SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4q8l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4q8l ALGINASE
(Pseudoalteromona
s
sp.
SM0524) 		5 / 12 TYR A 180
GLY A  97
THR A  98
GLY A  48
TYR A 186
 None
 1.05A 1nbiC-4q8lA:
undetectable		 1nbiC-4q8lA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4q8l ALGINASE
(Pseudoalteromona
s
sp.
SM0524) 		5 / 12 TYR A 180
GLY A  97
THR A  98
GLY A  48
TYR A 186
 None
 1.05A 1nbiD-4q8lA:
undetectable		 1nbiD-4q8lA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4q8l ALGINASE
(Pseudoalteromona
s
sp.
SM0524) 		5 / 11 THR A  86
PHE A 149
LEU A 151
VAL A 153
PHE A 181
 None
 1.22A 1q23L-4q8lA:
undetectable		 1q23L-4q8lA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_B_ACTB2002_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 4q8l ALGINASE
(Pseudoalteromona
s
sp.
SM0524) 		4 / 6 ALA A  64
SER A 179
THR A  68
ASN A 155
 None
 1.13A 1yvpB-4q8lA:
undetectable		 1yvpB-4q8lA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4q8l ALGINASE
(Pseudoalteromona
s
sp.
SM0524) 		5 / 12 HIS A  91
LEU A 151
VAL A 160
GLY A 170
SER A 168
 None
 0.95A 3ln1A-4q8lA:
undetectable		 3ln1A-4q8lA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4q8l ALGINASE
(Pseudoalteromona
s
sp.
SM0524) 		5 / 12 HIS A  91
LEU A 151
VAL A 160
GLY A 170
SER A 168
 None
 0.95A 3ln1B-4q8lA:
undetectable		 3ln1B-4q8lA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4q8l ALGINASE
(Pseudoalteromona
s
sp.
SM0524) 		5 / 12 HIS A  91
LEU A 151
VAL A 160
GLY A 170
SER A 168
 None
 0.96A 3ln1C-4q8lA:
undetectable		 3ln1C-4q8lA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4q8l ALGINASE
(Pseudoalteromona
s
sp.
SM0524) 		4 / 7 TYR A  55
VAL A 221
ILE A  87
ARG A 152
 None
 0.96A 3mssB-4q8lA:
undetectable		 3mssB-4q8lA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4q8l ALGINASE
(Pseudoalteromona
s
sp.
SM0524) 		5 / 12 HIS A  91
LEU A 151
GLY A 170
SER A 168
LEU A 140
 None
 1.12A 3n8xB-4q8lA:
undetectable		 3n8xB-4q8lA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4q8l ALGINASE
(Pseudoalteromona
s
sp.
SM0524) 		4 / 7 PHE A  72
TYR A 228
VAL A 226
ILE A   8
 None
 1.02A 4a97E-4q8lA:
undetectable		 4a97E-4q8lA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4q8l ALGINASE
(Pseudoalteromona
s
sp.
SM0524) 		4 / 8 PHE A  72
TYR A 228
VAL A 226
ILE A   8
 None
 0.99A 4a97C-4q8lA:
undetectable		 4a97C-4q8lA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4q8l ALGINASE
(Pseudoalteromona
s
sp.
SM0524) 		4 / 8 PHE A  72
TYR A 228
VAL A 226
ILE A   8
 None
 1.02A 4a97D-4q8lA:
undetectable		 4a97D-4q8lA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4q8l ALGINASE
(Pseudoalteromona
s
sp.
SM0524) 		4 / 8 PHE A  72
TYR A 228
VAL A 226
ILE A   8
 None
 1.02A 4a97G-4q8lA:
undetectable		 4a97G-4q8lA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4q8l ALGINASE
(Pseudoalteromona
s
sp.
SM0524) 		4 / 7 PHE A  72
TYR A 228
VAL A 226
ILE A   8
 None
 1.01A 4a97H-4q8lA:
undetectable		 4a97H-4q8lA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4q8l ALGINASE
(Pseudoalteromona
s
sp.
SM0524) 		4 / 8 PHE A  72
TYR A 228
VAL A 226
ILE A   8
 None
 0.98A 4a97I-4q8lA:
undetectable		 4a97I-4q8lA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7G_B_ACTB902_0
(3-HYDROXYPROLINE
DEHYDRATSE)		 4q8l ALGINASE
(Pseudoalteromona
s
sp.
SM0524) 		4 / 7 ASP A  95
ASP A 176
SER A 177
SER A  94
 None
 1.09A 4k7gB-4q8lA:
undetectable		 4k7gB-4q8lA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XZK_A_AG2A700_1
(PUTATIVE
NAD(+)--ARGININE
ADP-RIBOSYLTRANSFERA
SE VIS)		 4q8l ALGINASE
(Pseudoalteromona
s
sp.
SM0524) 		4 / 7 TYR A 103
SER A 105
PHE A 112
GLU A 109
 None
 1.40A 4xzkA-4q8lA:
undetectable		 4xzkA-4q8lA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_1
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 4q8l ALGINASE
(Pseudoalteromona
s
sp.
SM0524) 		3 / 3 ARG A  52
LYS A  56
GLU A  21
 None
 0.75A 5d0yA-4q8lA:
undetectable		 5d0yA-4q8lA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESH_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4q8l ALGINASE
(Pseudoalteromona
s
sp.
SM0524) 		5 / 12 ALA A  41
PHE A 122
GLY A 120
PHE A 211
MET A  80
 None
 1.19A 5eshA-4q8lA:
undetectable		 5eshA-4q8lA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4q8l ALGINASE
(Pseudoalteromona
s
sp.
SM0524) 		5 / 12 HIS A  91
LEU A 151
GLY A 170
SER A 168
LEU A 140
 None
 1.06A 5jw1A-4q8lA:
undetectable		 5jw1A-4q8lA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4q8l ALGINASE
(Pseudoalteromona
s
sp.
SM0524) 		5 / 12 HIS A  91
LEU A 151
VAL A 160
GLY A 170
SER A 168
 None
 0.93A 5jw1A-4q8lA:
undetectable		 5jw1A-4q8lA:
17.92