SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4q8k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4q8k ALGINASE
(Pseudoalteromona
s
sp.
SM0524) 		5 / 11 THR A 253
PHE A 316
LEU A 318
VAL A 320
PHE A 348
 None
 1.20A 1q23L-4q8kA:
undetectable		 1q23L-4q8kA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_B_ACTB2002_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 4q8k ALGINASE
(Pseudoalteromona
s
sp.
SM0524) 		4 / 6 ALA A 231
SER A 346
THR A 235
ASN A 322
 None
 1.19A 1yvpB-4q8kA:
undetectable		 1yvpB-4q8kA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAX_A_CSCA1383_1
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 4q8k ALGINASE
(Pseudoalteromona
s
sp.
SM0524) 		5 / 12 LEU A 295
LYS A 349
ARG A 219
GLN A 355
HIS A 258
 None
SO4  A 503 ( 3.9A)
SO4  A 503 (-2.9A)
None
None
 1.43A 2vaxA-4q8kA:
0.0		 2vaxA-4q8kA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAX_J_CSCJ1385_1
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 4q8k ALGINASE
(Pseudoalteromona
s
sp.
SM0524) 		5 / 12 LEU A 295
LYS A 349
ARG A 219
GLN A 355
HIS A 258
 None
SO4  A 503 ( 3.9A)
SO4  A 503 (-2.9A)
None
None
 1.31A 2vaxJ-4q8kA:
undetectable		 2vaxJ-4q8kA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAX_K_CSCK1385_1
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 4q8k ALGINASE
(Pseudoalteromona
s
sp.
SM0524) 		5 / 12 LEU A 295
LYS A 349
ARG A 219
GLN A 355
HIS A 258
 None
SO4  A 503 ( 3.9A)
SO4  A 503 (-2.9A)
None
None
 1.37A 2vaxK-4q8kA:
undetectable		 2vaxK-4q8kA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_B_BEZB261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 4q8k ALGINASE
(Pseudoalteromona
s
sp.
SM0524) 		4 / 8 HIS A 259
ILE A 254
TYR A 353
ARG A 219
 SO4  A 503 (-3.9A)
None
None
SO4  A 503 (-2.9A)
 1.07A 3ccfB-4q8kA:
undetectable		 3ccfB-4q8kA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_2
(DIHYDROFOLATE
REDUCTASE)		 4q8k ALGINASE
(Pseudoalteromona
s
sp.
SM0524) 		3 / 3 ARG A 296
ILE A 254
THR A 274
 None
 0.67A 3ia4D-4q8kA:
undetectable		 3ia4D-4q8kA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4q8k ALGINASE
(Pseudoalteromona
s
sp.
SM0524) 		5 / 12 HIS A 258
LEU A 318
VAL A 327
GLY A 337
SER A 335
 None
 1.00A 3ln1A-4q8kA:
undetectable		 3ln1A-4q8kA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4q8k ALGINASE
(Pseudoalteromona
s
sp.
SM0524) 		5 / 12 HIS A 258
LEU A 318
VAL A 327
GLY A 337
SER A 335
 None
 1.00A 3ln1B-4q8kA:
undetectable		 3ln1B-4q8kA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4q8k ALGINASE
(Pseudoalteromona
s
sp.
SM0524) 		5 / 12 HIS A 258
LEU A 318
VAL A 327
GLY A 337
SER A 335
 None
 1.01A 3ln1C-4q8kA:
undetectable		 3ln1C-4q8kA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4q8k ALGINASE
(Pseudoalteromona
s
sp.
SM0524) 		4 / 7 PHE A 239
TYR A 395
VAL A 393
ILE A 175
 None
 1.03A 4a97E-4q8kA:
undetectable		 4a97E-4q8kA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4q8k ALGINASE
(Pseudoalteromona
s
sp.
SM0524) 		4 / 8 PHE A 239
TYR A 395
VAL A 393
ILE A 175
 None
 1.01A 4a97C-4q8kA:
undetectable		 4a97C-4q8kA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4q8k ALGINASE
(Pseudoalteromona
s
sp.
SM0524) 		4 / 8 PHE A 239
TYR A 395
VAL A 393
ILE A 175
 None
 1.03A 4a97D-4q8kA:
undetectable		 4a97D-4q8kA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4q8k ALGINASE
(Pseudoalteromona
s
sp.
SM0524) 		4 / 8 PHE A 239
TYR A 395
VAL A 393
ILE A 175
 None
 1.03A 4a97G-4q8kA:
undetectable		 4a97G-4q8kA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4q8k ALGINASE
(Pseudoalteromona
s
sp.
SM0524) 		4 / 7 PHE A 239
TYR A 395
VAL A 393
ILE A 175
 None
 1.03A 4a97H-4q8kA:
undetectable		 4a97H-4q8kA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4q8k ALGINASE
(Pseudoalteromona
s
sp.
SM0524) 		4 / 8 PHE A 239
TYR A 395
VAL A 393
ILE A 175
 None
 1.00A 4a97I-4q8kA:
undetectable		 4a97I-4q8kA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_B_QPSB951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 4q8k ALGINASE
(Pseudoalteromona
s
sp.
SM0524) 		4 / 8 GLU A 341
GLU A 302
LYS A 268
ARG A 294
 None
None
SO4  A 502 ( 4.2A)
SO4  A 502 ( 4.4A)
 1.22A 4bqfB-4q8kA:
undetectable		 4bqfB-4q8kA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XZK_A_AG2A700_1
(PUTATIVE
NAD(+)--ARGININE
ADP-RIBOSYLTRANSFERA
SE VIS)		 4q8k ALGINASE
(Pseudoalteromona
s
sp.
SM0524) 		4 / 7 TYR A 270
SER A 272
PHE A 279
GLU A 276
 SO4  A 502 (-4.8A)
None
None
SO4  A 502 ( 4.7A)
 1.39A 4xzkA-4q8kA:
undetectable		 4xzkA-4q8kA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESH_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4q8k ALGINASE
(Pseudoalteromona
s
sp.
SM0524) 		5 / 12 ALA A 208
PHE A 289
GLY A 287
PHE A 378
MET A 247
 None
 1.20A 5eshA-4q8kA:
undetectable		 5eshA-4q8kA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4q8k ALGINASE
(Pseudoalteromona
s
sp.
SM0524) 		5 / 12 HIS A 258
LEU A 318
VAL A 327
GLY A 337
SER A 335
 None
 0.98A 5jw1A-4q8kA:
undetectable		 5jw1A-4q8kA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA810_0
(UNCHARACTERIZED
PROTEIN)		 4q8k ALGINASE
(Pseudoalteromona
s
sp.
SM0524) 		4 / 6 HIS A 259
TYR A 347
GLU A 221
LYS A 349
 SO4  A 503 (-3.9A)
None
None
SO4  A 503 ( 3.9A)
 1.46A 6d8pA-4q8kA:
0.2		 6d8pA-4q8kA:
18.23