SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4q80'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA141_0
(LYSOZYME C)		 4q80 SERINE PROTEASE 57
(Homo
sapiens) 		5 / 6 ASP A 222
GLY A 221
THR A 224
PRO A 225
SER A 216
 None
None
None
None
2YS  A 304 (-3.7A)
 1.28A 1n4fA-4q80A:
undetectable		 1n4fA-4q80A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4q80 SERINE PROTEASE 57
(Homo
sapiens) 		5 / 12 ILE A  16
GLY A 197
VAL A 138
SER A  54
HIS A  57
 None
None
None
None
2YS  A 304 (-2.6A)
 1.22A 1nbhA-4q80A:
undetectable		 1nbhA-4q80A:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4q80 SERINE PROTEASE 57
(Homo
sapiens) 		5 / 12 ILE A  16
GLY A 197
VAL A 138
SER A  54
HIS A  57
 None
None
None
None
2YS  A 304 (-2.6A)
 1.23A 1nbhC-4q80A:
undetectable		 1nbhC-4q80A:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4q80 SERINE PROTEASE 57
(Homo
sapiens) 		5 / 12 ILE A  16
GLY A 197
VAL A 138
SER A  54
HIS A  57
 None
None
None
None
2YS  A 304 (-2.6A)
 1.22A 1nbhD-4q80A:
undetectable		 1nbhD-4q80A:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		 4q80 SERINE PROTEASE 57
(Homo
sapiens) 		5 / 12 PHE A  59
GLY A 196
VAL A 231
LEU A 106
LEU A 123
 None
 1.24A 1ya4B-4q80A:
undetectable		 1ya4B-4q80A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OA1_B_ADNB2005_1
(TRYPTOPHAN
HALOGENASE)		 4q80 SERINE PROTEASE 57
(Homo
sapiens) 		4 / 7 GLY A  44
GLY A 197
VAL A  66
LEU A 106
 None
 0.81A 2oa1B-4q80A:
undetectable		 2oa1B-4q80A:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_1_PQN12001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
FUSION PROTEIN OF
PHOTOSYSTEM I
SUBUNIT III AND
SUBUNIT IX)		 4q80 SERINE PROTEASE 57
(Homo
sapiens) 		5 / 11 GLY A 115
ALA A 112
LEU A  68
GLY A  69
ALA A  56
 None
 1.06A 4l6v1-4q80A:
undetectable
4l6v6-4q80A:
undetectable		 4l6v1-4q80A:
16.49
4l6v6-4q80A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 4q80 SERINE PROTEASE 57
(Homo
sapiens) 		3 / 3 SER A  26
ALA A 117
VAL A 118
 None
 0.58A 4o2bA-4q80A:
undetectable		 4o2bA-4q80A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_A_PARA500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 4q80 SERINE PROTEASE 57
(Homo
sapiens) 		5 / 10 SER A 145
PHE A 148
SER A 192
ASP A 226
GLY A 221
 None
None
2YS  A 304 (-4.4A)
None
None
 1.44A 4qb9A-4q80A:
undetectable		 4qb9A-4q80A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDJ_A_SAMA301_0
(MAGNESIUM-PROTOPORPH
YRIN
O-METHYLTRANSFERASE)		 4q80 SERINE PROTEASE 57
(Homo
sapiens) 		5 / 12 VAL A 231
GLY A  44
ILE A 103
LEU A 105
LEU A  46
 None
 0.87A 4qdjA-4q80A:
undetectable		 4qdjA-4q80A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4q80 SERINE PROTEASE 57
(Homo
sapiens) 		3 / 3 SER A  26
ALA A 117
VAL A 118
 None
 0.58A 4x1iA-4q80A:
undetectable		 4x1iA-4q80A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4q80 SERINE PROTEASE 57
(Homo
sapiens) 		3 / 3 SER A  26
ALA A 117
VAL A 118
 None
 0.56A 5eypA-4q80A:
undetectable		 5eypA-4q80A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA816_0
(UNCHARACTERIZED
PROTEIN)		 4q80 SERINE PROTEASE 57
(Homo
sapiens) 		3 / 3 ARG A 244
ARG A 243
ASP A 240
 None
 0.89A 6d8pA-4q80A:
undetectable		 6d8pA-4q80A:
17.04