SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4q98'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RL8_A_RITA9001_1
(PROTEASE RETROPEPSIN)		 4q98 MAJOR FIMBRIAL
SUBUNIT PROTEIN
(Porphyromonas
gingivalis) 		5 / 12 GLY A 261
ALA A 260
GLY A 181
PRO A 198
ALA A 201
 None
 0.76A 1rl8A-4q98A:
undetectable		 1rl8A-4q98A:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_D_T3D602_1
(TRANSTHYRETIN)		 4q98 MAJOR FIMBRIAL
SUBUNIT PROTEIN
(Porphyromonas
gingivalis) 		5 / 12 LEU A  97
LEU A 168
LYS A  73
ALA A  61
VAL A  63
 None
 1.14A 1sn5B-4q98A:
4.7
1sn5D-4q98A:
4.6		 1sn5B-4q98A:
16.03
1sn5D-4q98A:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B7Z_B_MK1B200_2
(HIV-1 PROTEASE)		 4q98 MAJOR FIMBRIAL
SUBUNIT PROTEIN
(Porphyromonas
gingivalis) 		5 / 12 GLY A 261
ALA A 260
GLY A 181
PRO A 198
ALA A 201
 None
 0.80A 2b7zB-4q98A:
undetectable		 2b7zB-4q98A:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA604_0
(GBAA_1210 PROTEIN)		 4q98 MAJOR FIMBRIAL
SUBUNIT PROTEIN
(Porphyromonas
gingivalis) 		4 / 6 GLY A  86
HIS A 149
SER A  36
THR A  34
 None
 0.79A 3tj7A-4q98A:
undetectable
3tj7B-4q98A:
undetectable		 3tj7A-4q98A:
18.50
3tj7B-4q98A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_D_ACTD605_0
(GBAA_1210 PROTEIN)		 4q98 MAJOR FIMBRIAL
SUBUNIT PROTEIN
(Porphyromonas
gingivalis) 		4 / 6 HIS A 149
SER A  36
THR A  34
GLY A  86
 None
 0.79A 3tj7C-4q98A:
undetectable
3tj7D-4q98A:
undetectable		 3tj7C-4q98A:
18.50
3tj7D-4q98A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 4q98 MAJOR FIMBRIAL
SUBUNIT PROTEIN
(Porphyromonas
gingivalis) 		5 / 10 THR A 357
GLY A 235
THR A 238
ILE A 279
VAL A 207
 None
 1.02A 4jx1B-4q98A:
undetectable		 4jx1B-4q98A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 4q98 MAJOR FIMBRIAL
SUBUNIT PROTEIN
(Porphyromonas
gingivalis) 		3 / 3 ASN A 351
PHE A 196
TYR A 256
 None
 0.84A 4u15A-4q98A:
undetectable		 4u15A-4q98A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Y_BEZY801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4q98 MAJOR FIMBRIAL
SUBUNIT PROTEIN
(Porphyromonas
gingivalis) 		4 / 5 ILE A  39
GLY A 136
ILE A  56
LEU A 168
 None
 0.93A 5dzkd-4q98A:
undetectable
5dzkk-4q98A:
undetectable
5dzky-4q98A:
undetectable		 5dzkd-4q98A:
19.35
5dzkk-4q98A:
19.84
5dzky-4q98A:
0.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXF_A_BEZA601_0
(EUGENOL OXIDASE)		 4q98 MAJOR FIMBRIAL
SUBUNIT PROTEIN
(Porphyromonas
gingivalis) 		5 / 9 VAL A 100
TYR A 105
ILE A 133
VAL A 173
LEU A 219
 None
 1.33A 5fxfA-4q98A:
undetectable		 5fxfA-4q98A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXF_B_BEZB601_0
(EUGENOL OXIDASE)		 4q98 MAJOR FIMBRIAL
SUBUNIT PROTEIN
(Porphyromonas
gingivalis) 		5 / 10 VAL A 100
TYR A 105
ILE A 133
VAL A 173
LEU A 219
 None
 1.33A 5fxfB-4q98A:
undetectable		 5fxfB-4q98A:
21.15