SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4qa9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_V_TRPV81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
4qa9 EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus)
5 / 10 GLY A 137
SER A 298
GLY A  97
ALA A 302
ILE A 175
None
None
None
EDO  A 414 (-2.7A)
EDO  A 411 (-4.2A)
1.19A 1c9sL-4qa9A:
undetectable
1c9sV-4qa9A:
undetectable
1c9sL-4qa9A:
11.11
1c9sV-4qa9A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRE_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)
4qa9 EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus)
5 / 12 ALA A 329
ASP A 374
LEU A 375
PHE A 378
SER A 180
None
1.06A 1dreA-4qa9A:
undetectable
1dreA-4qa9A:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
4qa9 EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus)
5 / 9 GLY A 137
SER A 298
GLY A  97
ALA A 302
ILE A 175
None
None
None
EDO  A 414 (-2.7A)
EDO  A 411 (-4.2A)
1.17A 1gtfD-4qa9A:
undetectable
1gtfE-4qa9A:
undetectable
1gtfD-4qa9A:
11.11
1gtfE-4qa9A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOM_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)
4qa9 EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus)
5 / 11 ALA A 354
ASP A 374
LEU A 375
PHE A 378
ILE A 194
None
1.13A 1jomA-4qa9A:
undetectable
1jomA-4qa9A:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEI_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)
4qa9 EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus)
4 / 8 ASP A 346
SER A 204
ASN A 202
ILE A 316
EDO  A 405 (-3.2A)
None
EDO  A 405 (-4.7A)
None
0.88A 1meiA-4qa9A:
undetectable
1meiA-4qa9A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_2
(ESTROGEN RECEPTOR
BETA)
4qa9 EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus)
3 / 3 ASP A 187
LEU A 183
HIS A  81
None
0.73A 1qknA-4qa9A:
undetectable
1qknA-4qa9A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)
4qa9 EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus)
5 / 12 ALA A 329
ASP A 374
LEU A 375
PHE A 378
SER A 180
None
0.93A 1rx3A-4qa9A:
undetectable
1rx3A-4qa9A:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_0
(HYPOTHETICAL PROTEIN)
4qa9 EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus)
5 / 12 THR A 293
GLY A 137
GLY A 135
VAL A 103
ILE A 130
None
1.16A 2b25B-4qa9A:
undetectable
2b25B-4qa9A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_N_CHDN1604_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)
4qa9 EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus)
5 / 11 ARG A 151
GLY A 135
GLU A  71
THR A  70
THR A  69
None
1.45A 2eimG-4qa9A:
undetectable
2eimN-4qa9A:
undetectable
2eimO-4qa9A:
undetectable
2eimG-4qa9A:
9.54
2eimN-4qa9A:
21.32
2eimO-4qa9A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)
4qa9 EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus)
4 / 8 LEU A  45
LEU A 284
ASP A  51
ARG A 280
None
0.93A 2j2pA-4qa9A:
undetectable
2j2pB-4qa9A:
undetectable
2j2pA-4qa9A:
21.79
2j2pB-4qa9A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)
4qa9 EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus)
4 / 4 SER A 180
GLY A 176
HIS A 352
ASP A 373
None
1.15A 2oxtC-4qa9A:
undetectable
2oxtC-4qa9A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)
4qa9 EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus)
5 / 12 ILE A 169
ALA A 170
ILE A  94
VAL A 328
GLY A 327
None
0.89A 2qe6A-4qa9A:
undetectable
2qe6A-4qa9A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3V_A_TOPA1169_1
(DIHYDROFOLATE
REDUCTASE)
4qa9 EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus)
5 / 12 ALA A 329
ASP A 374
