SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4q7e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2501_0
(FERROCHELATASE)		 4q7e RESPONSE REGULATOR
OF A TWO COMPONENT
REGULATORY SYSTEM
(Leptospira
biflexa) 		5 / 12 LEU A 111
PHE A 110
LEU A 107
ILE A 118
VAL A  29
 None
None
SO4  A 203 ( 4.5A)
None
None
 1.36A 1hrkB-4q7eA:
4.4		 1hrkB-4q7eA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN)		 4q7e RESPONSE REGULATOR
OF A TWO COMPONENT
REGULATORY SYSTEM
(Leptospira
biflexa) 		5 / 11 LEU A  14
ILE A   5
LEU A  22
VAL A 117
PHE A 110
 None
 1.24A 1tw4A-4q7eA:
undetectable		 1tw4A-4q7eA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L3G_F_ACTF401_0
(METHYLAMINE
DEHYDROGENASE HEAVY
CHAIN)		 4q7e RESPONSE REGULATOR
OF A TWO COMPONENT
REGULATORY SYSTEM
(Leptospira
biflexa) 		3 / 3 ARG A  91
LEU A  95
GLU A  94
 None
 0.74A 4l3gF-4q7eA:
undetectable		 4l3gF-4q7eA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_A_ACTA1231_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT
PUTATIVE XANTHINE
DEHYDROGENASE YAGT
IRON-SULFUR-BINDING
SUBUNIT)		 4q7e RESPONSE REGULATOR
OF A TWO COMPONENT
REGULATORY SYSTEM
(Leptospira
biflexa) 		3 / 3 ARG A  55
THR A  81
ASP A  53
 None
 0.90A 5g5gA-4q7eA:
undetectable
5g5gB-4q7eA:
undetectable		 5g5gA-4q7eA:
17.99
5g5gB-4q7eA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_2
(ESTROGEN RECEPTOR)		 4q7e RESPONSE REGULATOR
OF A TWO COMPONENT
REGULATORY SYSTEM
(Leptospira
biflexa) 		4 / 6 LEU A  54
LEU A  64
PHE A  79
LEU A  95
 None
 0.99A 5gs4A-4q7eA:
undetectable		 5gs4A-4q7eA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FTP_B_DM2B501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 4q7e RESPONSE REGULATOR
OF A TWO COMPONENT
REGULATORY SYSTEM
(Leptospira
biflexa) 		5 / 9 LEU A 114
PHE A 110
GLU A 109
LEU A 107
VAL A  51
 None
None
None
SO4  A 203 ( 4.5A)
None
 0.96A 6ftpA-4q7eA:
undetectable
6ftpB-4q7eA:
undetectable		 6ftpA-4q7eA:
20.29
6ftpB-4q7eA:
13.95