SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4q9t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CRB_A_RTLA200_0
(CELLULAR RETINOL
BINDING PROTEIN)		 4q9t NUCLEOPORIN NUP133
(Vanderwaltozyma
polyspora) 		5 / 12 PHE A 350
LEU A 348
ALA A 368
LEU A 367
ILE A 384
 None
 1.12A 1crbA-4q9tA:
3.3		 1crbA-4q9tA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_A_ADNA601_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 4q9t NUCLEOPORIN NUP133
(Vanderwaltozyma
polyspora) 		5 / 12 THR A  79
ASP A 104
LEU A  84
LEU A  81
GLY A 490
 None
 1.20A 1d4fA-4q9tA:
undetectable		 1d4fA-4q9tA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_D_ADND604_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 4q9t NUCLEOPORIN NUP133
(Vanderwaltozyma
polyspora) 		5 / 12 THR A  79
ASP A 104
LEU A  84
LEU A  81
GLY A 490
 None
 1.19A 1d4fD-4q9tA:
undetectable		 1d4fD-4q9tA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4q9t NUCLEOPORIN NUP133
(Vanderwaltozyma
polyspora) 		5 / 12 ILE A 240
LEU A 217
PHE A 193
ILE A 252
ILE A 238
 None
 1.00A 1ra2A-4q9tA:
undetectable		 1ra2A-4q9tA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4q9t NUCLEOPORIN NUP133
(Vanderwaltozyma
polyspora) 		5 / 12 ILE A 240
LEU A 217
PHE A 193
ILE A 252
ILE A 238
 None
 1.02A 1rx2A-4q9tA:
undetectable		 1rx2A-4q9tA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4q9t NUCLEOPORIN NUP133
(Vanderwaltozyma
polyspora) 		4 / 6 ILE A 285
VAL A 433
ILE A 356
ILE A 446
 None
 0.81A 1uwhA-4q9tA:
undetectable		 1uwhA-4q9tA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 4q9t NUCLEOPORIN NUP133
(Vanderwaltozyma
polyspora) 		3 / 3 SER A 146
HIS A 413
ASP A 352
 None
 0.80A 2oxtA-4q9tA:
undetectable		 2oxtA-4q9tA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_1
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 4q9t NUCLEOPORIN NUP133
(Vanderwaltozyma
polyspora) 		3 / 3 SER A 432
ASP A 424
ASP A 480
 None
 0.60A 2plwA-4q9tA:
undetectable		 2plwA-4q9tA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4q9t NUCLEOPORIN NUP133
(Vanderwaltozyma
polyspora) 		5 / 12 ASN A 439
PHE A 437
VAL A 442
LEU A 400
ILE A 463
 None
 1.33A 3elzA-4q9tA:
undetectable		 3elzA-4q9tA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_B_RABB602_1
(ADENOSYLHOMOCYSTEINA
SE)		 4q9t NUCLEOPORIN NUP133
(Vanderwaltozyma
polyspora) 		5 / 12 THR A  79
ASP A 104
LEU A  84
LEU A  81
GLY A 490
 None
 1.19A 3glqB-4q9tA:
undetectable		 3glqB-4q9tA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4q9t NUCLEOPORIN NUP133
(Vanderwaltozyma
polyspora) 		5 / 11 TYR A  72
THR A  69
ALA A 440
ASP A 462
ILE A 463
 None
 1.24A 3id5B-4q9tA:
undetectable		 3id5B-4q9tA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_F_SAMF301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4q9t NUCLEOPORIN NUP133
(Vanderwaltozyma
polyspora) 		5 / 11 TYR A  72
THR A  69
ALA A 440
ASP A 462
ILE A 463
 None
 1.24A 3id5F-4q9tA:
undetectable		 3id5F-4q9tA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRJ_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN
10-MER PEPTIDE)		 4q9t NUCLEOPORIN NUP133
