SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4q85'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_C_ADNC1503_1
(CLASS B ACID
PHOSPHATASE)		 4q85 RIBOSOMAL PROTEIN
S12
METHYLTHIOTRANSFERAS
E ACCESSORY FACTOR
YCAO
(Escherichia
coli) 		4 / 8 ASP A 143
TYR A 573
LEU A  91
GLY A 147
 None
 0.99A 1rmtC-4q85A:
undetectable		 1rmtC-4q85A:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_A_SALA2006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4q85 RIBOSOMAL PROTEIN
S12
METHYLTHIOTRANSFERAS
E ACCESSORY FACTOR
YCAO
(Escherichia
coli) 		4 / 6 ARG A 286
VAL A 194
LEU A 359
ALA A 276
 APC  A 601 ( 3.1A)
None
None
None
 1.07A 2e1qA-4q85A:
undetectable		 2e1qA-4q85A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_A_TPFA2472_1
(CYTOCHROME P450 121)		 4q85 RIBOSOMAL PROTEIN
S12
METHYLTHIOTRANSFERAS
E ACCESSORY FACTOR
YCAO
(Escherichia
coli) 		5 / 11 VAL A 556
ASN A 457
THR A 453
ALA A 565
SER A 568
 None
 1.46A 2ij7A-4q85A:
undetectable		 2ij7A-4q85A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_D_TPFD2473_1
(CYTOCHROME P450 121)		 4q85 RIBOSOMAL PROTEIN
S12
METHYLTHIOTRANSFERAS
E ACCESSORY FACTOR
YCAO
(Escherichia
coli) 		5 / 10 VAL A 556
ASN A 457
THR A 453
ALA A 565
SER A 568
 None
 1.35A 2ij7D-4q85A:
undetectable		 2ij7D-4q85A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_F_TPFF2474_1
(CYTOCHROME P450 121)		 4q85 RIBOSOMAL PROTEIN
S12
METHYLTHIOTRANSFERAS
E ACCESSORY FACTOR
YCAO
(Escherichia
coli) 		5 / 10 VAL A 556
ASN A 457
THR A 453
ALA A 565
SER A 568
 None
 1.35A 2ij7F-4q85A:
undetectable		 2ij7F-4q85A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_A_FUAA2002_1
(SERUM ALBUMIN)		 4q85 RIBOSOMAL PROTEIN
S12
METHYLTHIOTRANSFERAS
E ACCESSORY FACTOR
YCAO
(Escherichia
coli) 		4 / 9 ILE A 385
ARG A 193
PHE A 363
VAL A 370
 None
 0.86A 2vufA-4q85A:
undetectable		 2vufA-4q85A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1160_1
(ALLERGEN ARG R 1)		 4q85 RIBOSOMAL PROTEIN
S12
METHYLTHIOTRANSFERAS
E ACCESSORY FACTOR
YCAO
(Escherichia
coli) 		4 / 6 SER A 162
VAL A 167
TYR A 371
ASP A 163
 None
 1.28A 2x45A-4q85A:
undetectable		 2x45A-4q85A:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZQ9_A_CLSA11_1
(BETA-LACTAMASE
TOHO-1)		 4q85 RIBOSOMAL PROTEIN
S12
METHYLTHIOTRANSFERAS
E ACCESSORY FACTOR
YCAO
(Escherichia
coli) 		4 / 4 GLU A 369
ARG A 160
ASN A 164
ASP A 163
 None
 1.05A 2zq9A-4q85A:
1.9		 2zq9A-4q85A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RFM_A_CFFA330_1
(ADENOSINE RECEPTOR
A2A)		 4q85 RIBOSOMAL PROTEIN
S12
METHYLTHIOTRANSFERAS
E ACCESSORY FACTOR
YCAO
(Escherichia
coli) 		4 / 7 VAL A 117
LEU A 399
ASN A 403
ILE A 173
 None
 1.01A 3rfmA-4q85A:
undetectable		 3rfmA-4q85A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA1_A_08YA600_1
(CYTOCHROME P450 3A4)		 4q85 RIBOSOMAL PROTEIN
S12
METHYLTHIOTRANSFERAS
E ACCESSORY FACTOR
YCAO
(Escherichia
coli) 		5 / 12 PHE A 263
ILE A 214
PHE A 274
THR A 287
ALA A 246
 None
 1.32A 3ua1A-4q85A:
undetectable		 3ua1A-4q85A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_A_P1BA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 4q85 RIBOSOMAL PROTEIN
S12
METHYLTHIOTRANSFERAS
E ACCESSORY FACTOR
YCAO
(Escherichia
coli) 		5 / 12 LEU A 449
LEU A 462
ILE A 464
ILE A 414
TYR A 504
 None
 1.27A 4a79A-4q85A:
undetectable		 4a79A-4q85A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_B_P1BB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 4q85 RIBOSOMAL PROTEIN
