SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4q7a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_1
(ADENOSINE DEAMINASE)
4q7a N-ACETYL-ORNITHINE/N
-ACETYL-LYSINE
DEACETYLASE

(Sphaerobacter
thermophilus)
5 / 12 HIS A 329
GLU A 126
HIS A  71
ASP A  95
ASP A 328
None
None
None
None
SO4  A 401 ( 4.6A)
1.27A 1a4lA-4q7aA:
undetectable
1a4lA-4q7aA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_1
(ADENOSINE DEAMINASE)
4q7a N-ACETYL-ORNITHINE/N
-ACETYL-LYSINE
DEACETYLASE

(Sphaerobacter
thermophilus)
5 / 12 HIS A 329
GLU A 126
HIS A  71
ASP A  95
ASP A 328
None
None
None
None
SO4  A 401 ( 4.6A)
1.29A 1a4lB-4q7aA:
undetectable
1a4lB-4q7aA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_1
(ADENOSINE DEAMINASE)
4q7a N-ACETYL-ORNITHINE/N
-ACETYL-LYSINE
DEACETYLASE

(Sphaerobacter
thermophilus)
5 / 12 HIS A 329
GLU A 126
HIS A  71
ASP A  95
ASP A 328
None
None
None
None
SO4  A 401 ( 4.6A)
1.28A 1a4lC-4q7aA:
undetectable
1a4lC-4q7aA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_1
(ADENOSINE DEAMINASE)
4q7a N-ACETYL-ORNITHINE/N
-ACETYL-LYSINE
DEACETYLASE

(Sphaerobacter
thermophilus)
5 / 12 HIS A 329
GLU A 126
HIS A  71
ASP A  95
ASP A 328
None
None
None
None
SO4  A 401 ( 4.6A)
1.30A 1a4lD-4q7aA:
undetectable
1a4lD-4q7aA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_1
(VITAMIN D NUCLEAR
RECEPTOR)
4q7a N-ACETYL-ORNITHINE/N
-ACETYL-LYSINE
DEACETYLASE

(Sphaerobacter
thermophilus)
5 / 12 LEU A 168
LEU A 239
VAL A 166
CYH A 201
VAL A 263
None
1.31A 1db1A-4q7aA:
undetectable
1db1A-4q7aA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ9_A_CAMA503_0
(CYTOCHROME P450-CAM)
4q7a N-ACETYL-ORNITHINE/N
-ACETYL-LYSINE
DEACETYLASE

(Sphaerobacter
thermophilus)
4 / 8 THR A 140
THR A 119
VAL A  56
ASP A  50
GOL  A 402 ( 4.6A)
None
None
GOL  A 402 (-4.3A)
1.10A 1dz9A-4q7aA:
undetectable
1dz9A-4q7aA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O76_B_CAMB1420_0
(CYTOCHROME P450-CAM)
4q7a N-ACETYL-ORNITHINE/N
-ACETYL-LYSINE
DEACETYLASE

(Sphaerobacter
thermophilus)
4 / 8 THR A 140
THR A 119
VAL A  56
ASP A  50
GOL  A 402 ( 4.6A)
None
None
GOL  A 402 (-4.3A)
1.10A 1o76B-4q7aA:
undetectable
1o76B-4q7aA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UYU_A_CAMA1416_0
(CYTOCHROME P450-CAM)
4q7a N-ACETYL-ORNITHINE/N
-ACETYL-LYSINE
DEACETYLASE

(Sphaerobacter
thermophilus)
4 / 8 THR A 140
THR A 119
VAL A  56
ASP A  50
GOL  A 402 ( 4.6A)
None
None
GOL  A 402 (-4.3A)
1.15A 1uyuA-4q7aA:
undetectable
1uyuA-4q7aA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_A_CRNA401_1
(CREATININE
AMIDOHYDROLASE)
4q7a N-ACETYL-ORNITHINE/N
-ACETYL-LYSINE
DEACETYLASE