(Vanderwaltozyma
polyspora) 		5 / 12 TYR A 123
VAL A 491
TYR A 483
ILE A 472
ILE A 473
 None
 1.30A 3vrjA-4q9tA:
undetectable
3vrjC-4q9tA:
undetectable		 3vrjA-4q9tA:
20.19
3vrjC-4q9tA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ARC_A_LEUA1001_0
(LEUCINE--TRNA LIGASE)		 4q9t NUCLEOPORIN NUP133
(Vanderwaltozyma
polyspora) 		4 / 7 LEU A 431
TYR A 357
SER A 447
TYR A 398
 None
 1.27A 4arcA-4q9tA:
undetectable		 4arcA-4q9tA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA502_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 4q9t NUCLEOPORIN NUP133
(Vanderwaltozyma
polyspora) 		4 / 8 THR A 444
LEU A 400
VAL A 435
VAL A 433
 None
 0.97A 4em2A-4q9tA:
undetectable		 4em2A-4q9tA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_A_9TPA601_1
(SERUM ALBUMIN)		 4q9t NUCLEOPORIN NUP133
(Vanderwaltozyma
polyspora) 		5 / 12 LEU A 288
ALA A 422
ILE A 286
LEU A 310
GLY A 307
 None
 1.25A 4l9qA-4q9tA:
undetectable		 4l9qA-4q9tA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_2
(ADENOSINE KINASE)		 4q9t NUCLEOPORIN NUP133
(Vanderwaltozyma
polyspora) 		4 / 5 ASN A 204
SER A 136
LEU A 194
ASN A 187
 None
 1.02A 4n09C-4q9tA:
undetectable		 4n09C-4q9tA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4q9t NUCLEOPORIN NUP133
(Vanderwaltozyma
polyspora) 		4 / 5 ILE A 250
LEU A 248
ASP A 218
GLU A 262
 None
 0.89A 4nkxB-4q9tA:
undetectable		 4nkxB-4q9tA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4q9t NUCLEOPORIN NUP133
(Vanderwaltozyma
polyspora) 		5 / 12 THR A  79
ASP A 104
LEU A  84
LEU A  81
GLY A 490
 None
 1.28A 4pfjB-4q9tA:
undetectable		 4pfjB-4q9tA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4q9t NUCLEOPORIN NUP133
(Vanderwaltozyma
polyspora) 		5 / 12 ILE A 240
LEU A 217
PHE A 193
ILE A 252
ILE A 238
 None
 1.12A 5e8qA-4q9tA:
undetectable		 5e8qA-4q9tA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_B_PFLB510_1
(PROTON-GATED ION
CHANNEL)		 4q9t NUCLEOPORIN NUP133
(Vanderwaltozyma
polyspora) 		5 / 6 ILE A 381
ALA A 368
LEU A 379
ILE A 370
TYR A 330
 None
 1.33A 5mvmB-4q9tA:
undetectable
5mvmC-4q9tA:
undetectable		 5mvmB-4q9tA:
11.39
5mvmC-4q9tA:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_A_ECLA1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 4q9t NUCLEOPORIN NUP133
(Vanderwaltozyma
polyspora) 		5 / 7 PHE A  83
LEU A  81
CYH A 486
ILE A 494
ALA A 110
 None
 1.18A 6b5vA-4q9tA:
undetectable
6b5vC-4q9tA:
undetectable		 6b5vA-4q9tA:
8.19
6b5vC-4q9tA:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_C_ECLC1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 4q9t NUCLEOPORIN NUP133
(Vanderwaltozyma
polyspora) 		5 / 7 PHE A  83
LEU A  81
CYH A 486
ILE A 494
ALA A 110
 None
 1.18A 6b5vC-4q9tA:
undetectable
6b5vD-4q9tA:
undetectable		 6b5vC-4q9tA:
8.19
6b5vD-4q9tA:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_D_ECLD1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 4q9t NUCLEOPORIN NUP133
(Vanderwaltozyma
polyspora) 		5 / 7 ALA A 110
PHE A  83
LEU A  81
CYH A 486
ILE A 494
 None
 1.19A 6b5vB-4q9tA:
undetectable
6b5vD-4q9tA:
undetectable		 6b5vB-4q9tA:
8.19
6b5vD-4q9tA:
8.19