SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4qax'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_A_PPFA410_1
(PHOSPHONOACETATE
HYDROLASE)
4qax 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Staphylococcus
aureus)
4 / 5 ASP A 397
HIS A 401
HIS A 439
HIS A 456
MN  A 601 (-2.4A)
MN  A 601 (-3.4A)
MN  A 602 (-3.2A)
MN  A 601 (-3.6A)
0.54A 1ei6A-4qaxA:
18.4
1ei6A-4qaxA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_C_PPFC413_1
(PHOSPHONOACETATE
HYDROLASE)
4qax 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Staphylococcus
aureus)
5 / 8 ASP A  12
ASP A 397
HIS A 401
HIS A 439
HIS A 456
MN  A 602 (-2.1A)
MN  A 601 (-2.4A)
MN  A 601 (-3.4A)
MN  A 602 (-3.2A)
MN  A 601 (-3.6A)
0.57A 1ei6C-4qaxA:
18.3
1ei6C-4qaxA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG3_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)
4qax 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Staphylococcus
aureus)
5 / 11 GLN A 493
GLY A 479
GLY A  72
GLY A 476
LEU A 502
None
1.13A 1jg3A-4qaxA:
4.3
1jg3A-4qaxA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KB9_A_PCFA514_0
(CYTOCHROME B
CYTOCHROME C1, HEME
PROTEIN
UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)
4qax 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Staphylococcus
aureus)
4 / 8 SER A 265
ILE A 252
VAL A 245
SER A 109
None
1.17A 1kb9A-4qaxA:
undetectable
1kb9C-4qaxA:
undetectable
1kb9D-4qaxA:
undetectable
1kb9E-4qaxA:
undetectable
1kb9A-4qaxA:
22.59
1kb9C-4qaxA:
21.48
1kb9D-4qaxA:
19.61
1kb9E-4qaxA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_1
(ALPHA-AMYLASE)
4qax 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Staphylococcus
aureus)
5 / 12 VAL A 422
GLY A 420
ASN A 395
ALA A 370
ILE A 354
None
1.20A 1kxhA-4qaxA:
undetectable
1kxhA-4qaxA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ND4_A_KANA1300_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E)
4qax 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Staphylococcus
aureus)
5 / 10 ASP A 192
ARG A 194
ARG A 260
ASP A 259
GLU A 231
None
None
2PG  A 603 (-3.1A)
2PG  A 603 (-3.4A)
None
1.23A 1nd4A-4qaxA:
0.0
1nd4A-4qaxA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ND4_B_KANB2300_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E)
4qax 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Staphylococcus
aureus)
5 / 9 ASP A 192
ARG A 194
ARG A 260
ASP A 259
GLU A 231
None
None
2PG  A 603 (-3.1A)
2PG  A 603 (-3.4A)
None
1.19A 1nd4B-4qaxA:
0.0
1nd4B-4qaxA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA888_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)
4qax 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Staphylococcus
aureus)
4 / 6 MET A 398
ALA A 394
GLU A 327
GLU A 329
MN  A 601 ( 4.9A)
None
None
None
1.47A 1qhyA-4qaxA:
2.7
1qhyA-4qaxA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOF_A_PNNA1312_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)
4qax 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Staphylococcus
aureus)
5 / 11 ARG A 153
HIS A 401
ASP A 397
HIS A 456
ARG A 257
2PG  A 603 (-3.8A)
MN  A 601 (-3.4A)
MN  A 601 (-2.4A)
MN  A 601 (-3.6A)
2PG  A 603 (-2.6A)
1.44A 1uofA-4qaxA:
undetectable
1uofA-4qaxA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)
4qax 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Staphylococcus
aureus)
4 / 6 ARG A 324
ILE A  69
ALA A 482
ALA A 315
None
0.96A 1w0gA-4qaxA:
undetectable
1w0gA-4qaxA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)
4qax 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Staphylococcus
aureus)
3 / 3 LYS A 425
ASP A 385
ASN A 382
None
0.84A 2bm9A-4qaxA:
6.1
2bm9A-4qaxA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)
4qax 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Staphylococcus
aureus)
5 / 12 LEU A 485
LEU A 488
ILE A  69
VAL A 470
VAL A 463
None
1.27A 2pnjB-4qaxA:
3.6
2pnjB-4qaxA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)
4qax 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Staphylococcus
aureus)
4 / 6 PRO A 494
ILE A 311
ASN A 318
LEU A 320
None
1.20A 2wekB-4qaxA:
3.7
2wekB-4qaxA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGP_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)
4qax 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Staphylococcus
aureus)
5 / 12 LEU A 323
ILE A 390
ILE A 389
VAL A 373
PHE A 393
None
1.16A 2ygpA-4qaxA:
undetectable
2ygpA-4qaxA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB6_0
(FERROCHELATASE)
4qax 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Staphylococcus
aureus)
5 / 12 LEU A 485
LEU A 488
ILE A  69
VAL A 470
VAL A 463
None
1.32A 3aqiB-4qaxA:
undetectable
3aqiB-4qaxA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_B_ADNB402_1
(UNCHARACTERIZED
PROTEIN MJ0883)
4qax 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Staphylococcus
aureus)
5 / 10 PHE A  14
GLY A 440
ASP A 443
ASN A 459
PHE A  33
None
1.24A 3ay0B-4qaxA:
4.8
3ay0B-4qaxA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRE_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)
4qax 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Staphylococcus
aureus)
5 / 9 ALA A 287
LEU A  97
LEU A 132
SER A  85
ILE A  82
None
1.28A 3freX-4qaxA:
undetectable