(Sphaerobacter
thermophilus)
4 / 8 GLU A 151
HIS A  71
ASP A  95
GLU A 127
None
0.81A 1v7zA-4q7aA:
5.5
1v7zA-4q7aA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_B_CRNB3401_1
(CREATININE
AMIDOHYDROLASE)
4q7a N-ACETYL-ORNITHINE/N
-ACETYL-LYSINE
DEACETYLASE

(Sphaerobacter
thermophilus)
4 / 8 GLU A 151
HIS A  71
ASP A  95
GLU A 127
None
0.81A 1v7zB-4q7aA:
4.1
1v7zB-4q7aA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_C_CRNC4401_1
(CREATININE
AMIDOHYDROLASE)
4q7a N-ACETYL-ORNITHINE/N
-ACETYL-LYSINE
DEACETYLASE

(Sphaerobacter
thermophilus)
4 / 8 GLU A 151
HIS A  71
ASP A  95
GLU A 127
None
0.82A 1v7zC-4q7aA:
3.0
1v7zC-4q7aA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_D_CRND5401_1
(CREATININE
AMIDOHYDROLASE)
4q7a N-ACETYL-ORNITHINE/N
-ACETYL-LYSINE
DEACETYLASE

(Sphaerobacter
thermophilus)
4 / 8 GLU A 151
HIS A  71
ASP A  95
GLU A 127
None
0.82A 1v7zD-4q7aA:
5.4
1v7zD-4q7aA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_E_CRNE6401_1
(CREATININE
AMIDOHYDROLASE)
4q7a N-ACETYL-ORNITHINE/N
-ACETYL-LYSINE
DEACETYLASE

(Sphaerobacter
thermophilus)
4 / 8 GLU A 151
HIS A  71
ASP A  95
GLU A 127
None
0.81A 1v7zE-4q7aA:
5.5
1v7zE-4q7aA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_F_CRNF7401_1
(CREATININE
AMIDOHYDROLASE)
4q7a N-ACETYL-ORNITHINE/N
-ACETYL-LYSINE
DEACETYLASE

(Sphaerobacter
thermophilus)
4 / 8 GLU A 151
HIS A  71
ASP A  95
GLU A 127
None
0.82A 1v7zF-4q7aA:
3.7
1v7zF-4q7aA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)
4q7a N-ACETYL-ORNITHINE/N
-ACETYL-LYSINE
DEACETYLASE

(Sphaerobacter
thermophilus)
4 / 5 ASP A 328
GLY A 154
PRO A  99
ALA A  96
SO4  A 401 ( 4.6A)
None
None
None
0.93A 2aohA-4q7aA:
undetectable
2aohA-4q7aA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)
4q7a N-ACETYL-ORNITHINE/N
-ACETYL-LYSINE
DEACETYLASE

(Sphaerobacter
thermophilus)
5 / 12 SER A  24
GLY A  98
ALA A  93
LEU A  88
THR A 344
None
0.96A 2nyuB-4q7aA:
undetectable
2nyuB-4q7aA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGF_A_ADNA501_1
(ADENOSINE DEAMINASE)
4q7a N-ACETYL-ORNITHINE/N
-ACETYL-LYSINE
DEACETYLASE

(Sphaerobacter
thermophilus)
5 / 12 HIS A 329
GLU A 126
HIS A  71
ASP A  95
ASP A 328
None
None
None
None
SO4  A 401 ( 4.6A)
1.26A 2pgfA-4q7aA:
undetectable
2pgfA-4q7aA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_A_CRNA303_1
(CREATININE
AMIDOHYDROLASE)
4q7a N-ACETYL-ORNITHINE/N
-ACETYL-LYSINE
DEACETYLASE

(Sphaerobacter
thermophilus)
4 / 8 GLU A 151
HIS A  71
ASP A  95
GLU A 127
None
0.86A 3a6jA-4q7aA:
3.9
3a6jA-4q7aA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_B_CRNB304_1
(CREATININE
AMIDOHYDROLASE)
4q7a N-ACETYL-ORNITHINE/N
-ACETYL-LYSINE
DEACETYLASE

(Sphaerobacter
thermophilus)
4 / 7 GLU A 151
HIS A  71
ASP A  95
GLU A 127
None
0.86A 3a6jB-4q7aA:
5.3
3a6jB-4q7aA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_C_CRNC305_1
(CREATININE
AMIDOHYDROLASE)
4q7a N-ACETYL-ORNITHINE/N
-ACETYL-LYSINE
DEACETYLASE

