SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4q7g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD8_0
(GRAMICIDIN A)		 4q7g LEUCOTOXIN LUKDV
(Staphylococcus
aureus) 		3 / 3 VAL A 110
VAL A 192
TRP A 190
 None
 0.93A 1av2C-4q7gA:
undetectable
1av2D-4q7gA:
undetectable		 1av2C-4q7gA:
5.09
1av2D-4q7gA:
5.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		 4q7g LEUCOTOXIN LUKDV
(Staphylococcus
aureus) 		3 / 3 ASP A 180
PHE A 251
VAL A 192
 None
 0.72A 1kijB-4q7gA:
undetectable		 1kijB-4q7gA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA8_0
(GRAMICIDIN D)		 4q7g LEUCOTOXIN LUKDV
(Staphylococcus
aureus) 		3 / 3 VAL A 192
TRP A 190
VAL A 110
 None
 0.88A 2izqA-4q7gA:
undetectable
2izqB-4q7gA:
undetectable		 2izqA-4q7gA:
5.09
2izqB-4q7gA:
5.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_A_ACHA1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4q7g LEUCOTOXIN LUKDV
(Staphylococcus
aureus) 		4 / 7 TYR A 125
SER A 253
GLN A 138
ILE A 148
 None
 1.11A 2xz5A-4q7gA:
undetectable
2xz5B-4q7gA:
2.2		 2xz5A-4q7gA:
18.81
2xz5B-4q7gA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4q7g LEUCOTOXIN LUKDV
(Staphylococcus
aureus) 		4 / 8 TYR A 125
SER A 253
GLN A 138
ILE A 148
 None
 1.15A 2xz5B-4q7gA:
2.2
2xz5E-4q7gA:
2.3		 2xz5B-4q7gA:
18.81
2xz5E-4q7gA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB8_0
(GRAMICIDIN D)		 4q7g LEUCOTOXIN LUKDV
(Staphylococcus
aureus) 		3 / 3 VAL A 110
VAL A 192
TRP A 190
 None
 0.68A 3l8lA-4q7gA:
undetectable
3l8lB-4q7gA:
undetectable		 3l8lA-4q7gA:
5.09
3l8lB-4q7gA:
5.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSH_B_ACTB401_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 4q7g LEUCOTOXIN LUKDV
(Staphylococcus
aureus) 		4 / 5 ARG A 273
LEU A  56
ASN A 296
VAL A 298
 None
 1.31A 5cshB-4q7gA:
undetectable		 5cshB-4q7gA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OS7_B_ACTB401_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 4q7g LEUCOTOXIN LUKDV
(Staphylococcus
aureus) 		4 / 5 ARG A 273
LEU A  56
ASN A 296
VAL A 298
 None
 1.29A 5os7B-4q7gA:
0.8		 5os7B-4q7gA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GMD_A_ACTA401_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 4q7g LEUCOTOXIN LUKDV
(Staphylococcus
aureus) 		4 / 5 ARG A 273
LEU A  56
ASN A 296
VAL A 298
 None
 1.29A 6gmdA-4q7gA:
0.9		 6gmdA-4q7gA:
21.88