LEU A 375
PHE A 378
SER A 180
None
0.87A 2w3vA-4qa9A:
undetectable
2w3vA-4qa9A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_B_CHDB1086_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 6A2
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)
4qa9 EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus)
5 / 11 GLU A  71
THR A  70
THR A  69
ARG A 151
GLY A 135
None
1.46A 2zxwA-4qa9A:
undetectable
2zxwB-4qa9A:
undetectable
2zxwT-4qa9A:
undetectable
2zxwA-4qa9A:
21.32
2zxwB-4qa9A:
21.63
2zxwT-4qa9A:
9.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_A_ADNA300_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)
4qa9 EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus)
5 / 12 SER A 180
ALA A 177
GLU A 104
GLY A  97
ASN A 197
None
EDO  A 410 ( 3.6A)
None
None
None
0.97A 3f8wA-4qa9A:
undetectable
3f8wA-4qa9A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_C_ADNC302_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)
4qa9 EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus)
5 / 12 SER A 180
ALA A 177
GLU A 104
GLY A  97
ASN A 197
None
EDO  A 410 ( 3.6A)
None
None
None
0.99A 3f8wC-4qa9A:
2.2
3f8wC-4qa9A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LD6_B_KKKB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
4qa9 EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus)
5 / 12 PHE A 371
PHE A 290
GLY A 296
ALA A 299
ILE A 175
None
None
None
None
EDO  A 411 (-4.2A)
1.40A 3ld6B-4qa9A:
undetectable
3ld6B-4qa9A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_2
(PROTEASE)
4qa9 EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus)
3 / 3 ARG A  60
VAL A 103
THR A 285
None
None
EDO  A 413 ( 3.7A)
0.76A 3ndtA-4qa9A:
undetectable
3ndtA-4qa9A:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA1_1
(CYTOCHROME P450 2D6)
4qa9 EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus)
5 / 12 LEU A 375
PHE A 371
GLY A 193
SER A 180
PHE A 347
None
None
None
None
EDO  A 405 (-2.3A)
1.31A 3tbgA-4qa9A:
undetectable
3tbgA-4qa9A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_G_CHDG103_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)
4qa9 EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus)
5 / 10 ARG A 151
GLY A 135
GLU A  71
THR A  70
THR A  69
None
1.41A 3wg7G-4qa9A:
undetectable
3wg7N-4qa9A:
undetectable
3wg7O-4qa9A:
undetectable
3wg7G-4qa9A:
9.54
3wg7N-4qa9A:
21.32
3wg7O-4qa9A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_B_ASWB1301_1
(DNA TOPOISOMERASE
2-BETA)
4qa9 EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus)
4 / 7 ILE A  77
PRO A 134
GLY A 146
ALA A 155
None
EDO  A 414 (-3.7A)
None
None
0.90A 4g0uB-4qa9A:
1.5
4g0uB-4qa9A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB0_A_ACTA401_0
(UNCHARACTERIZED
PROTEIN)
4qa9 EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus)
5 / 9 GLY A 140
SER A 139
SER A 132
GLY A 137
THR A 295
None
1.42A 4lb0A-4qa9A:
undetectable
4lb0A-4qa9A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)
4qa9 EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus)
3 / 3 ASP A 374
LEU A 375
PHE A 378
None
0.51A 4pthA-4qa9A:
undetectable
4pthA-4qa9A:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)
4qa9 EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus)
5 / 12 ALA A 354
ASP A 374
LEU A 375
PHE A 378
ILE A 194
None
1.12A 4qlgA-4qa9A:
undetectable
4qlgA-4qa9A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJO_D_ERYD1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)
4qa9 EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus)
5 / 11 THR A 293
SER A 298
ALA A  75
THR A 101
GLY A 100
None
