A 799
THR A 910
LEU A 916
VAL A 918
VAL A 933
 None
 1.34A 3u9fP-4q73A:
undetectable
3u9fS-4q73A:
undetectable		 3u9fP-4q73A:
11.97
3u9fS-4q73A:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_S_CLMS221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4q73 PROLINE
DEHYDROGENASE
(Bradyrhizobium
diazoefficiens) 		5 / 12 PHE A 799
THR A 910
LEU A 916
VAL A 918
VAL A 935
 None
 1.27A 3u9fP-4q73A:
undetectable
3u9fS-4q73A:
undetectable		 3u9fP-4q73A:
11.97
3u9fS-4q73A:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_B_ADNB401_2
(PUTATIVE ADENOSINE
KINASE)		 4q73 PROLINE
DEHYDROGENASE
(Bradyrhizobium
diazoefficiens) 		4 / 5 LEU A 301
ALA A 268
THR A 295
PHE A 275
 None
 1.19A 3vasB-4q73A:
undetectable		 3vasB-4q73A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9K_B_TYLB2198_1
(CREB-BINDING PROTEIN)		 4q73 PROLINE
DEHYDROGENASE
(Bradyrhizobium
diazoefficiens) 		4 / 5 VAL A 933
LEU A 904
ILE A 907
VAL A 918
 None
 0.83A 4a9kB-4q73A:
undetectable		 4a9kB-4q73A:
7.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQ7_A_LEUA902_0
(LEUCINE--TRNA LIGASE)		 4q73 PROLINE
DEHYDROGENASE
(Bradyrhizobium
diazoefficiens) 		4 / 7 MET A 194
LEU A 195
ASP A 449
SER A 446
 None
 1.04A 4aq7A-4q73A:
undetectable		 4aq7A-4q73A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4q73 PROLINE
DEHYDROGENASE
(Bradyrhizobium
diazoefficiens) 		4 / 8 ILE A 889
ARG A 796
PRO A 863
VAL A 831
 None
 1.33A 4f4dB-4q73A:
2.7		 4f4dB-4q73A:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4q73 PROLINE
DEHYDROGENASE
(Bradyrhizobium
diazoefficiens) 		4 / 8 GLY A 133
GLY A 102
GLU A 101
VAL A 144
 None
 0.91A 4fgzB-4q73A:
4.6		 4fgzB-4q73A:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_A_STRA301_1
(STEROID RECEPTOR 2)		 4q73 PROLINE
DEHYDROGENASE
(Bradyrhizobium
diazoefficiens) 		5 / 12 LEU A 606
LEU A 609
LEU A 661
ALA A 662
ALA A 580
 None
 1.07A 4fn9A-4q73A:
undetectable		 4fn9A-4q73A:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_1
(METHYLTRANSFERASE
NSUN4)		 4q73 PROLINE
DEHYDROGENASE
(Bradyrhizobium
diazoefficiens) 		3 / 3 ASP A 263
ARG A 267
ASP A 298
 None
 0.82A 4fp9A-4q73A:
4.0		 4fp9A-4q73A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_ACTA303_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 4q73 PROLINE
DEHYDROGENASE
(Bradyrhizobium
diazoefficiens) 		3 / 3 TYR A 778
HIS A 830
ARG A 244
 None
 0.99A 4htfA-4q73A:
4.2		 4htfA-4q73A:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA501_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4q73 PROLINE
DEHYDROGENASE
(Bradyrhizobium
diazoefficiens) 		5 / 12 ASP A 768
VAL A 940
ASP A 923
ILE A 926
ARG A 142
 None
 1.37A 4i41A-4q73A:
0.2		 4i41A-4q73A:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		 4q73 PROLINE
DEHYDROGENASE
(Bradyrhizobium
diazoefficiens) 		6 / 12 LEU A 916
VAL A 918
GLN A 801
ILE A 766
ILE A 907
ALA A 906
 None
 1.30A 4ltwA-4q73A:
undetectable		 4ltwA-4q73A:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4q73 PROLINE
DEHYDROGENASE
(Bradyrhizobium
diazoefficiens) 		4 / 6 VAL A 455
LEU A  73
LEU A 772
MET A 194
 None
 1.06A 4o1zA-4q73A:
undetectable		 4o1zA-4q73A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB301_1
(CHITOSANASE)		 4q73 PROLINE
DEHYDROGENASE
(Bradyrhizobium
diazoefficiens) 		3 / 3 GLY A 832
PRO A 833
GLN A 790
 None
 0.35A 4oltB-4q73A:
undetectable		 4oltB-4q73A:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB305_1
(CHITOSANASE)		 4q73 PROLINE
DEHYDROGENASE
(Bradyrhizobium
diazoefficiens) 		3 / 3 GLY A 832
PRO A 833
GLN A 790
 None
 0.18A 4qwpB-4q73A:
undetectable		 4qwpB-4q73A:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4q73 PROLINE
DEHYDROGENASE
(Bradyrhizobium
diazoefficiens) 		5 / 12 MET A 811
VAL A 812
GLY A 814
ALA A 816
LEU A 819
 None
 1.19A 4rrwB-4q73A:
undetectable		 4rrwB-4q73A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4q73 PROLINE
DEHYDROGENASE
(Bradyrhizobium
diazoefficiens) 		5 / 12 MET A 811
VAL A 812
GLY A 814
ALA A 816
LEU A 819
 None
 1.19A 4rrzB-4q73A:
