SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4qan'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AKD_A_CAMA420_0
(CYTOCHROME P450CAM)		 4qan HYPOTHETICAL PROTEIN
([Ruminococcus]
gnavus) 		5 / 11 THR A  94
GLY A 206
THR A 190
VAL A 192
VAL A 171
 None
 1.29A 1akdA-4qanA:
undetectable		 1akdA-4qanA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPK_A_ACAA80_1
(PLASMINOGEN)		 4qan HYPOTHETICAL PROTEIN
([Ruminococcus]
gnavus) 		4 / 6 PRO A 232
ASP A  72
ASP A  74
TYR A  63
 None
 1.43A 1hpkA-4qanA:
undetectable		 1hpkA-4qanA:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_A_T44A128_1
(TRANSTHYRETIN)		 4qan HYPOTHETICAL PROTEIN
([Ruminococcus]
gnavus) 		5 / 10 LEU A 271
GLU A  35
ALA A 243
ALA A 122
LEU A 287
 None
 1.36A 1ie4A-4qanA:
undetectable
1ie4C-4qanA:
undetectable		 1ie4A-4qanA:
15.46
1ie4C-4qanA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWE_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 4qan HYPOTHETICAL PROTEIN
([Ruminococcus]
gnavus) 		4 / 7 VAL A 340
TYR A 355
GLY A 357
TRP A 379
 None
 1.01A 1lweA-4qanA:
undetectable		 1lweA-4qanA:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QLT_A_ACTA601_0
(VANILLYL-ALCOHOL
OXIDASE)		 4qan HYPOTHETICAL PROTEIN
([Ruminococcus]
gnavus) 		4 / 5 TYR A 370
PHE A 258
ILE A 259
TYR A 359
 None
 1.30A 1qltA-4qanA:
undetectable		 1qltA-4qanA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QLT_B_ACTB601_0
(VANILLYL-ALCOHOL
OXIDASE)		 4qan HYPOTHETICAL PROTEIN
([Ruminococcus]
gnavus) 		4 / 5 TYR A 370
PHE A 258
ILE A 259
TYR A 359
 None
 1.32A 1qltB-4qanA:
undetectable		 1qltB-4qanA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SV5_A_65BA600_0
(REVERSE
TRANSCRIPTASE)		 4qan HYPOTHETICAL PROTEIN
([Ruminococcus]
gnavus) 		5 / 10 LEU A  68
LYS A  69
VAL A  61
VAL A 147
LEU A 203
 None
 1.48A 1sv5A-4qanA:
undetectable		 1sv5A-4qanA:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VAO_A_ACTA601_0
(VANILLYL-ALCOHOL
OXIDASE)		 4qan HYPOTHETICAL PROTEIN
([Ruminococcus]
gnavus) 		4 / 5 TYR A 370
PHE A 258
ILE A 259
TYR A 359
 None
 1.29A 1vaoA-4qanA:
undetectable		 1vaoA-4qanA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VAO_B_ACTB601_0
(VANILLYL-ALCOHOL
OXIDASE)		 4qan HYPOTHETICAL PROTEIN
([Ruminococcus]
gnavus) 		4 / 5 TYR A 370
PHE A 258
ILE A 259
TYR A 359
 None
 1.29A 1vaoB-4qanA:
undetectable		 1vaoB-4qanA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		 4qan HYPOTHETICAL PROTEIN
([Ruminococcus]
gnavus) 		5 / 12 GLY A 188
VAL A 178
LEU A 135
SER A 136
LEU A 145
 None
 1.25A 1ya4B-4qanA:
undetectable		 1ya4B-4qanA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1N_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 4qan HYPOTHETICAL PROTEIN
([Ruminococcus]
gnavus) 		5 / 11 THR A  94
GLY A 206
THR A 190
VAL A 192
VAL A 171
 None
 1.24A 2a1nA-4qanA:
undetectable		 2a1nA-4qanA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO5_A_CHDA131_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 4qan HYPOTHETICAL PROTEIN
([Ruminococcus]
gnavus) 		5 / 12 ILE A 381
ILE A 259
LEU A 335
THR A 368
PHE A 304
 None
 1.07A 2qo5A-4qanA:
undetectable		 2qo5A-4qanA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_B_PZIB802_0
(GLUTAMATE RECEPTOR 2)		 4qan HYPOTHETICAL PROTEIN
