SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4q8g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		 4q8g PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Saccharomyces
cerevisiae) 		4 / 7 THR A 466
ASN A 501
LEU A 828
GLN A 465
 None
 1.10A 1qzrA-4q8gA:
undetectable		 1qzrA-4q8gA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 4q8g PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Saccharomyces
cerevisiae) 		5 / 12 MET A 703
LEU A 735
ILE A 695
SER A 773
PHE A 760
 None
 1.07A 1xlxA-4q8gA:
undetectable		 1xlxA-4q8gA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_A_CIOA603_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4q8g PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Saccharomyces
cerevisiae) 		5 / 12 MET A 703
LEU A 735
ILE A 695
SER A 773
PHE A 760
 None
 1.06A 1xomA-4q8gA:
undetectable		 1xomA-4q8gA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4q8g PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Saccharomyces
cerevisiae) 		5 / 12 MET A 703
LEU A 735
ILE A 695
SER A 773
PHE A 760
 None
 1.08A 1xomB-4q8gA:
undetectable		 1xomB-4q8gA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4q8g PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Saccharomyces
cerevisiae) 		5 / 12 MET A 703
LEU A 735
ILE A 695
SER A 773
PHE A 760
 None
 1.03A 1xoqA-4q8gA:
undetectable		 1xoqA-4q8gA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 4q8g PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Saccharomyces
cerevisiae) 		5 / 12 MET A 703
LEU A 735
ILE A 695
SER A 773
PHE A 760
 None
 0.91A 1xotA-4q8gA:
undetectable		 1xotA-4q8gA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_B_VDNB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 4q8g PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Saccharomyces
cerevisiae) 		5 / 12 MET A 703
LEU A 735
ILE A 695
SER A 773
PHE A 760
 None
 0.99A 1xotB-4q8gA:
undetectable		 1xotB-4q8gA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_2
(MINERALOCORTICOID
RECEPTOR)		 4q8g PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 507
LEU A 805
MET A 823
THR A 485
 None
 1.05A 2oaxD-4q8gA:
undetectable		 2oaxD-4q8gA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_1
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 4q8g PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Saccharomyces
cerevisiae) 		3 / 3 SER A 566
ASP A 826
ASP A 510
 None
 0.71A 2plwA-4q8gA:
undetectable		 2plwA-4q8gA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4q8g PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Saccharomyces
cerevisiae) 		5 / 12 MET A 529
LEU A 550
PHE A 570
LEU A 547
ILE A 519
 None
 1.02A 2pnjB-4q8gA:
undetectable		 2pnjB-4q8gA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_A_J01A500_1
(ORF12)		 4q8g PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Saccharomyces
cerevisiae) 		5 / 10 ILE A 675
LEU A 731
LEU A 673
ALA A 769
LYS A 768
 None
 1.20A 2xf3A-4q8gA:
undetectable		 2xf3A-4q8gA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGP_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 4q8g PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 771
ILE A 695
LEU A 756
ILE A 699
PRO A 732
 None
 1.14A 2ygpA-4q8gA:
undetectable		 2ygpA-4q8gA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_A_URFA400_1
(URIDINE
PHOSPHORYLASE 1)		 4q8g PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Saccharomyces
cerevisiae) 		5 / 9 THR A 757
GLU A 759
LEU A 696
LEU A 771
ILE A 699
 None
 1.44A 3nbqA-4q8gA:
undetectable		 3nbqA-4q8gA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC1_1
(CYTOCHROME P450 2D6)		 4q8g PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 648
GLY A 551
LEU A 553
PHE A 530
PHE A 570
 None
 1.31A 3tbgC-4q8gA:
undetectable		 3tbgC-4q8gA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4q8g PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 741
GLU A 738
VAL A 793
ALA A 794
 None
 1.06A 4nkvC-4q8gA:
undetectable		 4nkvC-4q8gA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NTX_A_AMRA509_1
(ACID-SENSING ION
CHANNEL 1
BASIC PHOSPHOLIPASE
A2 HOMOLOG TX-BETA)		 4q8g PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Saccharomyces
cerevisiae) 		4 / 6 GLU A 745
ASP A 743
GLU A 848
ASN A 617
 None
 1.21A 4ntxA-4q8gA:
undetectable
4ntxC-4q8gA:
undetectable		 4ntxA-4q8gA:
22.13
4ntxC-4q8gA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS6_A_J3ZA302_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14)		 4q8g PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Saccharomyces
cerevisiae) 		4 / 8 GLN A 693
LEU A 739
LEU A 741
THR A 744
 None
 1.14A 5hs6A-4q8gA:
undetectable		 5hs6A-4q8gA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XU8_A_DX4A701_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 2)		 4q8g PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Saccharomyces
cerevisiae) 		5 / 8 GLY A 506
LEU A 507
ASN A 517
GLN A 521
PHE A 824
 None
 0.46A 5xu8A-4q8gA:
23.6		 5xu8A-4q8gA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 4q8g PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 722
THR A 666
VAL A 667
GLU A 653
 None
 1.03A 6fbvC-4q8gA:
undetectable		 6fbvC-4q8gA:
16.09