SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4qa8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_0
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 4qa8 PUTATIVE LIPOPROTEIN
LPRF
(Mycobacterium
bovis) 		6 / 12 THR A 134
VAL A 141
SER A 142
GLY A 104
THR A 131
ALA A 146
 PJZ  A 301 ( 4.4A)
None
None
None
None
None
 1.38A 1jg4A-4qa8A:
undetectable		 1jg4A-4qa8A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA604_0
(GBAA_1210 PROTEIN)		 4qa8 PUTATIVE LIPOPROTEIN
LPRF
(Mycobacterium
bovis) 		4 / 6 VAL A  78
HIS A  76
SER A 248
THR A 246
 None
 1.14A 3tj7A-4qa8A:
undetectable
3tj7B-4qa8A:
undetectable		 3tj7A-4qa8A:
22.26
3tj7B-4qa8A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC606_0
(GBAA_1210 PROTEIN)		 4qa8 PUTATIVE LIPOPROTEIN
LPRF
(Mycobacterium
bovis) 		4 / 6 VAL A  78
HIS A  76
SER A 248
THR A 246
 None
 1.13A 3tj7C-4qa8A:
undetectable
3tj7D-4qa8A:
1.1		 3tj7C-4qa8A:
22.26
3tj7D-4qa8A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_D_ACTD605_0
(GBAA_1210 PROTEIN)		 4qa8 PUTATIVE LIPOPROTEIN
LPRF
(Mycobacterium
bovis) 		4 / 6 VAL A  78
HIS A  76
SER A 248
THR A 246
 None
 1.14A 3tj7C-4qa8A:
undetectable
3tj7D-4qa8A:
1.1		 3tj7C-4qa8A:
22.26
3tj7D-4qa8A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_A_ADNA353_1
(ADENOSINE KINASE)		 4qa8 PUTATIVE LIPOPROTEIN
LPRF
(Mycobacterium
bovis) 		5 / 12 ILE A 154
ASP A 151
GLY A 153
ASN A  98
GLY A 102
 None
 0.90A 3uboA-4qa8A:
undetectable		 3uboA-4qa8A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 4qa8 PUTATIVE LIPOPROTEIN
LPRF
(Mycobacterium
bovis) 		3 / 3 PRO A 152
VAL A  77
HIS A  76
 PJZ  A 301 (-4.8A)
None
None
 0.77A 4pevC-4qa8A:
undetectable		 4pevC-4qa8A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0P_A_TE4A201_1
(BETA-LACTOGLOBULIN)		 4qa8 PUTATIVE LIPOPROTEIN
LPRF
(Mycobacterium
bovis) 		5 / 12 LEU A  87
ILE A 200
ILE A 197
ILE A 236
VAL A  77
 None
 1.10A 4y0pA-4qa8A:
undetectable		 4y0pA-4qa8A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_B_010B607_0
(HNL ISOENZYME 5)		 4qa8 PUTATIVE LIPOPROTEIN
LPRF
(Mycobacterium
bovis) 		5 / 10 ALA A 106
ALA A  94
VAL A  92
LEU A 156
TYR A 150
 PJZ  A 301 (-3.3A)
PJZ  A 301 ( 4.0A)
None
None
PJZ  A 301 (-3.8A)
 1.27A 5eb5B-4qa8A:
undetectable		 5eb5B-4qa8A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FUK_A_SNPA1236_1
(MROUPO)		 4qa8 PUTATIVE LIPOPROTEIN
LPRF
(Mycobacterium
bovis) 		4 / 7 ILE A 154
ILE A 197
ILE A 245
LEU A 204
 None
None
PJZ  A 301 ( 4.2A)
None
 0.73A 5fukA-4qa8A:
undetectable
5fukB-4qa8A:
undetectable		 5fukA-4qa8A:
24.07
5fukB-4qa8A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_D_ADND502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4qa8 PUTATIVE LIPOPROTEIN
LPRF
(Mycobacterium
bovis) 		3 / 3 THR A 220
THR A  69
LEU A 215
 None
 0.65A 5m66D-4qa8A:
undetectable		 5m66D-4qa8A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MRA_B_DM2B204_1
(SORCIN)		 4qa8 PUTATIVE LIPOPROTEIN
LPRF
(Mycobacterium
bovis) 		4 / 6 THR A 134
ARG A 136
ASP A 139
GLY A 138
 PJZ  A 301 ( 4.4A)
None
None
None
 1.21A 5mraA-4qa8A:
undetectable
5mraB-4qa8A:
undetectable		 5mraA-4qa8A:
20.89
5mraB-4qa8A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUN_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 4qa8 PUTATIVE LIPOPROTEIN
LPRF
(Mycobacterium
bovis) 		5 / 9 VAL A  75
ILE A 245
LEU A 247
ILE A 200
ALA A 106
 None
PJZ  A 301 ( 4.2A)
None
None
PJZ  A 301 (-3.3A)
 1.00A 5nunA-4qa8A:
undetectable		 5nunA-4qa8A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_E_SAME501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4qa8 PUTATIVE LIPOPROTEIN
LPRF
(Mycobacterium
bovis) 		5 / 9 LEU A 156
GLY A 161
SER A  74
VAL A  77
LEU A 247
 None
 1.40A 5o96E-4qa8A:
undetectable
5o96F-4qa8A:
undetectable		 5o96E-4qa8A:
23.88
5o96F-4qa8A:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3A_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 4qa8 PUTATIVE LIPOPROTEIN
LPRF
(Mycobacterium
bovis) 		5 / 12 GLY A 251
ALA A 252
ILE A 155
LEU A 156
PRO A 152
 None
None
PJZ  A 301 (-4.4A)
None
PJZ  A 301 (-4.8A)
 1.13A 6b3aA-4qa8A:
undetectable		 6b3aA-4qa8A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3B_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 4qa8 PUTATIVE LIPOPROTEIN
LPRF
(Mycobacterium
bovis) 		5 / 12 GLY A 251
ALA A 252
ILE A 155
LEU A 156
PRO A 152
 None
None
PJZ  A 301 (-4.4A)
None
PJZ  A 301 (-4.8A)
 1.15A 6b3bA-4qa8A:
undetectable		 6b3bA-4qa8A:
18.44