SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4qae'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JUJ_A_LYAA315_1
(THYMIDYLATE SYNTHASE)		 4qae NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN
(Homo
sapiens) 		5 / 10 ILE A 166
LEU A 137
GLY A  35
PHE A 168
TYR A 138
 None
 1.38A 1jujA-4qaeA:
undetectable		 1jujA-4qaeA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JUJ_A_LYAA315_1
(THYMIDYLATE SYNTHASE)		 4qae NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN
(Homo
sapiens) 		5 / 10 LEU A 137
GLY A  35
PHE A 168
TYR A 138
MET A 120
 None
 1.45A 1jujA-4qaeA:
undetectable		 1jujA-4qaeA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JUJ_B_LYAB315_1
(THYMIDYLATE SYNTHASE)		 4qae NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN
(Homo
sapiens) 		5 / 10 ILE A 166
LEU A 137
GLY A  35
PHE A 168
TYR A 138
 None
 1.38A 1jujB-4qaeA:
undetectable		 1jujB-4qaeA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JUJ_B_LYAB315_1
(THYMIDYLATE SYNTHASE)		 4qae NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN
(Homo
sapiens) 		5 / 10 LEU A 137
GLY A  35
PHE A 168
TYR A 138
MET A 120
 None
 1.46A 1jujB-4qaeA:
undetectable		 1jujB-4qaeA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JUJ_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		 4qae NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN
(Homo
sapiens) 		5 / 10 ILE A 166
LEU A 137
GLY A  35
PHE A 168
TYR A 138
 None
 1.38A 1jujC-4qaeA:
undetectable		 1jujC-4qaeA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JUJ_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		 4qae NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN
(Homo
sapiens) 		5 / 10 LEU A 137
GLY A  35
PHE A 168
TYR A 138
MET A 120
 None
 1.46A 1jujC-4qaeA:
undetectable		 1jujC-4qaeA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JUJ_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		 4qae NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN
(Homo
sapiens) 		5 / 10 ILE A 166
LEU A 137
GLY A  35
PHE A 168
TYR A 138
 None
 1.38A 1jujD-4qaeA:
undetectable		 1jujD-4qaeA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JUJ_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		 4qae NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN
(Homo
sapiens) 		5 / 10 LEU A 137
GLY A  35
PHE A 168
TYR A 138
MET A 120
 None
 1.45A 1jujD-4qaeA:
undetectable		 1jujD-4qaeA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA154_1
(CALMODULIN)		 4qae NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN
(Homo
sapiens) 		4 / 7 LEU A  72
MET A  70
GLU A  77
LEU A  79
 None
 0.98A 1linA-4qaeA:
undetectable		 1linA-4qaeA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_2
(TRANSTHYRETIN)		 4qae NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN
(Homo
sapiens) 		4 / 8 LEU A 144
THR A 136
LEU A 148
VAL A 121
 None
 0.95A 1sn5C-4qaeA:
undetectable		 1sn5C-4qaeA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 4qae NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN
(Homo
sapiens) 		5 / 12 ILE A 153
LEU A 159
LEU A 137
GLY A  35
PHE A 168
 None
 1.11A 1tlsA-4qaeA:
undetectable		 1tlsA-4qaeA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_B_C2FB266_0
(THYMIDYLATE SYNTHASE)		 4qae NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN
(Homo
sapiens) 		5 / 12 ILE A 153
LEU A 159
LEU A 137
GLY A  35
PHE A 168
 None
 1.06A 1tlsB-4qaeA:
undetectable		 1tlsB-4qaeA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TSN_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 4qae NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN
(Homo
sapiens) 		5 / 12 ILE A 153
LEU A 159
LEU A 137
GLY A  35
PHE A 168
 None
 1.10A 1tsnA-4qaeA:
undetectable		 1tsnA-4qaeA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUH_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 4qae NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN
(Homo
sapiens) 		4 / 6 PHE A  83
TYR A  56
THR A  54
VAL A 121
 None
 1.09A 2zuhA-4qaeA:
undetectable		 2zuhA-4qaeA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWT_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 4qae NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN
(Homo
sapiens) 		4 / 7 PHE A  83
TYR A  56
THR A  54
VAL A 121
 None
 1.04A 2zwtA-4qaeA:
undetectable		 2zwtA-4qaeA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 4qae NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN
(Homo
sapiens) 		5 / 12 MET A  49
ILE A  68
MET A  70
VAL A  66
TYR A  56
 None
 1.27A 3g8iA-4qaeA:
undetectable		 3g8iA-4qaeA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 4qae NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN
(Homo
sapiens) 		5 / 12 TYR A 138
ILE A  68
MET A  70
VAL A  66
TYR A  56
 None
 1.25A 3g8iA-4qaeA:
undetectable		 3g8iA-4qaeA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRH_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 4qae NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN
(Homo
sapiens) 		4 / 7 PHE A  83
TYR A  56
THR A  54
VAL A 121
 None
 1.03A 3wrhA-4qaeA:
undetectable		 3wrhA-4qaeA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_D_C2FD302_0
(THYMIDYLATE SYNTHASE)		 4qae NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN
(Homo
sapiens) 		5 / 11 ILE A 153
LEU A 159
LEU A 137
GLY A  35
PHE A 168
 None
 1.16A 4fogD-4qaeA:
undetectable		 4fogD-4qaeA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_E_D16E301_1
(THYMIDYLATE SYNTHASE)		 4qae NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN
(Homo
sapiens) 		5 / 12 ILE A 166
LEU A 137
GLY A  35
PHE A 168
TYR A 138
 None
 1.33A 4foxE-4qaeA:
undetectable		 4foxE-4qaeA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK6_B_LURB201_1
(TRANSTHYRETIN)		 4qae NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN
(Homo
sapiens) 		4 / 8 LEU A 144
THR A 136
LEU A 148
VAL A 121
 None
 0.94A 4ik6B-4qaeA:
undetectable		 4ik6B-4qaeA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4G_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 4qae NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN
(Homo
sapiens) 		4 / 7 PHE A  83
TYR A  56
THR A  54
VAL A 121
 None
 1.07A 4l4gA-4qaeA:
undetectable		 4l4gA-4qaeA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_B_FOZB401_0
(THYMIDYLATE SYNTHASE)		 4qae NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN
(Homo
sapiens) 		5 / 12 ILE A 166
LEU A 137
GLY A  35
PHE A 168
TYR A 138
 None
 1.33A 6qyaB-4qaeA:
undetectable		 6qyaB-4qaeA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_D_FOZD401_0
(THYMIDYLATE SYNTHASE)		 4qae NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN
(Homo
sapiens) 		5 / 12 ILE A 166
LEU A 137
GLY A  35
PHE A 168
TYR A 138
 None
 1.35A 6qyaD-4qaeA:
undetectable		 6qyaD-4qaeA:
20.25