SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4qam'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 4qam X-LINKED RETINITIS
PIGMENTOSA GTPASE
REGULATOR-INTERACTIN
G PROTEIN 1
(Homo
sapiens) 		5 / 10 VAL B1265
VAL B1133
VAL B1142
VAL B1144
LEU B1263
 None
 1.27A 1fe2A-4qamB:
undetectable		 1fe2A-4qamB:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1162_1
(ALLERGEN ARG R 1)		 4qam X-LINKED RETINITIS
PIGMENTOSA GTPASE
REGULATOR-INTERACTIN
G PROTEIN 1
(Homo
sapiens) 		3 / 3 GLU B1245
HIS B1174
GLU B1121
 None
 0.83A 2x45B-4qamB:
undetectable		 2x45B-4qamB:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		 4qam X-LINKED RETINITIS
PIGMENTOSA GTPASE
REGULATOR-INTERACTIN
G PROTEIN 1
(Homo
sapiens) 		3 / 3 GLU B1245
HIS B1174
GLU B1121
 None
 0.85A 2x45C-4qamB:
undetectable		 2x45C-4qamB:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4qam X-LINKED RETINITIS
PIGMENTOSA GTPASE
REGULATOR-INTERACTIN
G PROTEIN 1
(Homo
sapiens) 		5 / 12 ALA B1269
SER B1239
LEU B1273
ALA B1270
LEU B1248
 None
 1.13A 3dzyA-4qamB:
undetectable		 3dzyA-4qamB:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		 4qam X-LINKED RETINITIS
PIGMENTOSA GTPASE
REGULATOR-INTERACTIN
G PROTEIN 1
(Homo
sapiens) 		4 / 6 ASP B1242
GLN B1246
LEU B1248
PHE B1209
 None
 1.06A 6ekuA-4qamB:
undetectable		 6ekuA-4qamB:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNA_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 4qam X-LINKED RETINITIS
PIGMENTOSA GTPASE
REGULATOR-INTERACTIN
G PROTEIN 1
(Homo
sapiens) 		3 / 3 ARG B1189
LYS B1177
TYR B1146
 None
 1.21A 6gnaA-4qamB:
undetectable		 6gnaA-4qamB:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNB_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 4qam X-LINKED RETINITIS
PIGMENTOSA GTPASE
REGULATOR-INTERACTIN
G PROTEIN 1
(Homo
sapiens) 		3 / 3 ARG B1189
LYS B1177
TYR B1146
 None
 1.21A 6gnbA-4qamB:
undetectable		 6gnbA-4qamB:
22.03