SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4q7k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SV5_A_65BA600_0
(REVERSE
TRANSCRIPTASE)		 4q7k ABC TRANSPORTER
(Thermotoga
maritima) 		5 / 10 LEU A 427
LYS A 428
VAL A 463
TYR A 459
LEU A 478
 None
 1.27A 1sv5A-4q7kA:
1.5		 1sv5A-4q7kA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_1
(POL PROTEIN)		 4q7k ABC TRANSPORTER
(Thermotoga
maritima) 		5 / 11 ILE A 523
LEU A 493
ALA A 483
ILE A 448
VAL A 412
 None
 1.13A 2fxdA-4q7kA:
undetectable		 2fxdA-4q7kA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_B_VDYB6178_1
(VITAMIN D
HYDROXYLASE)		 4q7k ABC TRANSPORTER
(Thermotoga
maritima) 		5 / 12 LEU A 540
ILE A 492
THR A 520
VAL A 356
LEU A 382
 None
 1.43A 3a51B-4q7kA:
undetectable		 3a51B-4q7kA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_A_CAMA423_0
(CYTOCHROME P450)		 4q7k ABC TRANSPORTER
(Thermotoga
maritima) 		5 / 10 THR A 521
THR A 530
LEU A 512
LEU A 509
THR A 497
 None
 1.17A 3lxiA-4q7kA:
undetectable		 3lxiA-4q7kA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4q7k ABC TRANSPORTER
(Thermotoga
maritima) 		5 / 12 TYR A 459
ILE A 453
VAL A 440
LEU A 484
VAL A 500
 None
 0.90A 3w68B-4q7kA:
undetectable		 3w68B-4q7kA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_A_CAMA424_0
(CYTOCHROME P450)		 4q7k ABC TRANSPORTER
(Thermotoga
maritima) 		5 / 9 THR A 521
THR A 530
LEU A 512
LEU A 509
THR A 497
 None
 1.16A 4c9kA-4q7kA:
undetectable		 4c9kA-4q7kA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_2
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 4q7k ABC TRANSPORTER
(Thermotoga
maritima) 		3 / 3 LYS A 527
THR A 530
ILE A 508
 None
 0.77A 4e0fB-4q7kA:
undetectable		 4e0fB-4q7kA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8R_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4q7k ABC TRANSPORTER
(Thermotoga
maritima) 		5 / 9 PHE A 470
SER A 471
GLY A 472
LEU A 418
GLY A 467
 None
 1.24A 5l8rA-4q7kA:
undetectable		 5l8rA-4q7kA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA504_1
(CYTOCHROME P450 2C9)		 4q7k ABC TRANSPORTER
(Thermotoga
maritima) 		4 / 8 PHE A 354
PHE A 548
THR A 520
PHE A 522
 None
 1.01A 5x23A-4q7kA:
undetectable		 5x23A-4q7kA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 4q7k ABC TRANSPORTER
(Thermotoga
maritima) 		3 / 3 LYS A 357
PRO A 358
LYS A 517
 None
 0.96A 5y9yA-4q7kA:
undetectable		 5y9yA-4q7kA:
23.17