SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4q8r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4q8r PHOSPHATE ABC
TRANSPORTER,
PHOSPHATE-BINDING
PROTEIN
(Clostridium
perfringens) 		5 / 10 THR A 104
PHE A 135
LEU A 113
VAL A  91
ILE A 120
 None
 1.20A 1claA-4q8rA:
undetectable		 1claA-4q8rA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E71_M_ASCM995_0
(MYROSINASE MA1)		 4q8r PHOSPHATE ABC
TRANSPORTER,
PHOSPHATE-BINDING
PROTEIN
(Clostridium
perfringens) 		4 / 7 ILE A 120
TYR A 103
PHE A 141
PHE A 135
 None
 1.13A 1e71M-4q8rA:
undetectable		 1e71M-4q8rA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E72_M_ASCM995_0
(MYROSINASE MA1)		 4q8r PHOSPHATE ABC
TRANSPORTER,
PHOSPHATE-BINDING
PROTEIN
(Clostridium
perfringens) 		4 / 7 ILE A 120
TYR A 103
PHE A 141
PHE A 135
 None
 1.15A 1e72M-4q8rA:
undetectable		 1e72M-4q8rA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PW7_A_RABA645_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4q8r PHOSPHATE ABC
TRANSPORTER,
PHOSPHATE-BINDING
PROTEIN
(Clostridium
perfringens) 		5 / 10 ARG A 125
SER A  13
GLY A  15
GLU A 126
ILE A  36
 PO4  A 301 (-2.9A)
PO4  A 301 (-2.6A)
None
None
None
 1.33A 1pw7A-4q8rA:
undetectable		 1pw7A-4q8rA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PW7_B_RABB646_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4q8r PHOSPHATE ABC
TRANSPORTER,
PHOSPHATE-BINDING
PROTEIN
(Clostridium
perfringens) 		5 / 9 ARG A 125
SER A  13
GLY A  15
GLU A 126
ILE A  36
 PO4  A 301 (-2.9A)
PO4  A 301 (-2.6A)
None
None
None
 1.35A 1pw7B-4q8rA:
undetectable		 1pw7B-4q8rA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_C_SAMC303_0
(HEMK PROTEIN)		 4q8r PHOSPHATE ABC
TRANSPORTER,
PHOSPHATE-BINDING
PROTEIN
(Clostridium
perfringens) 		5 / 12 GLY A  56
ALA A  58
VAL A   6
SER A   7
PHE A  25
 None
 1.16A 1sg9C-4q8rA:
undetectable		 1sg9C-4q8rA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_B_DP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 4q8r PHOSPHATE ABC
TRANSPORTER,
PHOSPHATE-BINDING
PROTEIN
(Clostridium
perfringens) 		5 / 12 VAL A 197
ILE A 243
LEU A 209
GLU A  75
ALA A 134
 None
 1.19A 3apwB-4q8rA:
undetectable		 3apwB-4q8rA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_H_TRUH800_1
(GLUTAMATE RECEPTOR 2)		 4q8r PHOSPHATE ABC
TRANSPORTER,
PHOSPHATE-BINDING
PROTEIN
(Clostridium
perfringens) 		3 / 3 ILE A  45
SER A  11
SER A 129
 None
PO4  A 301 (-2.5A)
PO4  A 301 (-2.6A)
 0.45A 3iltH-4q8rA:
12.1		 3iltH-4q8rA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9W_A_ACTA170_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 4q8r PHOSPHATE ABC
TRANSPORTER,
PHOSPHATE-BINDING
PROTEIN
(Clostridium
perfringens) 		3 / 3 SER A 129
GLY A 130
THR A 131
 PO4  A 301 (-2.6A)
PO4  A 301 (-3.5A)
PO4  A 301 (-3.6A)
 0.07A 3k9wA-4q8rA:
undetectable		 3k9wA-4q8rA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_A_URFA2001_1
(URIDINE
PHOSPHORYLASE)		 4q8r PHOSPHATE ABC
TRANSPORTER,
PHOSPHATE-BINDING
PROTEIN
(Clostridium
perfringens) 		5 / 10 GLY A 140
PHE A 135
GLU A 137
LEU A  96
ILE A  99
 None
 1.26A 3kvrA-4q8rA:
undetectable		 3kvrA-4q8rA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_C_QMRC1214_1
(CAPITELLA TELETA
ACHBP)		 4q8r PHOSPHATE ABC
TRANSPORTER,
PHOSPHATE-BINDING
PROTEIN
(Clostridium
perfringens) 		4 / 8 VAL A 123
TYR A 103
ILE A 159
ILE A 152
 None
 0.96A 4afgD-4q8rA:
undetectable
4afgE-4q8rA:
undetectable		 4afgD-4q8rA:
23.94
4afgE-4q8rA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_0
(WBDD)		 4q8r PHOSPHATE ABC
TRANSPORTER,
PHOSPHATE-BINDING
PROTEIN
(Clostridium
perfringens) 		5 / 12 GLY A 221
ILE A 225
ILE A  55
SER A   5