(Sphaerobacter
thermophilus)
4 / 8 GLU A 151
HIS A  71
ASP A  95
GLU A 127
None
0.86A 3a6jC-4q7aA:
3.9
3a6jC-4q7aA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_E_CRNE306_1
(CREATININE
AMIDOHYDROLASE)
4q7a N-ACETYL-ORNITHINE/N
-ACETYL-LYSINE
DEACETYLASE

(Sphaerobacter
thermophilus)
4 / 8 GLU A 151
HIS A  71
ASP A  95
GLU A 127
None
0.86A 3a6jE-4q7aA:
3.8
3a6jE-4q7aA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_F_CRNF307_1
(CREATININE
AMIDOHYDROLASE)
4q7a N-ACETYL-ORNITHINE/N
-ACETYL-LYSINE
DEACETYLASE

(Sphaerobacter
thermophilus)
4 / 8 GLU A 151
HIS A  71
ASP A  95
GLU A 127
None
0.86A 3a6jF-4q7aA:
3.7
3a6jF-4q7aA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)
4q7a N-ACETYL-ORNITHINE/N
-ACETYL-LYSINE
DEACETYLASE

(Sphaerobacter
thermophilus)
6 / 12 ALA A 106
GLU A 341
LEU A 337
THR A 102
LEU A  15
ASP A  14
None
1.47A 3gcsA-4q7aA:
undetectable
3gcsA-4q7aA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_A_SAMA770_0
(23S RRNA
METHYLTRANSFERASE)
4q7a N-ACETYL-ORNITHINE/N
-ACETYL-LYSINE
DEACETYLASE

(Sphaerobacter
thermophilus)
5 / 12 LEU A  68
THR A 119
GLY A  70
GLY A 122
ILE A  66
None
1.08A 3nk7A-4q7aA:
undetectable
3nk7A-4q7aA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROZ_A_NCAA266_0
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)
4q7a N-ACETYL-ORNITHINE/N
-ACETYL-LYSINE
DEACETYLASE

(Sphaerobacter
thermophilus)
4 / 6 ASP A 305
LEU A  69
ALA A  96
ASP A  95
None
0.95A 3rozA-4q7aA:
undetectable
3rozA-4q7aA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC610_0
(GBAA_1210 PROTEIN)
4q7a N-ACETYL-ORNITHINE/N
-ACETYL-LYSINE
DEACETYLASE

(Sphaerobacter
thermophilus)
3 / 3 ASN A 223
ALA A 221
ARG A 236
None
0.76A 3tj7C-4q7aA:
undetectable
3tj7D-4q7aA:
undetectable
3tj7C-4q7aA:
18.93
3tj7D-4q7aA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA1_A_08YA600_1
(CYTOCHROME P450 3A4)
4q7a N-ACETYL-ORNITHINE/N
-ACETYL-LYSINE
DEACETYLASE

(Sphaerobacter
thermophilus)
5 / 12 ARG A 240
SER A 246
ALA A 252
THR A 255
ALA A 265
None
1.30A 3ua1A-4q7aA:
undetectable
3ua1A-4q7aA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_C_UEGC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)
4q7a N-ACETYL-ORNITHINE/N
-ACETYL-LYSINE
DEACETYLASE

(Sphaerobacter
thermophilus)
5 / 10 ASP A  50
ALA A  52
GLY A  53
VAL A  56
HIS A 136
GOL  A 402 (-4.3A)
None
None
None
GOL  A 402 (-4.2A)
1.26A 4c5lC-4q7aA:
undetectable
4c5lC-4q7aA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)
4q7a N-ACETYL-ORNITHINE/N
-ACETYL-LYSINE
DEACETYLASE

(Sphaerobacter
thermophilus)
5 / 10 ASP A  50
ALA A  52
GLY A  53
VAL A  56
HIS A 136
GOL  A 402 (-4.3A)
None
None
None
GOL  A 402 (-4.2A)
1.32A 4c5nD-4q7aA:
undetectable
4c5nD-4q7aA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)
4q7a N-ACETYL-ORNITHINE/N
-ACETYL-LYSINE
DEACETYLASE

