SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4q8h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		 4q8h PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 522
SER A 758
LEU A 838
GLY A 791
 None
 1.08A 1a4lB-4q8hA:
undetectable		 1a4lB-4q8hA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_CCSA381_0
(ESTROGEN RECEPTOR)		 4q8h PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Saccharomyces
cerevisiae) 		4 / 5 HIS A1015
ALA A 911
SER A1068
HIS A1066
 None
None
MG  A1202 ( 4.8A)
MG  A1202 (-4.0A)
 1.32A 1errA-4q8hA:
undetectable
1errB-4q8hA:
undetectable		 1errA-4q8hA:
16.47
1errB-4q8hA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_2
(ESTROGEN RECEPTOR)		 4q8h PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 741
ASP A 743
MET A 840
LEU A 756
 None
 1.24A 1errB-4q8hA:
undetectable		 1errB-4q8hA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		 4q8h PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Saccharomyces
cerevisiae) 		4 / 7 THR A 466
ASN A 501
LEU A 828
GLN A 465
 None
 1.15A 1qzrA-4q8hA:
undetectable		 1qzrA-4q8hA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_B_ACTB1108_0
(C5A PEPTIDASE)		 4q8h PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Saccharomyces
cerevisiae) 		4 / 6 GLY A 506
ASN A 500
ILE A 564
PHE A 499
 None
 0.89A 1xf1B-4q8hA:
undetectable		 1xf1B-4q8hA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_A_CIOA603_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4q8h PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Saccharomyces
cerevisiae) 		5 / 12 MET A 703
LEU A 735
ILE A 695
SER A 773
PHE A 760
 None
 1.09A 1xomA-4q8hA:
undetectable		 1xomA-4q8hA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4q8h PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Saccharomyces
cerevisiae) 		5 / 12 MET A 703
LEU A 735
ILE A 695
SER A 773
PHE A 760
 None
 1.12A 1xomB-4q8hA:
undetectable		 1xomB-4q8hA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4q8h PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Saccharomyces
cerevisiae) 		5 / 12 MET A 703
LEU A 735
ILE A 695
SER A 773
PHE A 760
 None
 1.04A 1xoqA-4q8hA:
undetectable		 1xoqA-4q8hA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 4q8h PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Saccharomyces
cerevisiae) 		4 / 5 ASP A 959
GLY A 977
ALA A1072
ILE A1069
 None
 0.94A 2aofA-4q8hA:
undetectable		 2aofA-4q8hA:
9.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_2
(ESTROGEN RECEPTOR)		 4q8h PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 741
ASP A 743
MET A 840
LEU A 756
 None
 1.26A 2jfaA-4q8hA:
undetectable		 2jfaA-4q8hA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA507_0
(CHORISMATE SYNTHASE)		 4q8h PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Saccharomyces
cerevisiae) 		3 / 3 LEU A1004
ASN A 871
ARG A1000
 None
 0.85A 2qhfA-4q8hA:
undetectable		 2qhfA-4q8hA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_2
(ESTROGEN RECEPTOR)		 4q8h PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 741
ASP A 743
MET A 840
LEU A 756
 None
 1.25A 2qxsA-4q8hA:
undetectable		 2qxsA-4q8hA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_1
(ESTROGEN RECEPTOR)		 4q8h PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Saccharomyces
cerevisiae) 		6 / 12 THR A 846
ALA A 794
LEU A 805
ILE A 695
LEU A 739
PRO A 619
 None
 1.42A 2qxsB-4q8hA:
undetectable		 2qxsB-4q8hA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_2
(ESTROGEN RECEPTOR)		 4q8h PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 741
ASP A 743
MET A 840
LEU A 756
 None
 1.27A 2qxsB-4q8hA:
undetectable		 2qxsB-4q8hA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 4q8h PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Saccharomyces
cerevisiae) 		3 / 3 TYR A 879
GLU A 540
THR A 548
 None
 0.99A 2y7hB-4q8hA:
undetectable		 2y7hB-4q8hA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 4q8h PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Saccharomyces
cerevisiae) 		3 / 3 LEU A 537
VAL A1002
ARG A1000
 None
 0.78A 3b0wB-4q8hA:
undetectable		 3b0wB-4q8hA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_A_URFA400_1
(URIDINE
PHOSPHORYLASE 1)		 4q8h PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Saccharomyces
cerevisiae) 		5 / 9 THR A 757
GLU A 759
LEU A 696
LEU A 771
ILE A 699
 None
 1.45A 3nbqA-4q8hA:
undetectable		 3nbqA-4q8hA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 4q8h PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Saccharomyces
cerevisiae) 		3 / 3 TYR A 701
LEU A 669
LYS A 668
 None
 0.77A 3sueD-4q8hA:
0.4		 3sueD-4q8hA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 4q8h PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 550
LEU A 547
ILE A 520
ILE A 519
LEU A 574
 None
 1.16A 4j24B-4q8hA:
undetectable		 4j24B-4q8hA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4q8h PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 741
GLU A 738
VAL A 793
ALA A 794
 None
 1.08A 4nkvC-4q8hA:
undetectable		 4nkvC-4q8hA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_E_IPHE101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 4q8h PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Saccharomyces
cerevisiae) 		4 / 7 ILE A1026
HIS A1023
LEU A 939
ALA A 911
 None
 0.86A 5hrqE-4q8hA:
undetectable
5hrqF-4q8hA:
undetectable
5hrqJ-4q8hA:
undetectable		 5hrqE-4q8hA:
3.53
5hrqF-4q8hA:
4.28
5hrqJ-4q8hA:
4.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1103_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 4q8h PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Saccharomyces
cerevisiae) 		4 / 8 THR A 516
GLN A 521
VAL A 533
GLY A 551
 None
 0.84A 5nzyA-4q8hA:
undetectable		 5nzyA-4q8hA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XU8_A_DX4A701_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 2)		 4q8h PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Saccharomyces
cerevisiae) 		5 / 8 GLY A 506
LEU A 507
ASN A 517
GLN A 521
PHE A 824
 None
 0.41A 5xu8A-4q8hA:
21.9		 5xu8A-4q8hA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4q8h PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 650
GLN A 620
LEU A 756
ILE A 699
LEU A 805
 None
 1.18A 5y2tA-4q8hA:
undetectable		 5y2tA-4q8hA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 4q8h PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 722
THR A 666
VAL A 667
GLU A 653
 None
 1.12A 6fbvC-4q8hA:
undetectable		 6fbvC-4q8hA:
21.03