SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4q82'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GWR_B_ESTB600_1
(OESTROGEN RECEPTOR)		 4q82 PHOSPHOLIPASE/CARBOX
YLESTERASE
(Haliangium
ochraceum) 		5 / 9 LEU A 176
ALA A 202
LEU A 204
HIS A 216
LEU A 220
 None
 1.47A 1gwrB-4q82A:
undetectable		 1gwrB-4q82A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_A_DVAA6_0
(GRAMICIDIN C)		 4q82 PHOSPHOLIPASE/CARBOX
YLESTERASE
(Haliangium
ochraceum) 		3 / 3 ALA A 201
VAL A 203
TRP A 226
 None
 0.88A 1nt6A-4q82A:
undetectable		 1nt6A-4q82A:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_B_DVAB6_0
(GRAMICIDIN C)		 4q82 PHOSPHOLIPASE/CARBOX
YLESTERASE
(Haliangium
ochraceum) 		3 / 3 ALA A 201
VAL A 203
TRP A 226
 None
 0.88A 1nt6B-4q82A:
undetectable		 1nt6B-4q82A:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_A_ACTA1107_0
(C5A PEPTIDASE)		 4q82 PHOSPHOLIPASE/CARBOX
YLESTERASE
(Haliangium
ochraceum) 		4 / 5 LEU A 277
GLY A 280
HIS A 281
ILE A 283
 None
 0.91A 1xf1A-4q82A:
2.3		 1xf1A-4q82A:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q9R_A_BEZA203_0
(PROTEIN OF UNKNOWN
FUNCTION)		 4q82 PHOSPHOLIPASE/CARBOX
YLESTERASE
(Haliangium
ochraceum) 		4 / 5 LEU A 204
GLY A 209
PRO A 244
ILE A 225
 None
 0.80A 2q9rA-4q82A:
undetectable		 2q9rA-4q82A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 4q82 PHOSPHOLIPASE/CARBOX
YLESTERASE
(Haliangium
ochraceum) 		3 / 3 TRP A 286
VAL A 140
ARG A  67
 None
 0.97A 3b0wA-4q82A:
undetectable		 3b0wA-4q82A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_B_V2HB602_0
(CYTOCHROME P450 2R1)		 4q82 PHOSPHOLIPASE/CARBOX
YLESTERASE
(Haliangium
ochraceum) 		5 / 12 THR A 197
ALA A 212
ALA A 153
ILE A 225
THR A 241
 None
 1.29A 3dl9B-4q82A:
undetectable		 3dl9B-4q82A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4q82 PHOSPHOLIPASE/CARBOX
YLESTERASE
(Haliangium
ochraceum) 		5 / 12 ILE A 156
ALA A 153
ALA A 212
LEU A 190
LEU A 204
 None
 1.14A 4lnwA-4q82A:
undetectable		 4lnwA-4q82A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0I_B_ACTB303_0
(SWI5-DEPENDENT HO
EXPRESSION PROTEIN 2)		 4q82 PHOSPHOLIPASE/CARBOX
YLESTERASE
(Haliangium
ochraceum) 		4 / 5 VAL A 223
THR A 197
ASP A 195
LEU A 194
 None
 1.35A 5m0iB-4q82A:
undetectable		 5m0iB-4q82A:
21.55