SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4q76'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXV_B_PNNB1001_0
(PENICILLIN ACYLASE)		 4q76 CYSTEINE DESULFURASE
2, CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 7 PHE A 105
SER A 239
PHE A  84
ALA A 294
 None
 1.20A 1fxvA-4q76A:
undetectable
1fxvB-4q76A:
undetectable		 1fxvA-4q76A:
19.10
1fxvB-4q76A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4q76 CYSTEINE DESULFURASE
2, CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 4 ALA A 237
VAL A 236
ALA A 109
HIS A 240
 None
None
LLP  A 241 ( 3.9A)
LLP  A 241 ( 3.7A)
 1.26A 1q23F-4q76A:
undetectable		 1q23F-4q76A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 4q76 CYSTEINE DESULFURASE
2, CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 LEU A 366
LEU A  42
ALA A 400
LEU A 327
LEU A 334
 None
 1.24A 1s9pB-4q76A:
undetectable		 1s9pB-4q76A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B60_B_RITB100_2
(GAG-POL POLYPROTEIN)		 4q76 CYSTEINE DESULFURASE
2, CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 11 GLY A 153
ALA A 154
ASP A 129
GLY A 121
PRO A 144
 None
 1.01A 2b60B-4q76A:
undetectable		 2b60B-4q76A:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B7Z_B_MK1B200_1
(HIV-1 PROTEASE)		 4q76 CYSTEINE DESULFURASE
2, CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 GLY A 153
ALA A 154
ASP A 129
GLY A 121
PRO A 144
 None
 0.99A 2b7zA-4q76A:
undetectable		 2b7zA-4q76A:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 4q76 CYSTEINE DESULFURASE
2, CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 11 LEU A 235
LEU A 182
VAL A 212
CYH A 141
ILE A 198
 None
 1.16A 2uxoB-4q76A:
undetectable		 2uxoB-4q76A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 4q76 CYSTEINE DESULFURASE
2, CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 PHE A 356
LEU A 331
VAL A 191
SER A 189
LEU A 392
 None
 1.00A 3dh0A-4q76A:
2.4		 3dh0A-4q76A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_D_TOPD200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4q76 CYSTEINE DESULFURASE
2, CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 9 ALA A 398
LEU A 370
VAL A 358
ILE A 415
LEU A 334
 None
 1.41A 3fl9D-4q76A:
undetectable		 3fl9D-4q76A:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_A_NCAA302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 4q76 CYSTEINE DESULFURASE
2, CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 8 LEU A 161
ALA A 136
SER A 189
SER A 194
 None
 0.89A 3rodA-4q76A:
undetectable		 3rodA-4q76A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROZ_A_NCAA266_0
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 4q76 CYSTEINE DESULFURASE
2, CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 6 LEU A 196
ALA A 184
LEU A 133
THR A 134
 None
 1.06A 3rozA-4q76A:
undetectable		 3rozA-4q76A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB513_1
(HEMOLYTIC LECTIN
CEL-III)		 4q76 CYSTEINE DESULFURASE
2, CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 6 ASN A 190
CYH A 217
ASP A 215
ILE A 113
 LLP  A 241 ( 3.9A)
LLP  A 241 ( 3.2A)
LLP  A 241 ( 2.7A)
None
 1.40A 3w9tB-4q76A:
undetectable		 3w9tB-4q76A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J03_A_FVSA603_1
(BIFUNCTIONAL EPOXIDE
HYDROLASE 2)		 4q76 CYSTEINE DESULFURASE
2, CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 ILE A 378
TYR A 405
PHE A  27
LEU A 308
HIS A 222
 None
 1.31A 4j03A-4q76A:
undetectable		 4j03A-4q76A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_G_TMQG202_1
(DIHYDROFOLATE
REDUCTASE)		 4q76 CYSTEINE DESULFURASE
2, CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 ILE A 201
ALA A 205
LEU A 235
VAL A 236
ILE A 198
 None
 1.10A 4m2xG-4q76A:
undetectable		 4m2xG-4q76A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_B_MXMB807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4q76 CYSTEINE DESULFURASE
2, CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 LEU A 331
ILE A 378
VAL A 376