3freX-4qaxA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_A_ADNA438_1
(ADENOSYLHOMOCYSTEINA
SE)
4qax 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Staphylococcus
aureus)
5 / 12 ASN A 392
LEU A 481
LEU A 478
GLY A  65
HIS A  66
None
1.14A 3g1uA-4qaxA:
undetectable
3g1uA-4qaxA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)
4qax 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Staphylococcus
aureus)
4 / 4 LEU A 486
PRO A 483
LEU A 485
ARG A 324
None
1.28A 3hcoA-4qaxA:
3.5
3hcoA-4qaxA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_B_DSFB319_1
(GLR4197 PROTEIN)
4qax 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Staphylococcus
aureus)
5 / 9 ILE A 390
ILE A 389
VAL A 334
ILE A   9
ILE A  10
None
1.25A 3p4wB-4qaxA:
undetectable
3p4wB-4qaxA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_A_SAMA258_0
(PUTATIVE
METHYLTRANSFERASE)
4qax 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Staphylococcus
aureus)
5 / 12 GLY A  72
GLY A 499
GLN A 493
LEU A 478
ALA A 482
None
1.18A 3sxjA-4qaxA:
3.4
3sxjA-4qaxA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_B_SAMB258_0
(PUTATIVE
METHYLTRANSFERASE)
4qax 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Staphylococcus
aureus)
5 / 12 GLY A  72
GLY A 499
GLN A 493
LEU A 478
ALA A 482
None
1.18A 3sxjB-4qaxA:
3.1
3sxjB-4qaxA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)
4qax 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Staphylococcus
aureus)
5 / 12 HIS A 456
HIS A 401
GLY A 400
ASP A  12
GLY A  13
MN  A 601 (-3.6A)
MN  A 601 (-3.4A)
None
MN  A 602 (-2.1A)
None
1.21A 4lxzA-4qaxA:
3.5
4lxzA-4qaxA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_C_SHHC406_1
(HISTONE DEACETYLASE
2)
4qax 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Staphylococcus
aureus)
5 / 12 HIS A 456
HIS A 401
GLY A 400
ASP A  12
GLY A  13
MN  A 601 (-3.6A)
MN  A 601 (-3.4A)
None
MN  A 602 (-2.1A)
None
1.20A 4lxzC-4qaxA:
2.5
4lxzC-4qaxA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA3_L_ACTL301_0
(C2095 HEAVY CHAIN
C2095 LIGHT CHAIN)
4qax 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Staphylococcus
aureus)
3 / 3 PRO A  55
ASN A  83
HIS A 128
None
1.03A 4ma3H-4qaxA:
undetectable
4ma3L-4qaxA:
undetectable
4ma3H-4qaxA:
15.53
4ma3L-4qaxA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_A_29EA603_1
(TRANSPORTER)
4qax 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Staphylococcus
aureus)
5 / 10 ASP A 230
ALA A 222
TYR A 224
GLY A 184
GLY A 219
None
1.27A 4mmdA-4qaxA:
undetectable
4mmdA-4qaxA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_A_29QA603_1
(TRANSPORTER)
4qax 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Staphylococcus
aureus)
5 / 9 ASP A 230
ALA A 222
TYR A 224
GLY A 184
GLY A 219
None
1.21A 4mmfA-4qaxA:
undetectable
4mmfA-4qaxA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_B_29QB603_1
(TRANSPORTER)
4qax 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Staphylococcus
aureus)
5 / 9 ASP A 230
ALA A 222
TYR A 224
GLY A 184
GLY A 219
None
1.18A 4mmfB-4qaxA:
undetectable
4mmfB-4qaxA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_2
(TUBULIN BETA CHAIN)
4qax 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Staphylococcus
aureus)
5 / 12 LEU A 111
ALA A 136
LEU A  97
ALA A 287
ALA A 250
None
1.21A 4x1iB-4qaxA:
3.1
4x1iB-4qaxA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_B_IMNB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
4qax 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Staphylococcus
aureus)
5 / 11 GLY A 177
ALA A 216
ILE A 164
LEU A 117
ILE A 113
None
1.09A 4xumB-4qaxA:
undetectable
4xumB-4qaxA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_ACTA405_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)
4qax 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Staphylococcus
aureus)
3 / 3 GLN A 444
THR A 457
ASP A 443
None
0.90A 5k9dA-4qaxA:
2.0
5k9dA-4qaxA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)
4qax 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Staphylococcus
aureus)
5 / 12 GLU A 349
ARG A 351
LEU A 489
GLY A 312
SER A 339
None
1.10A 5vooB-4qaxA:
undetectable
5vooB-4qaxA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)
4qax 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Staphylococcus
aureus)
5 / 12 GLU A 349
ARG A 351
LEU A 489
GLY A 312
SER A 339
None
1.14A 5vooC-4qaxA:
2.1
5vooC-4qaxA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_A_9KLA402_0
(EST-Y29)
4qax 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Staphylococcus
aureus)
5 / 12 ILE A 390
LEU A 388
GLY A  72
ALA A 482
LEU A 486
None
1.10A 5zwrA-4qaxA:
undetectable
5zwrA-4qaxA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPL_B_PA1B605_1
(LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA)
4qax 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Staphylococcus
aureus)
3 / 3 ARG A 153
ARG A 197
ARG A 191
2PG  A 603 (-3.8A)
None
2PG  A 603 (-3.3A)
1.01A 6bplA-4qaxA:
undetectable
6bplB-4qaxA:
undetectable
6bplA-4qaxA:
9.59
6bplB-4qaxA:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_0
(NS3 PROTEASE)
4qax 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Staphylococcus
aureus)
5 / 12 PHE A 149
VAL A 144
GLY A 184
PHE A 236
ALA A 216
None
1.20A 6c2mB-4qaxA:
undetectable
6c2mB-4qaxA:
10.55