1.38A 4zjoD-4qa9A:
undetectable
4zjoD-4qa9A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_O_CHDO302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)
4qa9 EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus)
5 / 10 ARG A 151
GLY A 135
GLU A  71
THR A  70
THR A  69
None
1.38A 5b1aG-4qa9A:
undetectable
5b1aN-4qa9A:
undetectable
5b1aO-4qa9A:
undetectable
5b1aG-4qa9A:
9.54
5b1aN-4qa9A:
21.32
5b1aO-4qa9A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMX_B_RBFB202_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)
4qa9 EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus)
5 / 10 LEU A 260
GLN A 256
GLN A 301
GLY A 135
GLN A 238
None
1.35A 5umxA-4qa9A:
0.0
5umxB-4qa9A:
0.0
5umxA-4qa9A:
14.90
5umxB-4qa9A:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_B_CHDB303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)
4qa9 EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus)
5 / 10 GLU A  71
THR A  70
THR A  69
ARG A 151
GLY A 135
None
1.38A 5wauA-4qa9A:
undetectable
5wauB-4qa9A:
undetectable
5waug-4qa9A:
undetectable
5wauA-4qa9A:
21.32
5wauB-4qa9A:
21.63
5waug-4qa9A:
9.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_B_CHDB304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)
4qa9 EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus)
5 / 11 GLU A  71
THR A  70
THR A  69
ARG A 151
GLY A 135
None
1.37A 5xdqA-4qa9A:
0.0
5xdqB-4qa9A:
undetectable
5xdqT-4qa9A:
undetectable
5xdqA-4qa9A:
21.32
5xdqB-4qa9A:
21.63
5xdqT-4qa9A:
9.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)
4qa9 EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus)
5 / 11 GLU A  71
THR A  70
THR A  69
ARG A 151
GLY A 135
None
1.37A 5xdxA-4qa9A:
0.0
5xdxB-4qa9A:
undetectable
5xdxT-4qa9A:
undetectable
5xdxA-4qa9A:
21.32
5xdxB-4qa9A:
21.63
5xdxT-4qa9A:
9.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_O_CHDO301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)
4qa9 EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus)
5 / 10 ARG A 151
GLY A 135
GLU A  71
THR A  70
THR A  69
None
1.40A 5xdxG-4qa9A:
undetectable
5xdxN-4qa9A:
0.0
5xdxO-4qa9A:
undetectable
5xdxG-4qa9A:
9.54
5xdxN-4qa9A:
21.32
5xdxO-4qa9A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)
4qa9 EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus)
5 / 11 GLU A  71
THR A  70
THR A  69
ARG A 151
GLY A 135
None
1.38A 5zcoA-4qa9A:
0.0
5zcoB-4qa9A:
undetectable
5zcoT-4qa9A:
undetectable
5zcoA-4qa9A:
21.32
5zcoB-4qa9A:
21.63
5zcoT-4qa9A:
9.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_G_CHDG102_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)
4qa9 EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus)
5 / 10 ARG A 151
GLY A 135
GLU A  71
THR A  70
THR A  69
None
1.39A 5zcoG-4qa9A:
undetectable
5zcoN-4qa9A:
0.0
5zcoO-4qa9A:
undetectable
5zcoG-4qa9A:
9.54
5zcoN-4qa9A:
21.32
5zcoO-4qa9A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_B_CHDB301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)
4qa9 EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus)
5 / 11 GLU A  71
THR A  70
THR A  69
ARG A 151
GLY A 135
None
1.38A 5zcpA-4qa9A:
0.0
5zcpB-4qa9A:
undetectable
5zcpT-4qa9A:
undetectable
5zcpA-4qa9A:
21.32
5zcpB-4qa9A:
21.63
5zcpT-4qa9A:
9.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_G_CHDG102_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)
4qa9 EPOXIDE HYDROLASE
(Streptomyces
carzinostaticus)
5 / 10 ARG A 151
GLY A 135
GLU A  71
THR A  70
THR A  69
None
1.38A 5zcpG-4qa9A:
undetectable
5zcpN-4qa9A:
0.0
5zcpO-4qa9A:
undetectable
5zcpG-4qa9A:
9.54
5zcpN-4qa9A:
21.32
5zcpO-4qa9A:
21.63