undetectable		 4rrzB-4q73A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_J_377J401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4q73 PROLINE
DEHYDROGENASE
(Bradyrhizobium
diazoefficiens) 		4 / 6 ASN A 461
TYR A 453
LEU A 454
PHE A 167
 None
 1.26A 4twdI-4q73A:
undetectable
4twdJ-4q73A:
undetectable		 4twdI-4q73A:
14.95
4twdJ-4q73A:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_C_QI9C602_0
(CYTOCHROME P450 2D6)		 4q73 PROLINE
DEHYDROGENASE
(Bradyrhizobium
diazoefficiens) 		5 / 9 LEU A 384
ASP A 323
SER A 319
VAL A 338
PHE A 392
 None
 1.41A 4wnvC-4q73A:
3.6		 4wnvC-4q73A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_2
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		 4q73 PROLINE
DEHYDROGENASE
(Bradyrhizobium
diazoefficiens) 		4 / 6 ILE A 663
PRO A 656
ILE A 741
VAL A 729
 None
 0.95A 4zj8A-4q73A:
3.6		 4zj8A-4q73A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZPH_A_PRLA501_0
(ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
ENDOTHELIAL PAS
DOMAIN-CONTAINING
PROTEIN 1)		 4q73 PROLINE
DEHYDROGENASE
(Bradyrhizobium
diazoefficiens) 		4 / 7 ARG A 284
LEU A 238
SER A 239
GLU A 197
 None
 1.07A 4zphA-4q73A:
undetectable
4zphB-4q73A:
undetectable		 4zphA-4q73A:
17.56
4zphB-4q73A:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_A_SAMA301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 4q73 PROLINE
DEHYDROGENASE
(Bradyrhizobium
diazoefficiens) 		5 / 12 GLY A 913
GLY A 956
THR A 759
ILE A 907
LEU A 959
 None
 0.99A 5bw4A-4q73A:
undetectable		 5bw4A-4q73A:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA303_1
(CHITOSANASE)		 4q73 PROLINE
DEHYDROGENASE
(Bradyrhizobium
diazoefficiens) 		4 / 5 HIS A 871
VAL A 834
GLY A 789
ALA A 788
 None
 0.99A 5hwaA-4q73A:
undetectable		 5hwaA-4q73A:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HYR_B_ESTB601_1
(ESTROGEN RECEPTOR)		 4q73 PROLINE
DEHYDROGENASE
(Bradyrhizobium
diazoefficiens) 		5 / 11 LEU A 328
ALA A 329
LEU A 336
LEU A 309
LEU A 384
 None
 1.15A 5hyrB-4q73A:
undetectable		 5hyrB-4q73A:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_D_ACTD305_0
(CARBONIC ANHYDRASE 4)		 4q73 PROLINE
DEHYDROGENASE
(Bradyrhizobium
diazoefficiens) 		5 / 5 PRO A 485
ALA A 368
ALA A 488
ILE A 489
LEU A  24
 None
SO4  A2004 (-3.3A)
SO4  A2004 ( 4.2A)
None
None
 1.42A 5jncD-4q73A:
undetectable		 5jncD-4q73A:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_B_GCSB405_1
(PREDICTED
ACETYLTRANSFERASE)		 4q73 PROLINE
DEHYDROGENASE
(Bradyrhizobium
diazoefficiens) 		4 / 8 ARG A 356
GLU A 518
PRO A 362
GLY A 360
 GOL  A2007 (-3.7A)
GOL  A2007 ( 3.4A)
None
None
 1.12A 5kgpB-4q73A:
undetectable		 5kgpB-4q73A:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 4q73 PROLINE
DEHYDROGENASE
(Bradyrhizobium
diazoefficiens) 		4 / 8 LEU A 458
LEU A  67
ILE A 922
THR A 139
 None
 1.06A 5ljbA-4q73A:
undetectable		 5ljbA-4q73A:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MQT_C_STIC302_1
(DEOXYCYTIDINE KINASE)		 4q73 PROLINE
DEHYDROGENASE
(Bradyrhizobium
diazoefficiens) 		5 / 12 GLU A 874
VAL A 892
PRO A 773
GLU A 774
ARG A 855
 None
 1.42A 5mqtC-4q73A:
undetectable		 5mqtC-4q73A:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAH_C_RFPC3001_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 4q73 PROLINE
DEHYDROGENASE
(Bradyrhizobium
diazoefficiens) 		5 / 12 LEU A 900
GLN A 801
VAL A 804
SER A 925
ILE A 922
 None
 1.18A 5uahC-4q73A:
1.2		 5uahC-4q73A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 4q73 PROLINE
DEHYDROGENASE
(Bradyrhizobium
diazoefficiens) 		3 / 3 HIS A 166
HIS A 419
ARG A 417
 None
 0.76A 6b58A-4q73A:
3.0		 6b58A-4q73A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
RNA POLYMERASE SIGMA
FACTOR SIGA)		 4q73 PROLINE
DEHYDROGENASE
(Bradyrhizobium
diazoefficiens) 		4 / 4 LEU A 264
ASP A 263
GLN A 260
VAL A 168
 None
 1.37A 6bzoF-4q73A:
3.0		 6bzoF-4q73A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_B_AM2B301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4q73 PROLINE
DEHYDROGENASE
(Bradyrhizobium
diazoefficiens) 		4 / 8 ASP A 230
ARG A 231
HIS A 226
ASP A 272
 None
 1.28A 6mn4B-4q73A:
undetectable		 6mn4B-4q73A:
15.69