S12
METHYLTHIOTRANSFERAS
E ACCESSORY FACTOR
YCAO
(Escherichia
coli) 		5 / 12 LEU A 449
LEU A 462
ILE A 464
ILE A 414
TYR A 504
 None
 1.19A 4a79B-4q85A:
undetectable		 4a79B-4q85A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_A_RGZA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 4q85 RIBOSOMAL PROTEIN
S12
METHYLTHIOTRANSFERAS
E ACCESSORY FACTOR
YCAO
(Escherichia
coli) 		5 / 11 LEU A 449
LEU A 462
ILE A 464
ILE A 414
TYR A 504
 None
 1.29A 4a7aA-4q85A:
undetectable		 4a7aA-4q85A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA506_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4q85 RIBOSOMAL PROTEIN
S12
METHYLTHIOTRANSFERAS
E ACCESSORY FACTOR
YCAO
(Escherichia
coli) 		4 / 4 PRO A 217
LEU A 216
ILE A 214
ARG A 208
 None
 1.10A 4f4dA-4q85A:
undetectable		 4f4dA-4q85A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4q85 RIBOSOMAL PROTEIN
S12
METHYLTHIOTRANSFERAS
E ACCESSORY FACTOR
YCAO
(Escherichia
coli) 		4 / 7 THR A 485
LEU A 428
GLN A 433
LEU A 434
 None
 1.03A 4ib4A-4q85A:
undetectable		 4ib4A-4q85A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G08_A_Z80A1187_1
(FREQUENIN 2)		 4q85 RIBOSOMAL PROTEIN
S12
METHYLTHIOTRANSFERAS
E ACCESSORY FACTOR
YCAO
(Escherichia
coli) 		4 / 6 ILE A 244
PHE A 242
PHE A 335
TRP A 332
 None
 0.73A 5g08A-4q85A:
undetectable		 5g08A-4q85A:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HQA_A_ACRA705_1
(ALPHA-GLUCOSIDASE)		 4q85 RIBOSOMAL PROTEIN
S12
METHYLTHIOTRANSFERAS
E ACCESSORY FACTOR
YCAO
(Escherichia
coli) 		5 / 12 GLU A  78
GLU A 290
LYS A  61
GLU A  75
GLU A 199
 MG  A 603 ( 2.8A)
MG  A 604 ( 2.5A)
APC  A 601 ( 3.3A)
APC  A 601 (-3.2A)
MG  A 603 ( 2.5A)
 1.22A 5hqaA-4q85A:
0.0		 5hqaA-4q85A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 4q85 RIBOSOMAL PROTEIN
S12
METHYLTHIOTRANSFERAS
E ACCESSORY FACTOR
YCAO
(Escherichia
coli) 		5 / 12 ASP A 279
GLY A 281
LEU A 224
ALA A 246
PHE A 343
 None
 1.04A 5kc4E-4q85A:
undetectable		 5kc4E-4q85A:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_A_NCTA402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 4q85 RIBOSOMAL PROTEIN
S12
METHYLTHIOTRANSFERAS
E ACCESSORY FACTOR
YCAO
(Escherichia
coli) 		4 / 8 TYR A 573
THR A  82
TYR A 103
LEU A 378
 None
 1.18A 5kxiA-4q85A:
2.8
5kxiB-4q85A:
2.7		 5kxiA-4q85A:
20.78
5kxiB-4q85A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 4q85 RIBOSOMAL PROTEIN
S12
METHYLTHIOTRANSFERAS
E ACCESSORY FACTOR
YCAO
(Escherichia
coli) 		4 / 8 TYR A 573
THR A  82
TYR A 103
LEU A 378
 None
 1.15A 5kxiD-4q85A:
undetectable
5kxiE-4q85A:
undetectable		 5kxiD-4q85A:
20.78
5kxiE-4q85A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 4q85 RIBOSOMAL PROTEIN
S12
METHYLTHIOTRANSFERAS
E ACCESSORY FACTOR
YCAO
(Escherichia
coli) 		3 / 3 ARG A 127
PHE A 158
LEU A 121
 None
 0.88A 5x1bC-4q85A:
undetectable		 5x1bC-4q85A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNJ_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 4q85 RIBOSOMAL PROTEIN
S12
METHYLTHIOTRANSFERAS
E ACCESSORY FACTOR
YCAO
(Escherichia
coli) 		4 / 8 TYR A 573
THR A  82
TYR A 103
LEU A 378
 None
 1.06A 6cnjD-4q85A:
2.4
6cnjE-4q85A:
2.6		 6cnjD-4q85A:
8.11
6cnjE-4q85A:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4q85 RIBOSOMAL PROTEIN
S12
METHYLTHIOTRANSFERAS
E ACCESSORY FACTOR
YCAO
(Escherichia
coli) 		3 / 3 LEU A 111
ASN A 403
LEU A 136
 None
 0.70A 6exiD-4q85A:
undetectable		 6exiD-4q85A:
8.67