VAL A   6
 None
 1.00A 4azvA-4q8rA:
undetectable		 4azvA-4q8rA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D9H_A_ADNA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4q8r PHOSPHATE ABC
TRANSPORTER,
PHOSPHATE-BINDING
PROTEIN
(Clostridium
perfringens) 		5 / 11 SER A  53
GLY A  56
VAL A 211
MET A  49
SER A   9
 None
 1.13A 4d9hA-4q8rA:
undetectable		 4d9hA-4q8rA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_A_2FAA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4q8r PHOSPHATE ABC
TRANSPORTER,
PHOSPHATE-BINDING
PROTEIN
(Clostridium
perfringens) 		5 / 11 SER A  53
GLY A  56
VAL A 211
MET A  49
SER A   9
 None
 1.12A 4danA-4q8rA:
undetectable		 4danA-4q8rA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA2)		 4q8r PHOSPHATE ABC
TRANSPORTER,
PHOSPHATE-BINDING
PROTEIN
(Clostridium
perfringens) 		4 / 6 ARG A 132
GLY A 155
ASP A 154
GLY A  40
 None
None
None
PO4  A 301 (-3.6A)
 0.99A 4koeA-4q8rA:
undetectable
4koeB-4q8rA:
undetectable
4koeC-4q8rA:
undetectable		 4koeA-4q8rA:
21.51
4koeB-4q8rA:
21.51
4koeC-4q8rA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_A_STRA601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 4q8r PHOSPHATE ABC
TRANSPORTER,
PHOSPHATE-BINDING
PROTEIN
(Clostridium
perfringens) 		4 / 6 ALA A 134
ILE A 243
GLY A  80
SER A  11
 None
None
None
PO4  A 301 (-2.5A)
 0.77A 4r21A-4q8rA:
undetectable		 4r21A-4q8rA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RFQ_A_SAMA401_1
(HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG)		 4q8r PHOSPHATE ABC
TRANSPORTER,
PHOSPHATE-BINDING
PROTEIN
(Clostridium
perfringens) 		4 / 4 THR A 131
GLY A 155
ASP A 154
SER A  13
 PO4  A 301 (-3.6A)
None
None
PO4  A 301 (-2.6A)
 1.36A 4rfqA-4q8rA:
undetectable		 4rfqA-4q8rA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 4q8r PHOSPHATE ABC
TRANSPORTER,
PHOSPHATE-BINDING
PROTEIN
(Clostridium
perfringens) 		4 / 6 GLY A 155
ASP A 154
GLY A  40
ARG A 132
 None
None
PO4  A 301 (-3.6A)
None
 0.90A 4z53A-4q8rA:
undetectable
4z53B-4q8rA:
undetectable		 4z53A-4q8rA:
17.14
4z53B-4q8rA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_A_SAMA601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 4q8r PHOSPHATE ABC
TRANSPORTER,
PHOSPHATE-BINDING
PROTEIN
(Clostridium
perfringens) 		5 / 12 GLY A 171
ILE A 173
VAL A 163
VAL A 182
VAL A 178
 None
 1.12A 5dpdA-4q8rA:
undetectable		 5dpdA-4q8rA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_B_SAMB601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 4q8r PHOSPHATE ABC
TRANSPORTER,
PHOSPHATE-BINDING
PROTEIN
(Clostridium
perfringens) 		5 / 12 GLY A 171
ILE A 173
VAL A 163
VAL A 182
VAL A 178
 None
 1.14A 5dpdB-4q8rA:
undetectable		 5dpdB-4q8rA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_A_PFLA412_1
(PROTON-GATED ION
CHANNEL)		 4q8r PHOSPHATE ABC
TRANSPORTER,
PHOSPHATE-BINDING
PROTEIN
(Clostridium
perfringens) 		5 / 10 TYR A 103
TYR A 172
ILE A 159
ILE A 173
VAL A 123
 None
 1.40A 5mzrA-4q8rA:
undetectable		 5mzrA-4q8rA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_C_PFLC409_1
(PROTON-GATED ION
CHANNEL)		 4q8r PHOSPHATE ABC
TRANSPORTER,
PHOSPHATE-BINDING
PROTEIN
(Clostridium
perfringens) 		5 / 10 TYR A 103
TYR A 172
ILE A 159
ILE A 173
VAL A 123
 None
 1.41A 5mzrC-4q8rA:
undetectable		 5mzrC-4q8rA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YK2_A_ERYA501_0
(PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER)		 4q8r PHOSPHATE ABC
TRANSPORTER,
PHOSPHATE-BINDING
PROTEIN
(Clostridium
perfringens) 		5 / 11 GLU A  75
GLY A 130
ASP A 133
ALA A  58
ILE A  45
 None
PO4  A 301 (-3.5A)
None
None
None
 1.20A 5yk2A-4q8rA:
undetectable		 5yk2A-4q8rA:
21.62