LEU A  42
LEU A 418
 None
 1.07A 4o1zB-4q76A:
undetectable		 4o1zB-4q76A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_A_ADNA501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 4q76 CYSTEINE DESULFURASE
2, CHLOROPLASTIC
(Arabidopsis
thaliana) 		3 / 3 PRO A 167
LEU A 161
HIS A 389
 None
 0.68A 4pevA-4q76A:
3.8		 4pevA-4q76A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_1
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 4q76 CYSTEINE DESULFURASE
2, CHLOROPLASTIC
(Arabidopsis
thaliana) 		3 / 3 SER A  18
TYR A 319
ASP A 409
 None
 0.83A 4rp8C-4q76A:
0.8		 4rp8C-4q76A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_E_MFXE2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4q76 CYSTEINE DESULFURASE
2, CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 5 SER A  48
ARG A 107
GLY A 249
GLU A 111
 LLP  A 241 ( 3.2A)
None
None
None
 1.08A 5cdqA-4q76A:
undetectable
5cdqB-4q76A:
undetectable
5cdqC-4q76A:
undetectable		 5cdqA-4q76A:
20.52
5cdqB-4q76A:
17.76
5cdqC-4q76A:
20.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		 4q76 CYSTEINE DESULFURASE
2, CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 8 ALA A  46
HIS A 138
ASN A 190
ARG A 379
ARG A 399
 None
LLP  A 241 ( 3.6A)
LLP  A 241 ( 3.9A)
None
None
 0.66A 5db5A-4q76A:
58.3
5db5B-4q76A:
58.7		 5db5A-4q76A:
46.56
5db5B-4q76A:
46.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IM2_A_BEZA401_0
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL)		 4q76 CYSTEINE DESULFURASE
2, CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 HIS A 186
PRO A 167
LEU A 388
LEU A 192
VAL A 191
 None
 1.27A 5im2A-4q76A:
undetectable		 5im2A-4q76A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OS7_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 4q76 CYSTEINE DESULFURASE
2, CHLOROPLASTIC
(Arabidopsis
thaliana) 		3 / 3 HIS A 240
SER A  48
LYS A  50
 LLP  A 241 ( 3.7A)
LLP  A 241 ( 3.2A)
LLP  A 241 ( 4.9A)
 1.08A 5os7A-4q76A:
undetectable		 5os7A-4q76A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OS7_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 4q76 CYSTEINE DESULFURASE
2, CHLOROPLASTIC
(Arabidopsis
thaliana) 		3 / 3 HIS A 240
SER A  48
LYS A 242
 LLP  A 241 ( 3.7A)
LLP  A 241 ( 3.2A)
LLP  A 241 ( 3.5A)
 1.06A 5os7A-4q76A:
undetectable		 5os7A-4q76A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_F_BEZF201_0
(NS3 PROTEASE)		 4q76 CYSTEINE DESULFURASE
2, CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 5 HIS A 383
ALA A 396
SER A 397
TYR A 340
 None
 1.37A 5yodF-4q76A:
undetectable		 5yodF-4q76A:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWV_A_BEZA202_0
(ARA H 8 ALLERGEN)		 4q76 CYSTEINE DESULFURASE
2, CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 4 PHE A 414
ASP A 412
LEU A 331
LYS A 330
 None
 1.46A 6awvA-4q76A:
undetectable		 6awvA-4q76A:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_1
(CYTOCHROME P450 1A1)		 4q76 CYSTEINE DESULFURASE
2, CHLOROPLASTIC
(Arabidopsis
thaliana) 		3 / 3 SER A 397
SER A 355
ALA A 136
 None
 0.64A 6dwnC-4q76A:
0.0		 6dwnC-4q76A:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GMD_B_ACTB402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 4q76 CYSTEINE DESULFURASE
2, CHLOROPLASTIC
(Arabidopsis
thaliana) 		3 / 3 HIS A 240
SER A  48
LYS A  50
 LLP  A 241 ( 3.7A)
LLP  A 241 ( 3.2A)
LLP  A 241 ( 4.9A)
 1.08A 6gmdB-4q76A:
undetectable		 6gmdB-4q76A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GMD_B_ACTB402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 4q76 CYSTEINE DESULFURASE
2, CHLOROPLASTIC
(Arabidopsis
thaliana) 		3 / 3 HIS A 240
SER A  48
LYS A 242
 LLP  A 241 ( 3.7A)
LLP  A 241 ( 3.2A)
LLP  A 241 ( 3.5A)
 1.06A 6gmdB-4q76A:
undetectable		 6gmdB-4q76A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 4q76 CYSTEINE DESULFURASE
2, CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 10 ALA A 184
LEU A 133
ILE A 147
THR A 152
ALA A 154
 None
 1.45A 6h1lA-4q76A:
undetectable		 6h1lA-4q76A:
23.17