(Sphaerobacter
thermophilus)
5 / 12 GLU A  29
GLY A 122
ASN A  54
ARG A 132
ILE A  72
None
1.39A 4djfA-4q7aA:
undetectable
4djfA-4q7aA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOR_A_FLPA711_1
(LACTOTRANSFERRIN)
4q7a N-ACETYL-ORNITHINE/N
-ACETYL-LYSINE
DEACETYLASE

(Sphaerobacter
thermophilus)
4 / 7 GLY A 323
VAL A  94
TYR A 320
GLY A 150
None
0.85A 4forA-4q7aA:
undetectable
4forA-4q7aA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVR_A_SALA203_1
(3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE)
4q7a N-ACETYL-ORNITHINE/N
-ACETYL-LYSINE
DEACETYLASE

(Sphaerobacter
thermophilus)
4 / 7 ASP A  95
GLU A 127
HIS A 329
GLU A 126
None
0.97A 4hvrA-4q7aA:
undetectable
4hvrA-4q7aA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PQA_A_X8ZA401_1
(SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE)
4q7a N-ACETYL-ORNITHINE/N
-ACETYL-LYSINE
DEACETYLASE

(Sphaerobacter
thermophilus)
7 / 11 HIS A  71
ASP A  95
GLU A 126
GLU A 127
GLU A 151
GLY A 302
HIS A 329
None
None
None
None
None
SO4  A 401 (-3.2A)
None
0.68A 4pqaA-4q7aA:
34.5
4pqaA-4q7aA:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PUO_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)
4q7a N-ACETYL-ORNITHINE/N
-ACETYL-LYSINE
DEACETYLASE

(Sphaerobacter
thermophilus)
5 / 9 PRO A 217
LEU A 239
VAL A 263
VAL A 253
TRP A 194
None
1.42A 4puoA-4q7aA:
undetectable
4puoA-4q7aA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZP0_A_DXCA500_0
(MULTIDRUG
TRANSPORTER MDFA)
4q7a N-ACETYL-ORNITHINE/N
-ACETYL-LYSINE
DEACETYLASE

(Sphaerobacter
thermophilus)
5 / 10 TYR A  45
LEU A  36
PRO A   7
LEU A  15
GLY A  70
None
1.40A 4zp0A-4q7aA:
undetectable
4zp0A-4q7aA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBM_A_NVPA601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)
4q7a N-ACETYL-ORNITHINE/N
-ACETYL-LYSINE
DEACETYLASE

(Sphaerobacter
thermophilus)
5 / 11 PRO A 217
LEU A 239
VAL A 263
VAL A 253
TRP A 194
None
1.40A 5hbmA-4q7aA:
4.7
5hbmA-4q7aA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)
4q7a N-ACETYL-ORNITHINE/N
-ACETYL-LYSINE
DEACETYLASE

(Sphaerobacter
thermophilus)
5 / 12 GLY A  18
ALA A  55
SER A   4
ILE A   5
MET A  10
None
1.19A 5igvA-4q7aA:
undetectable
5igvA-4q7aA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_0
(ADENOSINE DEAMINASE)
4q7a N-ACETYL-ORNITHINE/N
-ACETYL-LYSINE
DEACETYLASE

(Sphaerobacter
thermophilus)
5 / 12 HIS A 329
GLU A 126
HIS A  71
ASP A  95
ASP A 328
None
None
None
None
SO4  A 401 ( 4.6A)
1.24A 6n91A-4q7aA:
undetectable
6n91A-4q7aA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_0
(ADENOSINE DEAMINASE)
4q7a N-ACETYL-ORNITHINE/N
-ACETYL-LYSINE
DEACETYLASE

(Sphaerobacter
thermophilus)
5 / 12 HIS A 329
GLU A 126
HIS A  71
ASP A  95
ASP A 328
None
None
None
None
SO4  A 401 ( 4.6A)
1.24A 6n91B-4q7aA:
undetectable
6n91B-4q7aA:
14.37