([Ruminococcus]
gnavus) 		3 / 3 SER A  44
ASP A  72
ASN A  71
 None
 0.99A 3lsfB-4qanA:
undetectable
3lsfE-4qanA:
undetectable		 3lsfB-4qanA:
22.38
3lsfE-4qanA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_E_PZIE802_0
(GLUTAMATE RECEPTOR 2)		 4qan HYPOTHETICAL PROTEIN
([Ruminococcus]
gnavus) 		3 / 3 ASP A  72
ASN A  71
SER A  44
 None
 1.02A 3lsfB-4qanA:
undetectable
3lsfE-4qanA:
undetectable		 3lsfB-4qanA:
22.38
3lsfE-4qanA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_A_CAMA423_0
(CYTOCHROME P450)		 4qan HYPOTHETICAL PROTEIN
([Ruminococcus]
gnavus) 		5 / 10 THR A  94
GLY A 206
THR A 190
VAL A 192
VAL A 171
 None
 1.32A 3lxiA-4qanA:
undetectable		 3lxiA-4qanA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_0
(2'-O-METHYL
TRANSFERASE)		 4qan HYPOTHETICAL PROTEIN
([Ruminococcus]
gnavus) 		5 / 12 GLY A 394
SER A 383
PRO A 387
LEU A 297
PHE A 304
 None
 1.41A 3r24A-4qanA:
undetectable		 3r24A-4qanA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4qan HYPOTHETICAL PROTEIN
([Ruminococcus]
gnavus) 		5 / 11 ILE A 341
GLY A 369
ALA A 386
THR A 371
VAL A 352
 None
 1.17A 3rukD-4qanA:
undetectable		 3rukD-4qanA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA505_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4qan HYPOTHETICAL PROTEIN
([Ruminococcus]
gnavus) 		3 / 3 THR A 345
ASN A 348
GLU A 347
 None
 0.81A 3v4tA-4qanA:
undetectable
3v4tC-4qanA:
undetectable		 3v4tA-4qanA:
22.99
3v4tC-4qanA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4qan HYPOTHETICAL PROTEIN
([Ruminococcus]
gnavus) 		4 / 7 GLU A 175
GLU A 152
GLU A 173
GLU A 159
 None
 1.19A 4mj8C-4qanA:
undetectable		 4mj8C-4qanA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCU_A_SAMA603_0
(CYSTATHIONINE
BETA-SYNTHASE)		 4qan HYPOTHETICAL PROTEIN
([Ruminococcus]
gnavus) 		4 / 7 ASP A 105
PRO A  99
THR A 211
ASP A 212
 None
 0.86A 4pcuA-4qanA:
undetectable		 4pcuA-4qanA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H4D_A_BBIA403_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 4qan HYPOTHETICAL PROTEIN
([Ruminococcus]
gnavus) 		4 / 6 GLU A 248
PHE A 273
GLU A  37
VAL A  38
 None
 1.02A 5h4dA-4qanA:
undetectable		 5h4dA-4qanA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_B_SAMB301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4qan HYPOTHETICAL PROTEIN
([Ruminococcus]
gnavus) 		5 / 12 ALA A 261
GLN A 382
PHE A 273
SER A 383
THR A 371
 None
 1.17A 5hfjB-4qanA:
undetectable		 5hfjB-4qanA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_1
(CDL2.2)		 4qan HYPOTHETICAL PROTEIN
([Ruminococcus]
gnavus) 		5 / 12 LEU A  39
PHE A 241
LEU A 119
ILE A 262
THR A 275
 None
 1.32A 5ienA-4qanA:
4.5		 5ienA-4qanA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LRB_A_ACRA1003_1
(ALPHA-1,4 GLUCAN
PHOSPHORYLASE)		 4qan HYPOTHETICAL PROTEIN
([Ruminococcus]
gnavus) 		4 / 6 GLU A 123
PHE A 117
THR A 110
TYR A 209
 None
 1.44A 5lrbA-4qanA:
undetectable		 5lrbA-4qanA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_D_ACTD404_0
(L-LYSINE
3-HYDROXYLASE)		 4qan HYPOTHETICAL PROTEIN
([Ruminococcus]
gnavus) 		4 / 6 GLN A 193
GLU A  84
ALA A 168
GLN A 169
 None
 1.29A 6f6jC-4qanA:
undetectable
6f6jD-4qanA:
undetectable		 6f6jC-4qanA:
23.20
6f6jD-4qanA:
23.20